Search Results - "Andersen, Kasper L"

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia by Messling, Jan-Erik, Agger, Karl, Andersen, Kasper L., Kromer, Kristina, Kuepper, Hanna M., Lund, Anders H., Helin, Kristian

“…Novel therapies for the treatment of acute myeloid leukemia (AML) are urgently needed, because current treatments do not cure most patients with AML. We report…”
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Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk by Hansen, Eline P., Fromm, Bastian, Andersen, Sidsel D., Marcilla, Antonio, Andersen, Kasper L., Borup, Anne, Williams, Andrew R., Jex, Aaron R., Gasser, Robin B., Young, Neil D., Hall, Ross S., Stensballe, Allan, Ovchinnikov, Vladimir, Yan, Yan, Fredholm, Merete, Thamsborg, Stig M., Nejsum, Peter

“…The prevalent porcine helminth, Ascaris suum, compromises pig health and reduces farm productivity worldwide. The closely related human parasite, A…”
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Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents by Wróbel, Tomasz M, Rogova, Oksana, Andersen, Kasper L, Yadav, Rahul, Brixius-Anderko, Simone, Scott, Emily E, Olsen, Lars, Jørgensen, Flemming Steen, Björkling, Fredrik

“…The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic…”
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Knock-Down of a Novel snoRNA in Tetrahymena Reveals a Dual Role in 5.8S rRNA Processing and Generation of a 26S rRNA Fragment by Andersen, Kasper L, Nielsen, Henrik

“…In eukaryotes, 18S, 5.8S, and 28S rRNAs are transcribed as precursor molecules that undergo extensive modification and nucleolytic processing to form the…”
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Accumulation of Stable Full-Length Circular Group I Intron RNAs during Heat-Shock by Andersen, Kasper L, Beckert, Bertrand, Masquida, Benoit, Johansen, Steinar D, Nielsen, Henrik

“…Group I introns in nuclear ribosomal RNA of eukaryotic microorganisms are processed by splicing or circularization. The latter results in formation of…”
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Synthesis and Structure-Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents by Wróbel, Tomasz M, Rogova, Oksana, Sharma, Katyayani, Rojas Velazquez, Maria Natalia, Pandey, Amit V, Jørgensen, Flemming Steen, Arendrup, Frederic S, Andersen, Kasper L, Björkling, Fredrik

“…Twenty new compounds, targeting CYP17A1, were synthesized, based on our previous work on a benzimidazole scaffold, and their biological activity evaluated…”
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Regulation of translation by site-specific ribosomal RNA methylation by Jansson, Martin D., Häfner, Sophia J., Altinel, Kübra, Tehler, Disa, Krogh, Nicolai, Jakobsen, Emil, Andersen, Jens V., Andersen, Kasper L., Schoof, Erwin M., Ménard, Patrice, Nielsen, Henrik, Lund, Anders H.

“…Ribosomes are complex ribozymes that interpret genetic information by translating messenger RNA (mRNA) into proteins. Natural variation in ribosome composition…”
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Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena by Andersen, Kasper L, Collins, Kathleen

“…RNase T2 enzymes are produced by a wide range of organisms and have been implicated to function in diverse cellular processes, including stress-induced…”
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Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions by Häfner, Sophia J., Jansson, Martin D., Altinel, Kübra, Andersen, Kasper L., Abay-Nørgaard, Zehra, Ménard, Patrice, Fontenas, Martin, Sørensen, Daniel M., Gay, David M., Arendrup, Frederic S., Tehler, Disa, Krogh, Nicolai, Nielsen, Henrik, Kraushar, Matthew L., Kirkeby, Agnete, Lund, Anders H.

“…Translational regulation impacts both pluripotency maintenance and cell differentiation. To what degree the ribosome exerts control over this process remains…”
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Experimental identification and analysis of macronuclear non-coding RNAs from the ciliate Tetrahymena thermophila by Andersen, Kasper L., Nielsen, Henrik

“…The ciliate Tetrahymena thermophila is an important eukaryotic model organism that has been used in pioneering studies of general phenomena, such as ribozymes,…”
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Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk by Hansen, Eline P, Fromm, Bastian, Andersen, Sidsel D, Marcilla, Antonio, Andersen, Kasper L, Williams, Andrew R, Jex, Aaron R, Gasser, Robin B, Young, Neil D, Hall, Ross S, Stensballe, Allan, Yan, Yan, Fredholm, Merete, Thamsborg, Stig M, Nejsum, Peter

“…Background: The highly prevalent porcine helminth, Ascaris suum, compromise pig health and reduce farm productivity worldwide. The closely related human…”
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