Search Results - "Andersen, Julie"

Cellular senescence: A link between cancer and age-related degenerative disease? by Campisi, Judith, Andersen, Julie K, Kapahi, Pankaj, Melov, Simon

“…Abstract Cellular senescence is an established cellular stress response that acts primarily to prevent the proliferation of cells that experience potentially…”
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mTORC2: The other mTOR in autophagy regulation by Ballesteros‐Álvarez, Josué, Andersen, Julie K.

“…The mechanistic target of rapamycin (mTOR) has gathered significant attention as a ubiquitously expressed multimeric kinase with key implications for cell…”
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Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease by Chinta, Shankar J., Woods, Georgia, Demaria, Marco, Rane, Anand, Zou, Ying, McQuade, Amanda, Rajagopalan, Subramanian, Limbad, Chandani, Madden, David T., Campisi, Judith, Andersen, Julie K.

“…Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed…”
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Cellular senescence and the aging brain by Chinta, Shankar J., Woods, Georgia, Rane, Anand, Demaria, Marco, Campisi, Judith, Andersen, Julie K.

“…Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation…”
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Making sense of and working with COVID-19 related guidelines and information in Danish general practice-A qualitative study by Andersen, Julie Høgsgaard, Møller, Anne, Due, Tina Drud

“…Attempts to manage the COVID-19 pandemic have involved a massive flow of guidelines and information to health professionals on how to reorganize clinical work…”
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Atrial fibrillation-a complex polygenetic disease by Andersen, Julie H, Andreasen, Laura, Olesen, Morten S

“…Atrial fibrillation (AF) is the most common type of arrhythmia. Epidemiological studies have documented a substantial genetic component. More than 160 genes…”
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Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo by Chinta, Shankar J., Mallajosyula, Jyothi K., Rane, Anand, Andersen, Julie K.

“…▶ α-Syn physically localizes to dopaminergic mitochondria in vivo and impacts on mitochondrial function. ▶ Localization coincides with a selective age-related…”
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"They look into our world" – A qualitative study of intensive support to adolescents with poorly regulated type 1 diabetes and their families by Andersen, Julie Høgsgaard, Hjelle, Jesper Sand, Andersen, Anette

“…This article is based on a qualitative evaluation of a project offering intensive support to Danish adolescents with poorly regulated type I diabetes and their…”
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Oxidative stress in neurodegeneration: cause or consequence? by Andersen, Julie K

“…Oxidative stress has long been linked to the neuronal cell death that is associated with certain neurodegenerative conditions. Whether it is a primary cause or…”
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Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease by Rajagopalan, Subramanian, Rane, Anand, Chinta, Shankar J, Andersen, Julie K

“…We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs) has neuroprotective effects in…”
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Redox imbalance in Parkinson's disease by Chinta, Shankar J., Andersen, Julie K.

“…Parkinson's disease (PD) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain…”
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Oxidative and nitrative protein modifications in Parkinson's disease by Danielson, Steven R., Andersen, Julie K.

“…Parkinson's disease (PD) is a complex neurodegenerative syndrome likely involving contributions from various factors in individuals including genetic…”
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Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence by Walton, Chaska C., Andersen, Julie K.

“…Oxidative stress has long been considered a key component contributing to pathologies associated with brain aging and age-related neurodegenerative diseases…”
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The intestinal immune system and gut barrier function in obesity and ageing by Shemtov, Sarah J, Emani, Rohini, Bielska, Olga, Covarrubias, Anthony J, Verdin, Eric, Andersen, Julie K, Winer, Daniel A

“…Obesity and ageing predispose to numerous, yet overlapping chronic diseases. For example, metabolic abnormalities, including insulin resistance (IR) and type 2…”
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Managing persistent physical symptoms when being social and active is the norm: a qualitative study among young people in Denmark by Andersen, Julie Høgsgaard, Risør, Mette Bech, Frostholm, Lisbeth, Rask, Mette Trøllund, Rosendal, Marianne, Rask, Charlotte Ulrikka

“…Abstract Background An increasing number of young people in Western countries report persistent physical symptoms (PPS). PPS may disturb everyday activities…”
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Screening Method for Identifying Toxicants Capable of Inducing Astrocyte Senescence by Woods, Georgia, Andersen, Julie K

“…Abstract Cellular senescence is a tumor-suppressive mechanism which leads to near irreversible proliferative arrest. However, senescent cells can cause tissue…”
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MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology by Mallajosyula, Jyothi K, Kaur, Deepinder, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Nicholls, David G, Di Monte, Donato A, Macarthur, Heather, Andersen, Julie K

“…Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor…”
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Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis by Walton, Chaska C, Begelman, David, Nguyen, Wynnie, Andersen, Julie K

“…Due to their postmitotic status, the potential for neurons to undergo senescence has historically received little attention. This lack of attention has…”
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Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin by Siddiqui, Almas, Bhaumik, Dipa, Chinta, Shankar J, Rane, Anand, Rajagopalan, Subramanian, Lieu, Christopher A, Lithgow, Gordon J, Andersen, Julie K

“…Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial membrane proteins, initiating…”
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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance by Haller, Samantha, Kapuria, Subir, Riley, Rebeccah R., O’Leary, Monique N., Schreiber, Katherine H., Andersen, Julie K., Melov, Simon, Que, Jianwen, Rando, Thomas A., Rock, Jason, Kennedy, Brian K., Rodgers, Joseph T., Jasper, Heinrich

“…The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is…”
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