Search Results - "Andersen, Jimena"

Generation of Functional Human 3D Cortico-Motor Assembloids by Andersen, Jimena, Revah, Omer, Miura, Yuki, Thom, Nicholas, Amin, Neal D., Kelley, Kevin W., Singh, Mandeep, Chen, Xiaoyu, Thete, Mayuri Vijay, Walczak, Elisabeth M., Vogel, Hannes, Fan, H. Christina, Paşca, Sergiu P.

“…Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components…”
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Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution by Trevino, Alexandro E., Müller, Fabian, Andersen, Jimena, Sundaram, Laksshman, Kathiria, Arwa, Shcherbina, Anna, Farh, Kyle, Chang, Howard Y., Pașca, Anca M., Kundaje, Anshul, Pașca, Sergiu P., Greenleaf, William J.

“…Genetic perturbations of cortical development can lead to neurodevelopmental disease, including autism spectrum disorder (ASD). To identify genomic regions…”
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Long-term maturation of human cortical organoids matches key early postnatal transitions by Gordon, Aaron, Yoon, Se-Jin, Tran, Stephen S., Makinson, Christopher D., Park, Jin Young, Andersen, Jimena, Valencia, Alfredo M., Horvath, Steve, Xiao, Xinshu, Huguenard, John R., Pașca, Sergiu P., Geschwind, Daniel H.

“…Human stem-cell-derived models provide the promise of accelerating our understanding of brain disorders, but not knowing whether they possess the ability to…”
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Assembly of functionally integrated human forebrain spheroids by Birey, Fikri, Andersen, Jimena, Makinson, Christopher D., Islam, Saiful, Wei, Wu, Huber, Nina, Fan, H. Christina, Metzler, Kimberly R. Cordes, Panagiotakos, Georgia, Thom, Nicholas, O’Rourke, Nancy A., Steinmetz, Lars M., Bernstein, Jonathan A., Hallmayer, Joachim, Huguenard, John R., Paşca, Sergiu P.

“…The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons…”
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Maturation and circuit integration of transplanted human cortical organoids by Revah, Omer, Gore, Felicity, Kelley, Kevin W., Andersen, Jimena, Sakai, Noriaki, Chen, Xiaoyu, Li, Min-Yin, Birey, Fikri, Yang, Xiao, Saw, Nay L., Baker, Samuel W., Amin, Neal D., Kulkarni, Shravanti, Mudipalli, Rachana, Cui, Bianxiao, Nishino, Seiji, Grant, Gerald A., Knowles, Juliet K., Shamloo, Mehrdad, Huguenard, John R., Deisseroth, Karl, Pașca, Sergiu P.

“…Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease 1 – 5 . However, organoids lack the…”
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Chromatin accessibility dynamics in a model of human forebrain development by Trevino, Alexandro E, Sinnott-Armstrong, Nasa, Andersen, Jimena, Yoon, Se-Jin, Huber, Nina, Pritchard, Jonathan K, Chang, Howard Y, Greenleaf, William J, Pașca, Sergiu P

“…Forebrain development is characterized by highly synchronized cellular processes, which, if perturbed, can cause disease. To chart the regulatory activity…”
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Return to quiescence of mouse neural stem cells by degradation of a proactivation protein by Urbán, Noelia, van den Berg, Debbie L. C., Forget, Antoine, Andersen, Jimena, Demmers, Jeroen A. A., Hunt, Charles, Ayrault, Olivier, Guillemot, François

“…Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here,…”
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A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells by Andersen, Jimena, Urbán, Noelia, Achimastou, Angeliki, Ito, Ayako, Simic, Milesa, Ullom, Kristy, Martynoga, Ben, Lebel, Mélanie, Göritz, Christian, Frisén, Jonas, Nakafuku, Masato, Guillemot, François

“…The activity of adult stem cells is regulated by signals emanating from the surrounding tissue. Many niche signals have been identified, but it is unclear how…”
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Absent forebrain replaced by embryonic stem cells by Andersen, Jimena, Pașca, Sergiu P.

“…A new technique, in which forebrain-precursor cells are ablated from early-stage mouse embryos and replaced with embryonic stem cells, promises to facilitate…”
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Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence by Martynoga, Ben, Mateo, Juan L, Zhou, Bo, Andersen, Jimena, Achimastou, Angeliki, Urbán, Noelia, van den Berg, Debbie, Georgopoulou, Dimitra, Hadjur, Suzana, Wittbrodt, Joachim, Ettwiller, Laurence, Piper, Michael, Gronostajski, Richard M, Guillemot, François

“…The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling pathways that promote NSC…”
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Complementing the forebrain by Andersen, Jimena, Paşca, Sergiu P

“…[...]unless the genetic modification is engineered to be expressed in only certain cell types, this approach is limited to genes that are not essential for…”
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Generation and assembly of human brain region–specific three-dimensional cultures by Sloan, Steven A., Andersen, Jimena, Pașca, Anca M., Birey, Fikri, Pașca, Sergiu P.

“…The ability to generate region-specific three-dimensional (3D) models to study human brain development offers great promise for understanding the nervous…”
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Single-cell transcriptomic landscape of the developing human spinal cord by Andersen, Jimena, Thom, Nicholas, Shadrach, Jennifer L., Chen, Xiaoyu, Onesto, Massimo Mario, Amin, Neal D., Yoon, Se-Jin, Li, Li, Greenleaf, William J., Müller, Fabian, Pașca, Anca M., Kaltschmidt, Julia A., Pașca, Sergiu P.

“…Understanding spinal cord assembly is essential to elucidate how motor behavior is controlled and how disorders arise. The human spinal cord is exquisitely…”
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Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice by Kamens, Helen M., Andersen, Jimena, Picciotto, Marina R.

“…Rationale Alcohol and nicotine are commonly co-abused. Genetic correlations between responses to these drugs have been reported, providing evidence that common…”
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Transcriptional and post-transcriptional control of Ascl1 in adult hippocampal neurogenesis by Urbán, Noelia, van den Berg, Debbie, Andersen, Jimena, Guillemot, François

“…Adult neurogenesis is regulated by a large number of extrinsic and intrinsic factors. The transcription factor Ascll is expressed by a subset of proliferating…”
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NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche by Heng, Yee Hsieh Evelyn, Zhou, Bo, Harris, Lachlan, Harvey, Tracey, Smith, Aaron, Horne, Elise, Martynoga, Ben, Andersen, Jimena, Achimastou, Angeliki, Cato, Kathleen, Richards, Linda J, Gronostajski, Richard M, Yeo, Giles S, Guillemot, François, Bailey, Timothy L, Piper, Michael

“…Transcription factors of the nuclear factor one (NFI) family play a pivotal role in the development of the nervous system. One member, NFIX, regulates the…”
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Return to quiescence of murine neural stem cells by degradation of a pro-activation protein by Urbán, Noelia, van den Berg, Debbie L.C., Forget, Antoine, Andersen, Jimena, Demmers, Jeroen A., Hunt, Charles, Ayrault, Olivier, Guillemot, François

“…Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here…”
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The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative-Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice by Kamens, Helen M., Andersen, Jimena, Picciotto, Marina R.

“…Background:  The costs associated with alcohol abuse are staggering, therefore much effort has been put into developing new pharmacologic strategies to…”
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Neuron-Astrocyte Interactions: A Human Perspective by Pio, Taylor, Hill, Emily J, Kebede, Nardos, Andersen, Jimena, Sloan, Steven A

“…This chapter explores the intricate interactions between neurons and astrocytes within the nervous system with a particular emphasis on studies conducted in…”
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