Search Results - "Andersen, Gregers R"

Complement activation, regulation, and molecular basis for complement-related diseases by Bajic, Goran, Degn, Søren E, Thiel, Steffen, Andersen, Gregers R

“…The complement system is an essential element of the innate immune response that becomes activated upon recognition of molecular patterns associated with…”
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Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3 by Bajic, Goran, Yatime, Laure, Sim, Robert B., Vorup-Jensen, Thomas, Andersen, Gregers R.

“…Complement receptors (CRs), expressed notably on myeloid and lymphoid cells, play an essential function in the elimination of complement-opsonized pathogens…”
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Structure and activation of C1, the complex initiating the classical pathway of the complement cascade by Mortensen, Simon A., Sander, Bjoern, Jensen, Rasmus K., Pedersen, Jan Skov, Golas, Monika M., Jensenius, Jens C., Hansen, Annette G., Thiel, Steffen, Andersen, Gregers R.

“…The complement system is an important antimicrobial and inflammation-generating component of the innate immune system. The classical pathway of complement is…”
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Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer by Yatime, Laure, Maasch, Christian, Hoehlig, Kai, Klussmann, Sven, Andersen, Gregers R., Vater, Axel

“…L- Oligonucleotide aptamers (Spiegelmers) consist of non-natural L- configured nucleotides and are of particular therapeutic interest due to their high…”
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Toward a structure-based comprehension of the lectin pathway of complement by Kjaer, Troels R., Thiel, Steffen, Andersen, Gregers R.

“…•We present the function of the pattern recognition molecules in the complement system.•Overall models for glycan bound MBL:MASP complexes can be…”
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Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy by Jensen, Rasmus K., Jabs, Frederic, Miehe, Michaela, Mølgaard, Brian, Pfützner, Wolfgang, Möbs, Christian, Spillner, Edzard, Andersen, Gregers R.

“…Background IgE is the central antibody isotype in TH2‐biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE‐targeting…”
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Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement by Mortensen, Sofia, Kidmose, Rune T, Petersen, Steen V, Szilágyi, Ágnes, Prohászka, Zoltan, Andersen, Gregers R

“…Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major…”
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Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction by Jabs, Frederic, Plum, Melanie, Laursen, Nick S., Jensen, Rasmus K., Mølgaard, Brian, Miehe, Michaela, Mandolesi, Marco, Rauber, Michèle M., Pfützner, Wolfgang, Jakob, Thilo, Möbs, Christian, Andersen, Gregers R., Spillner, Edzard

“…Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-IgE…”
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Structural basis for the function of DEAH helicases by He, Yangzi, Andersen, Gregers R, Nielsen, Klaus H

“…DEAH helicases participate in pre‐messenger RNA splicing and ribosome biogenesis. The structure of yeast Prp43p‐ADP reveals the homology of DEAH helicases to…”
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Structure and function of a family of tick-derived complement inhibitors targeting properdin by Braunger, Katharina, Ahn, Jiyoon, Jore, Matthijs M., Johnson, Steven, Tang, Terence T. L., Pedersen, Dennis V., Andersen, Gregers R., Lea, Susan M.

“…Activation of the serum-resident complement system begins a cascade that leads to activation of membrane-resident complement receptors on immune cells, thus…”
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Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family by Nielsen, Nadia Sukusu, Zarantonello, Alessandra, Harwood, Seandean Lykke, Jensen, Kathrine Tejlgård, Kjøge, Katarzyna, Thøgersen, Ida B., Schauser, Leif, Karlsen, Jesper Lykkegaard, Andersen, Gregers R., Enghild, Jan J.

“…A2ML1 is a monomeric protease inhibitor belonging to the A2M superfamily of protease inhibitors and complement factors. Here, we investigate the…”
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Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment by Juul-Madsen, Kristian, Parbo, Peter, Ismail, Rola, Ovesen, Peter L., Schmidt, Vanessa, Madsen, Lasse S., Thyrsted, Jacob, Gierl, Sarah, Breum, Mihaela, Larsen, Agnete, Andersen, Morten N., Romero-Ramos, Marina, Holm, Christian K., Andersen, Gregers R., Zhao, Huaying, Schuck, Peter, Nygaard, Jens V., Sutherland, Duncan S., Eskildsen, Simon F., Willnow, Thomas E., Brooks, David J., Vorup-Jensen, Thomas

“…The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain…”
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The Crystal Structure of Human α2-Macroglobulin Reveals a Unique Molecular Cage by Marrero, Aniebrys, Duquerroy, Stephane, Trapani, Stefano, Goulas, Theodoros, Guevara, Tibisay, Andersen, Gregers R., Navaza, Jorge, Sottrup-Jensen, Lars, Gomis-Rüth, F. Xavier

“…I'm your Venus: The crystal structure of the human methylamine‐induced form of α2‐macroglobulin (α2M) shows its large central cavity can accommodate two…”
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Structural basis for activation of the complement system by component C4 cleavage by Kidmose, Rune T, Laursen, Nick S, Dobó, József, Kjaer, Troels R, Sirotkina, Sofia, Yatime, Laure, Sottrup-Jensen, Lars, Thiel, Steffen, Gál, Péter, Andersen, Gregers R

“…An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical…”
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α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes by Stevenson, Liz, Laursen, Erik, Cowan, Graeme J, Bandoh, Betty, Barfod, Lea, Cavanagh, David R, Andersen, Gregers R, Hviid, Lars

“…Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P…”
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Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System by Pedersen, Dennis V, Gadeberg, Trine A F, Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K, Mazarakis, Sofia M M, Revel, Margot, El Sissy, Carine, Petersen, Steen V, Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S, Fremeaux-Bacchi, Véronique, Andersen, Gregers R

“…Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative…”
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Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes by Degn, Søren E., Kjaer, Troels R., Kidmose, Rune T., Jensen, Lisbeth, Hansen, Annette G., Tekin, Mustafa, Jensenius, Jens C., Andersen, Gregers R., Thiel, Steffen

“…Significance A salient feature of the immune system is its ability to discriminate self from nonself. We define the molecular mechanism governing activation of…”
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Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System by Laursen, Nick S, Pedersen, Dennis V, Gytz, Heidi, Zarantonello, Alessandra, Bernth Jensen, Jens Magnus, Hansen, Annette G, Thiel, Steffen, Andersen, Gregers R

“…The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation…”
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Properdin oligomers adopt rigid extended conformations supporting function by Pedersen, Dennis V, Pedersen, Martin Nors, Mazarakis, Sofia Mm, Wang, Yong, Lindorff-Larsen, Kresten, Arleth, Lise, Andersen, Gregers R

“…Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the…”
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A Noncoding Expansion in EIF4A3 Causes Richieri-Costa-Pereira Syndrome, a Craniofacial Disorder Associated with Limb Defects by Favaro, Francine P., Alvizi, Lucas, Zechi-Ceide, Roseli M., Bertola, Debora, Felix, Temis M., de Souza, Josiane, Raskin, Salmo, Twigg, Stephen R.F., Weiner, Andrea M.J., Armas, Pablo, Margarit, Ezequiel, Calcaterra, Nora B., Andersen, Gregers R., McGowan, Simon J., Wilkie, Andrew O.M., Richieri-Costa, Antonio, de Almeida, Maria L.G., Passos-Bueno, Maria Rita

“…Richieri-Costa-Pereira syndrome is an autosomal-recessive acrofacial dysostosis characterized by mandibular median cleft associated with other craniofacial…”
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