Search Results - "Andersen, Asser S"

Structural Basis for the Lower Affinity of the Insulin-like Growth Factors for the Insulin Receptor by Gauguin, Lisbeth, Klaproth, Birgit, Sajid, Waseem, Andersen, Asser S., McNeil, Kerrie A., Forbes, Briony E., De Meyts, Pierre

“…Insulin and the insulin-like growth factors (IGFs) bind with high affinity to their cognate receptor and with lower affinity to the noncognate receptor. The…”
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Chemical Synthesis of Phosphorylated Insulin-like Growth Factor Binding Protein 2 by Premdjee, Bhavesh, Andersen, Asser S, Larance, Mark, Conde-Frieboes, Kilian W, Payne, Richard J

“…Chemical protein synthesis is a powerful avenue for accessing homogeneously modified proteins. While a significant number of small modified proteins bearing…”
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Structural Basis of the Aberrant Receptor Binding Properties of Hagfish and Lamprey Insulins by Sajid, Waseem, Holst, Patricia A, Kiselyov, Vladislav V, Andersen, Asser S, Conlon, J. Michael, Kristensen, Claus, Kjeldsen, Thomas, Whittaker, Jonathan, Chan, Shu J, De Meyts, Pierre

“…The insulin from the Atlantic hagfish (Myxine glutinosa) has been one of the most studied insulins from both a structural and a biological viewpoint; however,…”
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Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks by Schäffer, Lauge, Brissette, Renee E., Spetzler, Jane C., Pillutla, Renuka C., Østergaard, Søren, Lennick, Michael, Brandt, Jakob, Fletcher, Paul W., Danielsen, Gillian M., Hsiao, Ku-Chuan, Andersen, Asser S., Dedova, Olga, Ribel, Ulla, Hoeg-Jensen, Thomas, Hansen, Per Hertz, Blume, Arthur J., Markussen, Jan, Goldstein, Neil I.

“…Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the…”
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Peptides Identify the Critical Hotspots Involved in the Biological Activation of the Insulin Receptor by Pillutla, Renuka C., Hsiao, Ku-chuan, Beasley, James R., Brandt, Jakob, Østergaard, Søren, Hansen, Per Hertz, Spetzler, Jane C., Danielsen, Gillian M., Andersen, Asser S., Brissette, Renee E., Lennick, Michael, Fletcher, Paul W., Blume, Arthur J., Schäffer, Lauge, Goldstein, Neil I.

“…We used phage display to generate surrogate peptides that define the hotspots involved in protein-protein interaction between insulin and the insulin receptor…”
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Backbone cyclic insulin by Andersen, Asser S., Palmqvist, Eva, Bang, Susanne, Shaw, Allan C., Hubalek, Frantisek, Ribel, Ulla, Hoeg-Jensen, Thomas

“…Backbone cyclic insulin was designed and prepared by reverse proteolysis in partial organic solvent of a single‐chain precursor expressed in yeast. The…”
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Alanine Scanning Mutagenesis of Insulin by Kristensen, Claus, Kjeldsen, Thomas, Wiberg, Finn C., Schäffer, Lauge, Hach, Morten, Havelund, Svend, Bass, Joseph, Steiner, Donald F., Andersen, Asser S.

“…Alanine scanning mutagenesis has been used to identify specific side chains of insulin which strongly influence binding to the insulin receptor. A total of 21…”
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Changing the insulin receptor to possess insulin-like growth factor I ligand specificity by Andersen, Asser S, Kjeldsen, Thomas, Wiberg, Finn C, Christensen, Per Michael, Skou Rasmussen, Jesper, Norris, Kjeld, Bach Moeller, Karin, Moeller, Niels Peter H

“…To examine the role of the N-terminal part of the insulin-like growth factor I (IGF-I) receptor and insulin receptor in determining ligand specificity, we…”
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Properties of Small Molecules Affecting Insulin Receptor Function by Schlein, Morten, Ludvigsen, Svend, Olsen, Helle B, Andersen, Asser S, Danielsen, Gillian M, Kaarsholm, Niels C

“…Small molecules with insulin mimetic effects and oral availability are of interest for potential substitution of insulin injections in the treatment of…”
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Specificity of Insulin and Insulin-like Growth Factor I Receptors Investigated using Chimeric Mini-Receptors by Kristensen, Claus, Wiberg, Finn C., Andersen, Asser S.

“…We have investigated the role of the C-terminal of the α-subunit in the insulin receptor family by characterizing chimeric mini-receptor constructs comprising…”
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Expression and Characterization of a 70-kDa Fragment of the Insulin Receptor That Binds Insulin by Kristensen, Claus, Wiberg, Finn C., Schäffer, Lauge, Andersen, Asser S.

“…In order to characterize regions of the insulin receptor that are essential for ligand binding and possibly identify a smaller insulin-binding fragment of the…”
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Primary structure of fox (Vulpes vulpes) proinsulin based on sequence studies of pancreatic peptides and cDNA by Fiertek, Dariusz, Gromowska, Małgorzata, Andersen, Asser S., Hansen, Per H., Majewski, Tadeusz, Izdebski, Jan

“…Insulin and C‐peptide were extracted and purified from fox (Vulpes vulpes) pancreas using gel filtration, ion‐exchange chromatography and HPLC. Chromatographic…”
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Reception and transmission by Andersen, Asser S

“…The activity of cell-surface receptors is in many cases controlled by their association state in the membrane, and the association state is in turn regulated…”
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Structural Basis of the Aberrant Receptor Binding Properties of Hagfish and Lamprey Insulins aNB by Sajid, Waseem, Holst, Patricia A, Kiselyov, Vladislav V, Andersen, Asser S, Conlon, JMichael, Kristensen, Claus, Kjeldsen, Thomas, Whittaker, Jonathan, Chan, Shu J, De Meyts, Pierre

“…The insulin from the Atlantic hagfish (Myxine glutinosa) has been one of the most studied insulins from both a structural and a biological viewpoint; however,…”
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Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit by Kristensen, C, Wiberg, F C, Andersen, A S

“…We have investigated the role of the C-terminal of the alpha-subunit in the insulin receptor family by characterizing chimeric mini-receptor constructs…”
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Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast by Thim, Lars, Nielsen, Per F., Judge, Martin E., Andersen, Asser S., Diers, Ivan, Egel-Mitani, Michi, Hastrup, Sven

“…Cocaine and amphetamine regulated transcript (CART) is a newly discovered hypothalamic peptide with a potent appetite suppressing activity following…”
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P-17 STRUCTURAL BASIS FOR THE LOWER AFFINITY OF THE INSULIN-LIKE GROWTH FACTORS FOR THE INSULIN RECEPTOR by Gauguin, Lisbeth, Forbes, Briony E, Andersen, Asser S, De Meyts, Pierre

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Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor by Kristensen, C, Wiberg, F C, Schäffer, L, Andersen, A S

“…In order to characterize regions of the insulin receptor that are essential for ligand binding and possibly identify a smaller insulin-binding fragment of the…”
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A removable spacer peptide in an α-factor-leader/insulin precursor fusion protein improves processing and concomitant yield of the insulin precursor in Saccharomyces cerevisiae by Kjeldsen, Thomas, Brandt, Jakob, Andersen, Asser S., Egel-Mitani, Michi, Hach, Morten, Pettersson, Annette Frost, Vad, Knud

“…An α-factor leader/insulin precursor fusion protein was produced in Saccharomyces cerevisiae and metabolically labeled in order to analyse the efficiency of…”
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The Ligand Specificities of the Insulin Receptor and the Insulin-Like Growth Factor I Receptor Reside in Different Regions of a Common Binding Site by Kjeldsen, Thomas, Andersen, Asser S., Wiberg, Finn C., Rasmussen, Jesper Skou, Schaffer, Lauge, Balschmidt, Per, Moller, Karin Bach, Niels Peter H. Moller

“…To identify the region(s) of the insulin receptor and the insulin-like growth factor I (IGF-I) receptor responsible for ligand specificity (high-affinity…”
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