Search Results - "Andersch, Lena"

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing by Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C, Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H, Künkele, Annette

“…Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical…”
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A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization by Grunewald, Laura, Lam, Tobias, Andersch, Lena, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Gauert, Anton, Heeren-Hagemann, Anja I., Astrahantseff, Kathy, Klironomos, Filippos, Thomas, Alexander, Deubzer, Hedwig E., Henssen, Anton G., Eggert, Angelika, Schulte, Johannes H., Anders, Kathleen, Kloke, Lutz, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models and clinical trials is often less effective than predicted by CAR…”
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Combination of GD2-directed bispecific trifunctional antibody therapy with Pd-1 immune checkpoint blockade induces anti-neuroblastoma immunity in a syngeneic mouse model by Ivasko, Sara Marie, Anders, Kathleen, Grunewald, Laura, Launspach, Michael, Klaus, Anika, Schwiebert, Silke, Ruf, Peter, Lindhofer, Horst, Lode, Holger N, Andersch, Lena, Schulte, Johannes H, Eggert, Angelika, Hundsdoerfer, Patrick, Künkele, Annette, Zirngibl, Felix

“…Despite advances in treating high-risk neuroblastoma, 50-60% of patients still suffer relapse, necessitating new treatment options. Bispecific trifunctional…”
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GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma by Zirngibl, Felix, Ivasko, Sara M, Grunewald, Laura, Klaus, Anika, Schwiebert, Silke, Ruf, Peter, Lindhofer, Horst, Astrahantseff, Kathy, Andersch, Lena, Schulte, Johannes H, Lode, Holger N, Eggert, Angelika, Anders, Kathleen, Hundsdoerfer, Patrick, Künkele, Annette

“…BackgroundNeuroblastoma is the most common extracranial solid tumor of childhood. Patients with high-risk disease undergo extremely aggressive therapy and…”
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Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells by Kath, Jonas, Franke, Clemens, Drosdek, Vanessa, Du, Weijie, Glaser, Viktor, Fuster-Garcia, Carla, Stein, Maik, Zittel, Tatiana, Schulenberg, Sarah, Porter, Caroline E., Andersch, Lena, Künkele, Annette, Alcaniz, Joshua, Hoffmann, Jens, Abken, Hinrich, Abou-el-Enein, Mohamed, Pruß, Axel, Suzuki, Masataka, Cathomen, Toni, Stripecke, Renata, Volk, Hans-Dieter, Reinke, Petra, Schmueck-Henneresse, Michael, Wagner, Dimitrios L.

“…•Integration of ζ-deficient CARs into the CD3ζ gene allows generation of functional TCR-ablated CAR-T cells for allogeneic off-the-shelf use.•CD3ζ-editing…”
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Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis by Sulejmani, Ornela, Grunewald, Laura, Andersch, Lena, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Astrahantseff, Kathy, Eggert, Angelika, Henssen, Anton G., Schulte, Johannes H., Anders, Kathleen, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising treatment strategy, however, therapeutic success against solid tumors such as…”
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