Search Results - "Andemichael, Yemane"

Nucleophilic Aromatic Substitutions of 2‑Halo-5-(sulfamoyl)benzoic Acids and N,O-Bis-alkylation via Phase Transfer Catalysis: Synthesis of RoRγ Inverse Agonist GSK2981278A by Barcan, Gregg A, Conde, Jose J, Mokhallalati, Mohamed K, Nilson, Mark G, Xie, Shiping, Allen, C. Liana, Andemichael, Yemane W, Calandra, Nicholas A, Leitch, David C, Li, Ling, Morris, Michael J

“…GSK2981278A (1) is a RORγ inverse agonist used as a potential topical nonsteroidal therapy for psoriasis. New synthesis of 1 was developed based on a SNAr…”
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A Scalable Synthesis of 2S-Hydroxymutilin via a Modified Rubottom Oxidation by Wang, Huan, Andemichael, Yemane W, Vogt, Frederick G

“…A scalable synthesis of 2S-hydroxymutilin from pleuromutilin was developed. The synthesis is highlighted by the Rubottom oxidation of a silyl enol ether,…”
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Improved Synthesis of Enantiopure Sulfinimines (Thiooxime S-Oxides) from p-Toluenesulfinamide and Aldehydes and Ketones by Davis, Franklin A, Zhang, Yulian, Andemichael, Yemane, Fang, Tianan, Fanelli, Dean L, Zhang, Huiming

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Asymmetric Synthesis of 4-Hydroxy-3-phenyltetrahydroisoquinoline Derivatives Using Enantiopure Sulfinimines (N-Sulfinyl Imines) by Davis, Franklin A, Andemichael, Yemane W

“…Addition of lateral lithiated amides and phthalide anions to enantiopure sulfinimines (N-sulfinyl imines) represents a new approach for the asymmetric…”
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Sulfinimine-Mediated Asymmetric Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines:  A Stereoselective Synthesis of cis- and trans-6,8-Dimethoxy-1,3-dimethyl- 1,2,3,4-tetrahydroisoquinoline by Davis, Franklin A, Mohanty, Pradyumna K, Burns, David M, Andemichael, Yemane W

“…The highly diastereoselective addition of lateral lithiated o-tolunitriles to sulfinimines followed by treatment of the resulting sulfinamide with MeLi,…”
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Stereoselective synthesis of both (E)- and (Z)-1,2,4-heptatrien-6-ynes. Formation of an .alpha.,3-dehydrotoluene biradical, trapping by an intramolecular carbon-carbon double bond, and decay of the resulting new biradical via an intramolecular route by Andemichael, Yemane W, Gu, Yu Gui, Wang, Kung K

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A facile synthesis of 5-methylene-1,3-cyclohexadienes (o-isotoluenes) and 1,2,4,6-heptatetraenes by Andemichael, Yemane W, Wang, Kung K

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A Scalable Synthesis of 2 S -Hydroxymutilin via a Modified Rubottom Oxidation by Wang, Huan, Andemichael, Yemane W., Vogt, Frederick G.

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Thermally-induced one-step construction of the tetracyclic steroidal skeleton from acyclic enyne-allenes by Andemichael, Yemane W., Huang, Ying, Wang, Kung K.

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A spectroscopic and computational study of stereochemistry in 2-hydroxymutilin by Vogt, Frederick G., Spoors, Grant P., Su, Qiaogong, Andemichael, Yemane W., Wang, Huan, Potter, Thomas C., Minick, Douglas J.

“…A computational and spectroscopic study of two epimers of 2-hydroxymutilin was conducted to obtain assignments for the configuration of the carbon at the…”
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Process Development for A Novel Pleuromutilin-Derived Antibiotic by Andemichael, Yemane, Chen, Jun, Clawson, Jacalyn S, Dai, Wenning, Diederich, Ann, Downing, Susan V, Freyer, Alan J, Liu, Peng, Oh, Lynette M, Patience, Daniel B, Sharpe, Sonja, Sisko, Joseph, Tsui, Julie, Vogt, Frederick G, Wang, Jun, Wernersbach, Lori, Webb, Edward C, Wertman, James, Zhou, Leon

“…A scalable synthesis of a novel pleuromutilin-based antibiotic is reported. The synthesis features the scale-up of an interesting skeletal rearrangement of the…”
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Sulfinimine mediated asymmetric synthesis of 3-substituted-1(2 H)-isoquinolones: (3 R,4 S)-(−)-4-hydroxy-3-phenyltetrahydroisoquinoline by Davis, Franklin A., Andemichael, Yemane W.

“…A general approach to enantiomerically pure 3-substituted-1(2 H)-isoquinolones is illustrated by the addition of lateral lithiated amide 7 to sulfinimine 5…”
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