Search Results - "Ancsin, JB"

Characterization of High Affinity Binding between Laminin and the Acute-phase Protein, Serum Amyloid A by Ancsin, J B, Kisilevsky, R

“…Serum amyloid A isoforms, apoSAA1 and apoSAA2, are acute-phase proteins of unknown function and can be precursors of amyloid AA peptides (AA) found in animal…”
Get full text

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein by Noborn, Fredrik, O'Callaghan, Paul, Hermansson, Erik, Zhang, Xiao, Ancsin, John B, Damas, Ana M, Dacklin, Ingrid, Presto, Jenny, Johansson, Jan, Saraiva, Maria J, Lundgren, Erik, Kisilevsky, Robert, Westermark, Per, Li, Jin-Ping

“…Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result…”
Get full text

A binding site for highly sulfated heparan sulfate is identified in the N terminus of the circumsporozoite protein: significance for malarial sporozoite attachment to hepatocytes by Ancsin, John B, Kisilevsky, Robert

“…Circumsporozoite protein (CSP) coats the malarial sporozoite and functions to target the liver for infection, which is the first step to developing malaria. An…”
Get full text

Amyloidogenesis: historical and modern observations point to heparan sulfate proteoglycans as a major culprit by Ancsin, John B.

“…Amyloids are complex tissue deposits and each type is identified by one of 22 different proteins or peptides which become re-folded into non-native…”
Get full text

The heparin/heparan sulfate-binding site on apo-serum amyloid A. Implications for the therapeutic intervention of amyloidosis by Ancsin, J B, Kisilevsky, R

“…Serum amyloid A isoforms, apoSAA1 and apoSAA2, are apolipoproteins of unknown function that become major components of high density lipoprotein (HDL) during…”
Get full text

Amyloidogenesis recapitulated in cell culture: a peptide inhibitor provides direct evidence for the role of heparan sulfate and suggests a new treatment strategy by Elimova, Elena, Kisilevsky, Robert, Szarek, Walter A., Ancsin, John B.

“…ABSTRACT To date 22 different polypeptides, including Aβ in Alzheimer’s disease and PrPSc in prion disorders, are known to re‐fold and assemble into highly…”
Get full text

Inhibition of amyloid A amyloidogenesis in vivo and in tissue culture by 4-deoxy analogues of peracetylated 2-acetamido-2-deoxy-α- and β-D-glucose: Implications for the treatment of various amyloidoses by KISILEVSKY, Robert, SZAREK, Walter A, ANCSIN, John B, ELIMOVA, Elena, MARONE, Sandra, BHAT, Shridhar, BERKIN, Ali

“…Two novel sugars, 2-acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-alpha- and beta-D-xylo-hexopyranoses, have been synthesized and their effects on heparan sulfate…”
Get full text

Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE[superscript -/-] mice by Tam, Shui Pang, Ancsin, John B, Tan, Ruth, Kisilevsky, Robert

“…Macrophages (M{phi}) at sites of acute tissue injury accumulate and export cholesterol quickly. This metabolic activity is likely dependent on the…”
Get full text

Rapid recycling of cholesterol: The joint biologic role of C-reactive protein and serum amyloid A by Manley, P.N., Ancsin, J.B., Kisilevsky, R.

“…Proteins that are highly conserved throughout evolution are presumed to have critical roles in the survival of the species. The two major acute phase proteins,…”
Get full text

Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis by Röcken, C, Fändrich, M, Stix, B, Tannert, A, Hortschansky, P, Reinheckel, T, Saftig, P, Kähne, T, Menard, R, Ancsin, JB, Bühling, F

“…In cerebral amyloidoses, such as Alzheimer's disease, proteolytic processing of the precursor protein is a fundamental mechanism of the disease, since it…”
Get full text

Laminin Interactions Important for Basement Membrane Assembly Are Promoted by Zinc and Implicate Laminin Zinc Finger-like Sequences by Ancsin, J B, Kisilevsky, R

“…Laminin is an abundant basement membrane (BM) glycoprotein which regulates specific cellular functions and participates in the assembly and maintenance of the…”
Get full text

Laminin interactions with the apoproteins of acute-phase HDL: preliminary mapping of the laminin binding site on serum amyloid A by Ancsin, John B., Kisilevsky, Robert

“…During AA amyloidosis, the major basement membrane components, collagen type-IV (C-IV), entactin, laminin and perlecan codeposit both spatially and temporally…”
Get full text

Purification and characterization of two storage proteins from Locusta migratoria showing distinct developmental and hormonal regulation by Ancsin, John B., Wyatt, Gerard R.

“…Two major hemolymph proteins, belonging to the insect hexameric storage protein family, have been purified from Locusta migratoria. Larval storage protein 1…”
Get full text

The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol by Ely, Sarah, Bonatesta, Rosa, Ancsin, John B., Kindy, Mark, Kisilevsky, Robert

“…The intracellular balance between un-esterified and esterrfied cholesterol is regulated by two enzyme activities, cholesterol ester hydrolases, which drive the…”
Get full text