Search Results - "Ancliffe, Mathew"
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Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue
Published in Diabetologia (2020)“…Aims/hypothesis Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to…”
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Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets
Published in Frontiers in immunology (03-03-2022)“…Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment…”
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A novel technique of serial biopsy in mouse brain tumour models
Published in PloS one (10-04-2017)“…Biopsy is often used to investigate brain tumour-specific abnormalities so that treatments can be appropriately tailored. Dacomitinib (PF-00299804) is a…”
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MODL-18. Enhancing anti-CD47 mAb efficacy with radiotherapy for Group 3 paediatric medulloblastoma in preclinical models
Published in Neuro-oncology (Charlottesville, Va.) (03-06-2022)“…Medulloblastoma is the most common paediatric brain cancer. Standard treatment approaches, including craniospinal irradiation (CSI), can result in severe…”
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Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma
Published in Science translational medicine (20-01-2021)“…Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by…”
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RONC-14. REPLICATING CLINICAL RADIATION THERAPY PROTOCOLS IN PRECLINICAL BRAIN TUMOUR MODELS
Published in Neuro-oncology (Charlottesville, Va.) (22-06-2018)“…Abstract Surgical resection and radiotherapy, often followed by chemotherapy, have been the mainstay of paediatric brain cancer treatment for decades. For…”
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Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma
Published in Neuro-oncology (Charlottesville, Va.) (05-01-2023)“…Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular…”
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Assessment of Cannabidiol and Δ9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma
Published in Cancers (18-01-2021)“…Children with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however,…”
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