Anti-inflammatory and analgesic properties of the stem bark extracts of Erythrophleum suaveolens (Caesalpiniaceae), Guillemin & Perrottet

The MeOH stem bark extract of Erythrophleum suaveolens dissolved in water and shaken up with ethylacetate (EtOAc) and fractionated on a polyamide column with methanol as eluent produced five principal fractions. These fractions were designated as fraction A (74.8 mg yield and rich in alkaloids), fra...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 77; no. 2; pp. 137 - 141
Main Authors:	Dongmo, A.B, Kamanyi, A, Anchang, M.S, Chungag-Anye Nkeh, B, Njamen, D, Nguelefack, T.B, Nole, T, Wagner, H
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-10-2001 Elsevier
Subjects:	5-Lipoxygenase Analgesia Analgesic Animals Anti-inflammatory Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Carrageenan Carrageenan - antagonists & inhibitors Female General pharmacology Lipoxygenase Inhibitors Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - analysis Plant Extracts - isolation & purification Plant Extracts - therapeutic use procyanidins Rats Rats, Wistar Analgesic Carrageenan Anti-inflammatory procyanidins 5-Lipoxygenase Rat Tropical zone Bark Extract Stem Medicinal plant Alkaloid Folk medicine Dicotyledones Angiospermae Phytotherapy Enzyme Pharmacognosy Rodentia Antiinflammatory agent Biological activity Vertebrata Mammalia Leguminosae Animal Plant origin Spermatophyta Oxidoreductases Lipoxygenase
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Summary:	The MeOH stem bark extract of Erythrophleum suaveolens dissolved in water and shaken up with ethylacetate (EtOAc) and fractionated on a polyamide column with methanol as eluent produced five principal fractions. These fractions were designated as fraction A (74.8 mg yield and rich in alkaloids), fraction B (36.6 mg), fraction C (7.8 mg yield, monomeric procyanidin), fraction D (26.6 mg yield, rich in monomeric and oligomeric procyanidin), and fraction E (18.1 mg yield, rich in polymeric procyanidin). The original MeOH extract administered (100 mg/kg po) produced about 47% inhibition of carrageenin-induced paw oedema 1 h after administration. Fraction D, obtained from the ethylacetate extract and rich in procyanidins produced over 33% inhibition of carrageenan-induced paw oedema while a dose of 19.2 μg/ml produced 100% inhibitory effect on 5-lipoxygenase. A dose of 100 mg/kg of the MeOH extract also produced over 30% reduction of the sensitivity to pain while 50 mg/kg of fraction D rich in procyanidins produced over 45% analgesic effects. These results were judged significant compared to those obtained with indomethacin and acetylsalicylic acid. These findings suggest that extracts of the bark of Erythrophleum suaveolens possess potent anti-inflammatory and analgesic property and that the procyanidins lead to the observable pharmacological effects.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(01)00296-3