Search Results - "Anat, A"
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Prophage Excision Activates Listeria Competence Genes that Promote Phagosomal Escape and Virulence
Published in Cell (17-08-2012)“…The DNA uptake competence (Com) system of the intracellular bacterial pathogen Listeria monocytogenes is considered nonfunctional. There are no known…”
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A new perspective on lysogeny: prophages as active regulatory switches of bacteria
Published in Nature reviews. Microbiology (01-10-2015)“…In this Opinion article, Herskovits and colleagues introduce an emerging class of bacteria–phage symbiotic interaction — which they term 'active lysogeny' — in…”
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Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes
Published in PLoS genetics (19-02-2016)“…Bacteria sense and respond to many environmental cues, rewiring their regulatory network to facilitate adaptation to new conditions/niches. Global…”
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Integrative genomic analysis identifies isoleucine and CodY as regulators of Listeria monocytogenes virulence
Published in PLoS genetics (01-09-2012)“…Intracellular bacterial pathogens are metabolically adapted to grow within mammalian cells. While these adaptations are fundamental to the ability to cause…”
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Temperate bacteriophages as regulators of host behavior
Published in Current opinion in microbiology (01-08-2017)“…Highlights • Lysogeny provides a unique state that promotes bacterial–phage mutualistic interactions. • Temperate phages regulate bacterial gene expression and…”
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Active Lysogeny in Listeria Monocytogenes Is a Bacteria-Phage Adaptive Response in the Mammalian Environment
Published in Cell reports (Cambridge) (28-07-2020)“…Some Listeria monocytogenes (Lm) strains harbor a prophage within the comK gene, which renders it inactive. During Lm infection of macrophage cells, the…”
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Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector
Published in PLoS genetics (12-03-2018)“…Listeria monocytogenes (Lm) is a saprophyte and intracellular pathogen. Transition to the pathogenic state relies on sensing of host-derived metabolites, yet…”
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An Effective Counterselection System for Listeria monocytogenes and Its Use To Characterize the Monocin Genomic Region of Strain 10403S
Published in Applied and environmental microbiology (15-03-2017)“…Construction of mutants by allelic exchange has been laborious and time-consuming due to lack of proficient selection markers for the final recombination…”
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Coordination of cohabiting phage elements supports bacteria–phage cooperation
Published in Nature communications (21-11-2019)“…Bacterial pathogens often carry multiple prophages and other phage-derived elements within their genome, some of which can produce viral particles in response…”
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Organizational commitment and quality of life at work among public health nurses in Israel
Published in Public health Nursing (01-07-2019)“…Objective To test the relationship between job satisfaction, professional self‐image, work environment, organizational commitment (OC), and quality of life at…”
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Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression
Published in mBio (28-06-2022)“…Listeria monocytogenes is a saprophyte and a human intracellular pathogen. Upon invasion into mammalian cells, it senses multiple metabolic and environmental…”
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The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA
Published in Molecular microbiology (01-02-2015)“…Summary Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of…”
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L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes
Published in PLoS pathogens (01-01-2017)“…The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host…”
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A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response
Published in Cell reports (Cambridge) (19-04-2022)“…Listeria monocytogenes strain 10403S harbors two phage elements in its chromosome; one produces infective virions and the other tailocins. It was previously…”
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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
Published in Nature Immunology (01-02-2006)“…Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular…”
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Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system
Published in PLoS pathogens (01-03-2007)“…Macrophages are permissive hosts to intracellular pathogens, but upon activation become microbiocidal effectors of innate and cell-mediated immunity. How the…”
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Metabolic Genetic Screens Reveal Multidimensional Regulation of Virulence Gene Expression in Listeria monocytogenes and an Aminopeptidase That Is Critical for PrfA Protein Activation
Published in Infection and immunity (01-06-2017)“…is an environmental saprophyte and intracellular bacterial pathogen. Upon invading mammalian cells, the bacterium senses abrupt changes in its metabolic…”
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Listeria monocytogenes Multidrug Resistance Transporters and Cyclic Di-AMP, Which Contribute to Type I Interferon Induction, Play a Role in Cell Wall Stress
Published in Journal of Bacteriology (01-12-2013)“…The intracellular bacterial pathogen Listeria monocytogenes activates a robust type I interferon response upon infection. This response is partially dependent…”
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Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes
Published in Microbiology spectrum (01-07-2019)“…Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication…”
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The human P-glycoprotein transporter enhances the type I interferon response to Listeria monocytogenes infection
Published in Infection and immunity (01-06-2015)“…Human multidrug efflux transporters are known for their ability to extrude antibiotics and toxic compounds out of cells, yet accumulating data indicate they…”
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