Search Results - "Anastasios Georgiadis"

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina by Gonzalez-Cordero, Anai, West, Emma L, Pearson, Rachael A, Duran, Yanai, Carvalho, Livia S, Chu, Colin J, Naeem, Arifa, Blackford, Samuel J I, Georgiadis, Anastasios, Lakowski, Jorn, Hubank, Mike, Smith, Alexander J, Bainbridge, James W B, Sowden, Jane C, Ali, Robin R

“…Optic cup-like structures generated from mouse ES cells produce photoreceptor precursors that integrate and mature in vivo in three models of retinal…”
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AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR -Associated X-Linked Retinitis Pigmentosa by Sladen, Paul E, Naeem, Arifa, Adefila-Ideozu, Toyin, Vermeule, Tijmen, Busson, Sophie L, Michaelides, Michel, Naylor, Stuart, Forbes, Alexandria, Lane, Amelia, Georgiadis, Anastasios

“…Variants within the Retinitis Pigmentosa GTPase regulator ( ) gene are the predominant cause of X-Linked Retinitis Pigmentosa (XLRP), a common and severe form…”
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Use of bioreactors for culturing human retinal organoids improves photoreceptor yields by Ovando-Roche, Patrick, West, Emma L, Branch, Matthew J, Sampson, Robert D, Fernando, Milan, Munro, Peter, Georgiadis, Anastasios, Rizzi, Matteo, Kloc, Magdalena, Naeem, Arifa, Ribeiro, Joana, Smith, Alexander J, Gonzalez-Cordero, Anai, Ali, Robin R

“…The use of human pluripotent stem cell-derived retinal cells for cell therapy strategies and disease modelling relies on the ability to obtain healthy and…”
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Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration by Kruczek, Kamil, Gonzalez-Cordero, Anai, Goh, Debbie, Naeem, Arifa, Jonikas, Mindaugas, Blackford, Samuel J.I., Kloc, Magdalena, Duran, Yanai, Georgiadis, Anastasios, Sampson, Robert D., Maswood, Ryea N., Smith, Alexander J., Decembrini, Sarah, Arsenijevic, Yvan, Sowden, Jane C., Pearson, Rachael A., West, Emma L., Ali, Robin R.

“…The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a…”
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Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer-A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts by Kampik, Daniel, Basche, Mark, Georgiadis, Anastasios, Luhmann, Ulrich F O, Larkin, D Frank, Smith, Alexander J, Ali, Robin R

“…Endothelial cell density (ECD) is the principal factor determining the success of corneal transplants. Here we explored a strategy to increase corneal ECD in…”
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Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration by Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A, South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M, Kanuga, Naheed, Mackenzie, Francesca E, Dubis, Adam M, Georgiadis, Anastasios, Graca, Anna B, Pearson, Rachael A, Ali, Robin R, Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y, Reeves, Philip J, Cheetham, Michael E

“…Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic 'gain of function', such as the dominant P23H…”
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Effective AAV-mediated gene replacement therapy in retinal organoids modeling AIPL1-associated LCA4 by Sai, Hali, Ollington, Bethany, Rezek, Farah O., Chai, Niuzheng, Lane, Amelia, Georgiadis, Anastasios, Bainbridge, James, Michaelides, Michel, Sacristan-Reviriego, Almudena, Perdigão, Pedro R.L., Leung, Amy, van der Spuy, Jacqueline

“…Biallelic variations in the aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) gene cause Leber congenital amaurosis subtype 4 (LCA4), an autosomal…”
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Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA by Sourisseau, Tony, Georgiadis, Anastasios, Tsapara, Anna, Ali, Robin R., Pestell, Richard, Matter, Karl, Balda, Maria S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice by Georgiadis, Anastasios, Tschernutter, Marion, Bainbridge, James W B, Balaggan, Kamaljit S, Mowat, Freya, West, Emma L, Munro, Peter M G, Thrasher, Adrian J, Matter, Karl, Balda, Maria S, Ali, Robin R

“…Cell-cell adhesion regulates the development and function of epithelia by providing mechanical support and by guiding cell proliferation and differentiation…”
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Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration by Ovando-Roche, Patrick, Georgiadis, Anastasios, Smith, Alexander J., Pearson, Rachael A., Ali, Robin R.

“…Purpose of Review A major cause of visual disorders is dysfunction and/or loss of the light-sensitive cells of the retina, the photoreceptors. To develop…”
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Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development by Lange, Clemens A K, Luhmann, Ulrich F O, Mowat, Freya M, Georgiadis, Anastasios, West, Emma L, Abrahams, Sabu, Sayed, Haroon, Powner, Michael B, Fruttiger, Marcus, Smith, Alexander J, Sowden, Jane C, Maxwell, Patrick H, Ali, Robin R, Bainbridge, James W B

“…Molecular oxygen is essential for the development, growth and survival of multicellular organisms. Hypoxic microenvironments and oxygen gradients are generated…”
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Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis by Bainbridge, James W.B, Mehat, Manjit S, Sundaram, Venki, Robbie, Scott J, Barker, Susie E, Ripamonti, Caterina, Georgiadis, Anastasios, Mowat, Freya M, Beattie, Stuart G, Gardner, Peter J, Feathers, Kecia L, Luong, Vy A, Yzer, Suzanne, Balaggan, Kamaljit, Viswanathan, Ananth, de Ravel, Thomy J.L, Casteels, Ingele, Holder, Graham E, Tyler, Nick, Fitzke, Fred W, Weleber, Richard G, Nardini, Marko, Moore, Anthony T, Thompson, Debra A, Petersen-Jones, Simon M, Michaelides, Michel, van den Born, L. Ingeborgh, Stockman, Andrew, Smith, Alexander J, Rubin, Gary, Ali, Robin R

“…Long-term follow-up of 12 persons with Leber's congenital amaurosis treated with gene therapy showed that about half of them had improvements in retinal…”
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AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of IRPGR/I-Associated X-Linked Retinitis Pigmentosa by Sladen, Paul E, Naeem, Arifa, Adefila-Ideozu, Toyin, Vermeule, Tijmen, Busson, Sophie L, Michaelides, Michel, Naylor, Stuart, Forbes, Alexandria, Lane, Amelia, Georgiadis, Anastasios

“…Variants within the Retinitis Pigmentosa GTPase regulator (RPGR) gene are the predominant cause of X-Linked Retinitis Pigmentosa (XLRP), a common and severe…”
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Letter to the editor: 'Emerging gene therapy products for RPGR -associated X-linked retinitis pigmentosa' by Georgiadis, Anastasios, Smith, Alexander J, Michaelides, Michel, Naylor, Stuart, Forbes, Alexandria

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Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua by Spathakis, Michail, Filidou, Eirini, Pappa, Chrysoula, Arzou, Bourazan Chalil, Georgiadis, Anastasios, Kontomanolis, Emmanuel N., Nikolettos, Nikos, Kolios, George, Galazios, George, Arvanitidis, Konstantinos

“…Purpose Miscarriage is one of the most common complications of pregnancy. Although chromosomal abnormalities of the embryo is a well-known cause of…”
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First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia by Michaelides, Michel, Hirji, Nashila, Wong, Sui Chien, Besirli, Cagri G., Zaman, Serena, Kumaran, Neruban, Georgiadis, Anastasios, Smith, Alexander J., Ripamonti, Caterina, Gottlob, Irene, Robson, Anthony G., Thiadens, Alberta, Henderson, Robert H., Fleck, Penny, Anglade, Eddy, Dong, Xiangwen, Capuano, George, Lu, Wentao, Berry, Pamela, Kane, Thomas, Naylor, Stuart, Georgiou, Michalis, Kalitzeos, Angelos, Ali, Robin R., Forbes, Alexandria, Bainbridge, James

“…•AAV8-hCARp.hCNGB3 is a gene therapy evaluated for CNGB3-associated achromatopsia.•This is a phase 1/2, open-label, nonrandomized, dose-escalation/expansion…”
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Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis by Zihni, Ceniz, Georgiadis, Anastasios, Ramsden, Conor M., Sanchez-Heras, Elena, Haas, Alexis J., Nommiste, Britta, Semenyuk, Olha, Bainbridge, James W.B., Coffey, Peter J., Smith, Alexander J., Ali, Robin R., Balda, Maria S., Matter, Karl

“…Phagocytosis requires actin dynamics, but whether actomyosin contractility plays a role in this morphodynamic process is unclear. Here, we show that in the…”
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RNAi‐mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration by Hippert, Claire, Graca, Anna B., Basche, Mark, Kalargyrou, Aikaterini A., Georgiadis, Anastasios, Ribeiro, Joana, Matsuyama, Ayako, Aghaizu, Nozie, Bainbridge, James W., Smith, Alexander J., Ali, Robin R., Pearson, Rachael A.

“…Gliosis is a complex process comprising upregulation of intermediate filament (IF) proteins, particularly glial fibrillary acidic protein (GFAP) and vimentin,…”
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Prevention of Photoreceptor Cell Loss in a Cln6 Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells by kleine Holthaus, Sophia-Martha, Ribeiro, Joana, Abelleira-Hervas, Laura, Pearson, Rachael A., Duran, Yanai, Georgiadis, Anastasios, Sampson, Robert D., Rizzi, Matteo, Hoke, Justin, Maswood, Ryea, Azam, Selina, Luhmann, Ulrich F.O., Smith, Alexander J., Mole, Sara E., Ali, Robin R.

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Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice by Georgiadis, Anastasios, Tschernutter, Marion, Bainbridge, James W B, Balaggan, Kamaljit S, Mowat, Freya, West, Emma L, Munro, Peter M G, Thrasher, Adrian J, Matter, Karl, Balda, Maria S, Ali, Robin R

“…[This corrects the article DOI: 10.1371/journal.pone.0015730.]…”
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