Search Results - "Anastasia S Proskurina"
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The Molecular Aspects of Functional Activity of Macrophage-Activating Factor GcMAF
Published in International journal of molecular sciences (12-12-2023)“…Group-specific component macrophage-activating factor (GcMAF) is the vitamin D -binding protein (DBP) deglycosylated at Thr . The protein is believed to…”
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The Macrophage Activator GcMAF-RF Enhances the Antitumor Effect of Karanahan Technology through Induction of M2–M1 Macrophage Reprogramming
Published in Journal of immunology research (29-02-2024)“…Macrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their…”
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The New General Biological Property of Stem-like Tumor Cells (Part II: Surface Molecules, Which Belongs to Distinctive Groups with Particular Functions, Form a Unique Pattern Characteristic of a Certain Type of Tumor Stem-like Cells)
Published in International journal of molecular sciences (13-12-2022)“…An ability of poorly differentiated cells of different genesis, including tumor stem-like cells (TSCs), to internalize extracellular double-stranded DNA…”
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Analysis of the Biological Properties of Blood Plasma Protein with GcMAF Functional Activity
Published in International journal of molecular sciences (22-07-2022)“…The main problem related to the studies focusing on group-specific component protein-derived macrophage-activating factor (GcMAF) is the lack of clarity about…”
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Impact of Double-Stranded RNA Internalization on Hematopoietic Progenitors and Krebs-2 Cells and Mechanism
Published in International journal of molecular sciences (01-03-2023)“…It is well-established that double-stranded RNA (dsRNA) exhibits noticeable radioprotective and radiotherapeutic effects. The experiments conducted in this…”
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Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats
Published in Current issues in molecular biology (28-09-2024)“…Vitamin D transporter (DBP) is a multifunctional protein. Site-specific deglycosylation results in its conversion to group-specific component protein-derived…”
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Oncolytic Effect of Adenoviruses Serotypes 5 and 6 Against U87 Glioblastoma Cancer Stem Cells
Published in Anticancer research (01-11-2019)“…Background/Aim: Oncolytic adenoviruses are promising therapeutic agents against both the bulk of tumor cells and cancer stem cells. The present study intended…”
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The new general biological property of stem-like tumor cells Part I. Peculiarities of the process of the double-stranded DNA fragments internalization into stem-like tumor cells
Published in Frontiers in genetics (08-09-2022)“…Stem-like tumor cells of ascites carcinoma Krebs-2 and Epstein-Barr virus-induced B-lymphoma were shown to possess the innate capability of binding and…”
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Cancer Stem Cells: Emergent Nature of Tumor Emergency
Published in Frontiers in genetics (16-11-2018)“…A functional analysis of 167 genes overexpressed in Krebs-2 tumor initiating cells was performed. In the first part of the study, the genes were analyzed for…”
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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma
Published in Cancer biology & medicine (01-08-2021)“…Glioma is a highly invasive tumor, frequently disposed in essential areas of the brain, which makes its surgical excision extremely difficult; meanwhile…”
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Effects of Recombinant Angiogenin on Collagen Fiber Formation and Angiogenesis in the Dermis of Wistar Rats
Published in Clinical, cosmetic and investigational dermatology (01-01-2021)“…The purpose of this study was to assess the capability of recombinant angiogenin isolated from yeasts to stimulate regenerative processes in the dermis of…”
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Identification of the xenograft and its ascendant sphere-forming cell line as belonging to EBV-induced lymphoma, and characterization of the status of sphere-forming cells
Published in Cancer cell international (06-05-2019)“…We have characterized the human cell line arised from the Epstein-Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation…”
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Experimental Comparison of the In Vivo Efficacy of Two Novel Anticancer Therapies
Published in Anticancer research (01-07-2021)“…Background/Aim: We compared the therapeutic efficacy of two recently developed experimental anticancer technologies: 1) in situ vaccination based on local…”
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Characterization of biological peculiarities of the radioprotective activity of double-stranded RNA isolated from Saccharomyces сerevisiae
Published in International journal of radiation biology (01-09-2020)“…Protection from ionizing radiation is the most important component in the curing malignant neoplasms, servicing atomic reactors, and resolving the situations…”
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Approbation of the Cancer Treatment Approach Based on the Eradication of TAMRA+ Cancer Stem Cells in a Model of Murine Cyclophosphamide Resistant Lymphosarcoma
Published in Anticancer research (01-02-2020)“…We previously have described the "3+1" tumors cure approach consisting of individual time schedule of cyclophosphamide and dsDNA preparation administrations…”
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Theoretical premises of a "three in one" therapeutic approach to treat immunogenic and nonimmunogenic cancers: a narrative review
Published in Translational cancer research (01-11-2021)“…We describe experimental and theoretical premises of a powerful cancer therapy based on the combination of three approaches. These include (I) vaccination…”
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Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma
Published in Oncotarget (19-06-2018)“…Krebs-2 solid carcinoma was cured using a new "3+1" strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization…”
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Identification of cancer stem cells and a strategy for their elimination
Published in Cancer biology & therapy (01-10-2014)“…It has been established previously that up to 40% of mouse CD34 + hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo…”
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Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers
Published in Journal of biomedical research (28-11-2022)“…To overcome immune tolerance to cancer, the immune system needs to be exposed to a multi-target action intervention. Here, we investigated the activating…”
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Delivery and processing of exogenous double-stranded DNA in mouse CD34+ hematopoietic progenitor cells and their cell cycle changes upon combined treatment with cyclophosphamide and double-stranded DNA
Published in Gene (10-10-2013)“…We previously reported that fragments of exogenous double-stranded DNA can be internalized by mouse bone marrow cells without any transfection. Our present…”
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