Search Results - "Anastacio da Costa Carvalho, Larissa"
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1
Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis
Published in The Journal of immunology (1950) (15-07-2021)“…Abstract Sepsis is a complex infectious syndrome in which neutrophil participation is crucial for patient survival. Neutrophils quickly sense and eliminate the…”
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2
Air Particulate Matter Induces Skin Barrier Dysfunction and Water Transport Alteration on a Reconstructed Human Epidermis Model
Published in Journal of investigative dermatology (01-12-2020)“…Knowing the damage that particulate matter (PM) can cause in skin is important for tightly controlling the release of air pollutants and preventing more…”
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3
Peroxiredoxin-2 represses NRAS-mutated melanoma cells invasion by modulating EMT markers
Published in Biomedicine & pharmacotherapy (01-08-2024)“…The second most common mutation in melanoma occurs in NRAS oncogene, being a more aggressive disease that has no effective approved treatment. Besides,…”
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Upregulation of the novel lncRNA U731166 is associated with migration, invasion and vemurafenib resistance in melanoma
Published in Journal of cellular and molecular medicine (01-02-2022)“…Our previous work using a melanoma progression model composed of melanocytic cells (melanocytes, primary and metastatic melanoma samples) demonstrated various…”
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TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors
Published in Pharmacological research (01-11-2021)“…In melanomas, therapy resistance can arise due to a combination of genetic, epigenetic and phenotypic mechanisms. Due to its crucial role in DNA supercoil…”
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Modeling Melanoma Heterogeneity In Vitro: Redox, Resistance and Pigmentation Profiles
Published in Antioxidants (01-05-2024)“…Microenvironment and transcriptional plasticity generate subpopulations within the tumor, and the use of BRAF inhibitors (BRAFis) contributes to the rise and…”
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Acral melanoma: new insights into the immune and genomic landscape
Published in Neoplasia (New York, N.Y.) (01-12-2023)“…Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique…”
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