Search Results - "Ananthakrishnan, AN"

Epidemiology and risk factors for IBD by Ananthakrishnan, Ashwin N.

“…Key Points Crohn's disease and ulcerative colitis are complex immunologically mediated diseases that arise due to a dysregulated immune response to commensal…”
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ACG Clinical Guideline: Ulcerative Colitis in Adults by Rubin, David T, Ananthakrishnan, Ashwin N, Siegel, Corey A, Sauer, Bryan G, Long, Millie D

“…Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the preferred approach to the management of adults with UC and…”
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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease by Jostins, Luke, Ripke, Stephan, Weersma, Rinse K., Duerr, Richard H., McGovern, Dermot P., Hui, Ken Y., Lee, James C., Philip Schumm, L., Sharma, Yashoda, Anderson, Carl A., Mitrovic, Mitja, Ning, Kaida, Cleynen, Isabelle, Theatre, Emilie, Raychaudhuri, Soumya, Goyette, Philippe, Wei, Zhi, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Andrews, Jane M., Baidoo, Leonard, Balschun, Tobias, Bampton, Peter A., Bitton, Alain, Boucher, Gabrielle, Brand, Stephan, Büning, Carsten, Cohain, Ariella, Cichon, Sven, D’Amato, Mauro, De Jong, Dirk, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Ferguson, Lynnette R., Franchimont, Denis, Fransen, Karin, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hedl, Matija, Hu, Xinli, Karlsen, Tom H., Kupcinskas, Limas, Kugathasan, Subra, Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lees, Charlie W., Louis, Edouard, Mahy, Gillian, Mansfield, John, Morgan, Angharad R., Mowat, Craig, Newman, William, Palmieri, Orazio, Ponsioen, Cyriel Y., Potocnik, Uros, Prescott, Natalie J., Rotter, Jerome I., Sanderson, Jeremy D., Sans, Miquel, Schreiber, Stefan, Simms, Lisa A., Sventoraityte, Jurgita, Targan, Stephan R., Taylor, Kent D., Tremelling, Mark, Verspaget, Hein W., De Vos, Martine, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Xavier, Ramnik J., Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhao, Hongyu, Silverberg, Mark S., Annese, Vito, Hakonarson, Hakon, Brant, Steven R., Radford-Smith, Graham, Mathew, Christopher G., Rioux, John D., Schadt, Eric E., Daly, Mark J., Franke, Andre, Parkes, Miles, Vermeire, Severine, Barrett, Jeffrey C., Cho, Judy H

“…A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease,…”
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Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease by Walker, Gareth J, Harrison, James W, Heap, Graham A, Voskuil, Michiel D, Andersen, Vibeke, Anderson, Carl A, Ananthakrishnan, Ashwin N, Barrett, Jeffrey C, Beaugerie, Laurent, Bewshea, Claire M, Cole, Andy T, Cummings, Fraser R, Daly, Mark J, Ellul, Pierre, Fedorak, Richard N, Festen, Eleonora A. M, Florin, Timothy H, Gaya, Daniel R, Halfvarson, Jonas, Hart, Ailsa L, Heerasing, Neel M, Hendy, Peter, Irving, Peter M, Jones, Samuel E, Koskela, Jukka, Lindsay, James O, Mansfield, John C, McGovern, Dermot, Parkes, Miles, Pollok, Richard C. G, Ramakrishnan, Subramaniam, Rampton, David S, Rivas, Manuel A, Russell, Richard K, Schultz, Michael, Sebastian, Shaji, Seksik, Philippe, Singh, Abhey, So, Kenji, Sokol, Harry, Subramaniam, Kavitha, Todd, Anthony, Annese, Vito, Weersma, Rinse K, Xavier, Ramnik, Ward, Rebecca, Weedon, Michael N, Goodhand, James R, Kennedy, Nicholas A, Ahmad, Tariq

“…IMPORTANCE: Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry…”
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Clostridium difficile and inflammatory bowel disease by Issa, Mazen, Ananthakrishnan, Ashwin N., Binion, David G.

“…Clostridium difficile colitis has doubled in North America over the past 5 years and recent reports have demonstrated an increase in incidence and severity of…”
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Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis by Liu, Po-Hong, Burke, Kristin E., Ananthakrishnan, Ashwin N., Lochhead, Paul, Olen, Ola, Ludvigsson, Jonas F., Richter, James M., Chan, Andrew T., Khalili, Hamed

“…Obesity promotes intestinal inflammation and might contribute to the pathogenesis of inflammatory bowel disease. We examined the association between obesity…”
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Hormone Therapy Increases Risk of Ulcerative Colitis but not Crohn's Disease by Khalili, Hamed, Higuchi, Leslie M, Ananthakrishnan, Ashwin N, Manson, JoAnn E, Feskanich, Diane, Richter, James M, Fuchs, Charles S, Chan, Andrew T

“…Background & Aims Estrogen has been proposed to modulate gut inflammation through an effect on estrogen receptors found on gastrointestinal epithelial and…”
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Dietary Gluten Intake Is Not Associated With Risk of Inflammatory Bowel Disease in US Adults Without Celiac Disease by Lopes, Emily W., Lebwohl, Benjamin, Burke, Kristin E., Ivey, Kerry L., Ananthakrishnan, Ashwin N., Lochhead, Paul, Richter, James M., Ludvigsson, Jonas F., Willett, Walter C., Chan, Andrew T., Khalili, Hamed

“…Diet is thought to play a role in the development of inflammatory bowel disease (IBD), though it is unknown whether gluten intake confers risk of IBD. The aim…”
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Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis—Results From the Nurses’ Health Study by Burke, Kristin E., Ananthakrishnan, Ashwin N., Lochhead, Paul, Liu, Po-Hong, Olen, Ola, Ludvigsson, Jonas F., Richter, James M., Tworoger, Shelley S., Chan, Andrew T., Khalili, Hamed

“…Microscopic colitis is a chronic inflammatory disorder of the colon primarily affecting postmenopausal women. However, the relation between hormonal…”
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IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease by Simon, Tracey G, Van Der Sloot, Kimberley W J, Chin, Samantha B, Joshi, Amit D, Lochhead, Paul, Ananthakrishnan, Ashwin N, Xavier, Ramnik, Chung, Raymond T, Khalili, Hamed

“…Abstract Background Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized comorbidity in Crohn's disease (CD), but the mechanisms are poorly…”
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Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease by Ananthakrishnan, A. N., Guzman-Perez, R., Gainer, V., Cai, T., Churchill, S., Kohane, I., Plenge, R. M., Murphy, S.

“…Summary Background The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well…”
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Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study by Liu, Po-Hong, Lebwohl, Benjamin, Burke, Kristin E, Ivey, Kerry L, Ananthakrishnan, Ashwin N, Lochhead, Paul, Olen, Ola, Ludvigsson, Jonas F, Richter, James M, Chan, Andrew T, Khalili, Hamed

“…Microscopic colitis is a common cause of chronic watery diarrhea among the elderly. Although the prevalence of celiac disease appears to be higher in patients…”
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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis by Rivas, Manuel A., Graham, Daniel, Sulem, Patrick, Stevens, Christine, Desch, A. Nicole, Goyette, Philippe, Gudbjartsson, Daniel, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Degenhardt, Frauke, Mucha, Sören, Kurki, Mitja I., Li, Dalin, D’Amato, Mauro, Annese, Vito, Vermeire, Severine, Weersma, Rinse K., Halfvarson, Jonas, Paavola-Sakki, Paulina, Lappalainen, Maarit, Lek, Monkol, Cummings, Beryl, Tukiainen, Taru, Haritunians, Talin, Halme, Leena, Koskinen, Lotta L. E., Ananthakrishnan, Ashwin N., Luo, Yang, Heap, Graham A., Visschedijk, Marijn C., MacArthur, Daniel G., Neale, Benjamin M., Ahmad, Tariq, Anderson, Carl A., Brant, Steven R., Duerr, Richard H., Silverberg, Mark S., Cho, Judy H, Palotie, Aarno, Saavalainen, Päivi, Kontula, Kimmo, Färkkilä, Martti, McGovern, Dermot P. B., Franke, Andre, Stefansson, Kari, Rioux, John D., Xavier, Ramnik J., Daly, Mark J.

“…Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a…”
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Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases by Ananthakrishnan, A. N., Cagan, A., Gainer, V. S., Cheng, S.‐C., Cai, T., Szolovits, P., Shaw, S. Y., Churchill, S., Karlson, E. W., Murphy, S. N., Kohane, I., Liao, K. P.

“…Summary Background Patients with inflammatory bowel diseases (IBD) have an increased risk of clostridium difficile infection (CDI). Cathelicidins are…”
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Genetic risk factors for Clostridium difficile infection in ulcerative colitis by Ananthakrishnan, A. N., Oxford, E. C., Nguyen, D. D., Sauk, J., Yajnik, V., Xavier, R. J.

“…Summary Background Patients with inflammatory bowel disease (IBD) are at higher risk for Clostridium difficile infection (CDI). Disruption of gut microbiome…”
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Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women by Burke, Kristin E, Ananthakrishnan, Ashwin N, Lochhead, Paul, Olen, Ola, Ludvigsson, Jonas F, Richter, James M, Chan, Andrew T, Khalili, Hamed

“…Abstract Background Long-term data on the influence of smoking on risk of microscopic colitis are limited. We therefore sought to examine and characterize the…”
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Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women Without Celiac Disease: A Prospective Cohort Study (vol 114, 2019) by Liu, P-H, Lebwohl, B, Burke, KE, Ivey, KL, Ananthakrishnan, AN, Lochhead, P, Olen, O, Ludvigsson, JF, Richter, JM, Chan, AT

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Smoking Behaviour Changes After Diagnosis of Inflammatory Bowel Disease and Risk of All-cause Mortality by Hua, Xinwei, Lopes, Emily W, Burke, Kristin E, Ananthakrishnan, Ashwin N, Richter, James M, Lo, Chun-Han, Lochhead, Paul, Chan, Andrew T, Khalili, Hamed

“…Abstract Background and Aims We examined smoking behaviour changes after diagnoses of Crohn’s disease [CD] and ulcerative colitis [UC] and evaluated their…”
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Correction: Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women Without Celiac Disease: A Prospective Cohort Study by Liu, Po-Hong, Lebwohl, Benjamin, Burke, Kristin E, Ivey, Kerry L, Ananthakrishnan, Ashwin N, Lochhead, Paul, Olen, Ola, Ludvigsson, Jonas F, Richter, James M, Chan, Andrew T, Khalili, Hamed

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Personalizing therapy for inflammatory bowel diseases by Ananthakrishnan, Ashwin N

“…Inflammatory bowel diseases (IBDs; e.g., Crohn's disease [CD] and ulcerative colitis [UC]) are chronic immunologically mediated diseases characterized by…”
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