Search Results - "Anandalakshmi, Venkatraman"

Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp by Venkatraman, Anandalakshmi, Murugan, Elavazhagan, Lin, Shu Jun, Peh, Gary Swee Lim, Rajamani, Lakshminarayanan, Mehta, Jodhbir S.

“…Protein aggregation has been one of the leading triggers of various disease conditions, such as Alzheimer’s, Parkinson’s and other amyloidosis. TGFBI…”
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Molecular mechanisms of amyloid disaggregation by Low, Kimberly Jia Yi, Venkatraman, Anandalakshmi, Mehta, Jodhbir S., Pervushin, Konstantin

“…[Display omitted] •Importance of disaggregation mechanism and innate disaggregation in living systems.•Different types and mechanism of disaggregation reported…”
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Genotypic Homogeneity in Distinctive Transforming Growth Factor-Beta Induced (TGFBI) Protein Phenotypes by Han, Sang Beom, Anandalakshmi, Venkatraman, Wong, Chee Wai, Ng, Si Rui, Mehta, Jodhbir S

“…To evaluate the distribution of the transforming growth factor-beta induced (TGFBI) corneal dystrophies in a multi-ethnic population in Singapore, and to…”
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Clinical and Genetic Aspects of the TGFBI -associated Corneal Dystrophies by Lakshminarayanan, R., PhD, Chaurasia, Shyam S., PhD, Anandalakshmi, Venkatraman, MSc, Chai, Shu-Ming, FRCS(Ed), Murugan, Elavazhagan, PhD, Vithana, Eranga N., PhD, Beuerman, Roger W., PhD, Mehta, Jodhbir S., FRCS(Ed)

“…Abstract Corneal dystrophies are a group of inherited disorders localized to various layers of the cornea that affect corneal transparency and visual acuity…”
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Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy by Venkatraman, Anandalakshmi, Duong-Thi, Minh-Dao, Pervushin, Konstantin, Ohlson, Sten, Mehta, Jodhbir Singh

“…[Display omitted] •Corneal stromal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene and affect the corneal stroma and…”
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Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2) by Vithana, Eranga N, Morgan, Patricio, Sundaresan, Periasamy, Ebenezer, Neil D, Tan, Donald T H, Mohamed, Moin D, Anand, Seema, Khine, Khin O, Venkataraman, Divya, Yong, Victor H K, Salto-Tellez, Manuel, Venkatraman, Anandalakshmi, Guo, Ke, Hemadevi, Boomiraj, Srinivasan, Muthiah, Prajna, Venkatesh, Khine, Myint, Casey, Joseph R, Inglehearn, Chris F, Aung, Tin

“…Congenital hereditary endothelial dystrophy (CHED) is a heritable, bilateral corneal dystrophy characterized by corneal opacification and nystagmus. We…”
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Effects of Rho-Associated Kinase (Rock) Inhibitors (Alternative to Y-27632) on Primary Human Corneal Endothelial Cells by Peh, Gary S L, Bandeira, Francisco, Neo, Dawn, Adnan, Khadijah, Hartono, Yossa, Ong, Hon Shing, Naso, Sacha, Venkatraman, Anandalakshmi, Gomes, José A P, Kocaba, Viridiana, Mehta, Jodhbir S

“…(1) Rho-associated coiled-coil protein kinase (ROCK) signaling cascade impacts a wide array of cellular events. For cellular therapeutics, scalable expansion…”
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Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging by Anandalakshmi, Venkatraman, Hochart, Guillaume, Bonnel, David, Stauber, Jonathan, Shimmura, Shigeto, Lakshminarayanan, Rajamani, Pervushin, Konstantin, Mehta, Jodhbir S.

“…Stromal corneal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene. The mutant TGFBIp is prone to protein aggregation and…”
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Release of frustration drives corneal amyloid disaggregation by brain chaperone by Low, Jia Yi Kimberly, Shi, Xiangyan, Anandalakshmi, Venkatraman, Neo, Dawn, Peh, Gary Swee Lim, Koh, Siew Kwan, Zhou, Lei, Abdul Rahim, M. K., Boo, Ketti, Lee, JiaXuan, Mohanram, Harini, Alag, Reema, Mu, Yuguang, Mehta, Jodhbir S., Pervushin, Konstantin

“…TGFBI-related corneal dystrophy (CD) is characterized by the accumulation of insoluble protein deposits in the corneal tissues, eventually leading to…”
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Biochemical Properties and Aggregation Propensity of Transforming Growth Factor-Induced Protein (TGFBIp) and the Amyloid Forming Mutants by Lakshminarayanan, R., PhD, Chaurasia, Shyam S., PhD, Murugan, Elavazhagan, PhD, Venkatraman, Anandalakshmi, MSc, Chai, Shu-Ming, FRCS(Ed), Vithana, Eranga N., PhD, Beuerman, Roger W., PhD, Mehta, Jodhbir S., FRCS(Ed)

“…Abstract TGFBI -associated corneal dystrophies are characterized by accumulation of insoluble deposits of the mutant protein transforming growth factor…”
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In vivo liquid–liquid phase separation protects amyloidogenic and aggregation‐prone peptides during overexpression in Escherichia coli by Gabryelczyk, Bartosz, Alag, Reema, Philips, Margaret, Low, Kimberly, Venkatraman, Anandalakshmi, Kannaian, Bhuvaneswari, Shi, Xiangyan, Linder, Markus, Pervushin, Konstantin, Miserez, Ali

“…Studying pathogenic effects of amyloids requires homogeneous amyloidogenic peptide samples. Recombinant production of these peptides is challenging due to…”
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Automatic segmentation of corneal deposits from corneal stromal dystrophy images via deep learning by Deshmukh, Mihir, Liu, Yu-Chi, Rim, Tyler Hyungtaek, Venkatraman, Anandalakshmi, Davidson, Matthew, Yu, Marco, Kim, Hong Seok, Lee, Geunyoung, Jun, Ikhyun, Mehta, Jodhbir S., Kim, Eung Kweon

“…Granular dystrophy is the most common stromal dystrophy. To perform automated segmentation of corneal stromal deposits, we trained and tested a deep learning…”
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Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients by Anandalakshmi, Venkatraman, Murugan, Elavazhagan, Leng, Eunice Goh Tze, Ting, Lim Wei, Chaurasia, Shyam S, Yamazaki, Toshio, Nagashima, Toshio, George, Benjamin Lawrence, Peh, Gary Swee Lim, Pervushin, Konstantin, Lakshminarayanan, Rajamani, Mehta, Jodhbir S

“…Corneal stromal dystrophies are a group of genetic disorders that may be caused by mutations in the transforming growth factor β-induced ( ) gene which results…”
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Proteomic Analysis of Amyloid Corneal Aggregates from TGFBI-H626R Lattice Corneal Dystrophy Patient Implicates Serine-Protease HTRA1 in Mutation-Specific Pathogenesis of TGFBIp by Venkatraman, Anandalakshmi, Dutta, Bamaprasad, Murugan, Elavazhagan, Piliang, Hao, Lakshminaryanan, Rajamani, Sook Yee, Anita Chan, Pervushin, Konstantin V, Sze, Siu Kwan, Mehta, Jodhbir S

“…TGFBI-associated corneal dystrophies are inherited disorders caused by TGFBI gene variants that promote deposition of mutant protein (TGFBIp) as insoluble…”
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Matrix‐Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI‐H626R and TGFBI‐R124C Mutations by Venkatraman, Anandalakshmi, Hochart, Guillaume, Bonnel, David, Stauber, Jonathan, Shimmura, Shigeto, Rajamani, Lakshminaryanan, Pervushin, Konstantin, Mehta, Jodhbir S.

“…Scope The purpose of this study is to identify and visualize the spatial distribution of proteins present in amyloid corneal deposits of TGFBI‐CD patients…”
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Effects of Rho-Associated Kinase on Primary Human Corneal Endothelial Cells by Peh, Gary S. L, Bandeira, Francisco, Neo, Dawn, Adnan, Khadijah, Hartono, Yossa, Ong, Hon Shing, Naso, Sacha, Venkatraman, Anandalakshmi, Gomes, José A. P, Kocaba, Viridiana, Mehta, Jodhbir S

“…(1) Rho-associated coiled-coil protein kinase (ROCK) signaling cascade impacts a wide array of cellular events. For cellular therapeutics, scalable expansion…”
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Association of LOXL1 Gene Polymorphisms with Pseudoexfoliation in the Japanese by Ozaki, Mineo, Lee, Kelvin Y. C, Vithana, Eranga N, Yong, Victor H, Thalamuthu, Anbupalam, Mizoguchi, Takanori, Venkatraman, Anandalakshmi, Aung, Tin

“…The single nucleotide polymorphisms (SNPs) rs1048661, rs3825942, and rs2165241 within the LOXL1 gene were recently found to confer risk of pseudoexfoliation…”
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SLC4A11 mutations in Fuchs endothelial corneal dystrophy by Vithana, Eranga N., Morgan, Patricio E., Ramprasad, Vedam, Tan, Donald T.H., Yong, Victor H.K, Venkataraman, Divya, Venkatraman, Anandalakshmi, Yam, Gary H.F., Nagasamy, Soumittra, Law, Ricky W.K., Rajagopal, Rama, Pang, Chi P., Kumaramanickevel, Govindsamy, Casey, Joseph R., Aung, Tin

“…The endothelial (posterior) corneal dystrophies, which result from primary endothelial dysfunction, include Fuchs endothelial corneal dystrophy (FECD),…”
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Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line by Liu, Jun, Seet, Li-Fong, Koh, Li Wei, Venkatraman, Anandalakshmi, Venkataraman, Divya, Mohan, Rajiv R, Praetorius, Jeppe, Bonanno, Joseph A, Aung, Tin, Vithana, Eranga N

“…To investigate the effects of SLC4A11 gene depletion in human corneal endothelial cells. To achieve stable downregulation of SLC4A11 gene expression in…”
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pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants by Murugan, Elavazhagan, Venkatraman, Anandalakshmi, Lei, Zhou, Mouvet, Victoria, Rui Yi Lim, Rayne, Muruganantham, Nandhakumar, Goh, Eunice, Swee Lim Peh, Gary, Beuerman, Roger W., Chaurasia, Shyam S., Rajamani, Lakshminarayanan, Mehta, Jodhbir S.

“…Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4 th…”
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