Search Results - "Anand, Jay Ramanlal"
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PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling
Published in Nucleic acids research (24-10-2024)“…RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs)…”
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Journal Article -
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Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma
Published in Nature communications (04-03-2024)“…Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that…”
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Journal Article -
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Biochemical and Signaling Pathways for Repair of Topoisomerase Ii-Mediated Dna Damage
Published 01-01-2019“…Genome maintenance systems detect and resolve DNA damage, and prevent mutations that can lead to cancer. The role of tumor suppressor p53, a transcription…”
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Dissertation