Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats. 28 male rats were divi...

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Published in:	BMC urology Vol. 18; no. 1; pp. 107 - 11
Main Authors:	Jahan, Sarwat, Munawar, Asma, Razak, Suhail, Anam, Sara, Ain, Qurat Ul, Ullah, Hizb, Afsar, Tayyaba, Abulmeaty, Mahmoud, Almajwal, Ali
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 21-11-2018 BioMed Central BMC
Subjects:	Animals Antineoplastic Agents - toxicity Antioxidants Apoptosis Chemotherapy Cisplatin Cisplatin - toxicity Comet assay Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - physiology Epithelial cells Histology Infertility Injection Kinases Lipid peroxidation Lipids Male Neoplasia Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Peritoneum Platinum Random Allocation Rats Rats, Sprague-Dawley Reproduction - drug effects Reproduction - physiology Reproductive organs Rodents Rutin Rutin - pharmacology Solid tumors Sperm Sperm Motility - drug effects Sperm Motility - physiology Spermatids Spermatocytes Spermatogenesis Spermatogonia Spermatozoa - drug effects Spermatozoa - metabolism Spermatozoa - pathology Studies Testes Testis - drug effects Testis - metabolism Testis - pathology Testosterone Thiobarbituric acid Toxicity Tumors Urology Antioxidants Testosterone Histology Rutin Cisplatin Comet assay
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Summary:	Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats. 28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7 mg/kg) on day first and received saline for next 13 days. Third group received i.p injection of cisplatin at day one and treated with rutin (75 mg/kg) orally for next 13 days. Fourth group was treated with rutin orally for 13 days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters. Cisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues, and change of the intra-testicular testosterone concentrations. Rutin co-treatment resulted in reversing cisplatin effect on DNA damage, sperm count, histological and biochemical parameters. These results indicated that rutin co-treatment could ameliorate cisplatin-induced reproductive toxicity in male rats.
ISSN:	1471-2490 1471-2490
DOI:	10.1186/s12894-018-0421-9