Search Results - "Ana Silvia G. Lima"

The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells by Almeida, Luciana Yamamoto de, Pereira-Martins, Diego A., Weinhäuser, Isabel, Ortiz, César, Cândido, Larissa A., Lange, Ana Paula, De Abreu, Nayara F., Mendonza, Sílvia E. S., de Deus Wagatsuma, Virgínia M., Do Nascimento, Mariane C., Paiva, Helder H., Alves-Paiva, Raquel M., Bonaldo, Camila C. O. M., Nascimento, Daniele C., Alves-Filho, José C., Scheucher, Priscila S., Lima, Ana Sílvia G., Schuringa, Jan Jacob, Ammantuna, Emanuele, Ottone, Tiziana, Noguera, Nelida I., Araujo, Cleide L., Rego, Eduardo M.

“…In approximately 15% of patients with acute myeloid leukemia (AML), total and phosphorylated EGFR proteins have been reported to be increased compared to…”
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Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway by de Figueiredo-Pontes, Lorena L, Assis, Patricia A, Santana-Lemos, Bárbara A A, Jácomo, Rafael H, Lima, Ana Sílvia G, Garcia, Aglair B, Thomé, Carolina H, Araújo, Amélia G, Panepucci, Rodrigo A, Zago, Marco A, Nagler, Arnon, Falcão, Roberto P, Rego, Eduardo M

“…Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ)…”
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ABSENT CD33 IN AML PATIENTS: FROM DIAGNOSIS TO FOLLOW-UPS by Leticia O. Marani, Amanda Costa, Fernanda B. Silva, Maria Izabel A. Madeira, Priscila S. Scheucher, Josiane L.S. Schiavinato, Ana Silvia G. Lima, Katia B.B. Pagnano, Bruno K. Duarte, Sylvie Freeman, Eduardo M. Rego, Fabiola Traina, Lorena L. Figueiredo-Pontes

“…Background: Despite recent advances and development of new therapeutic targets and personalized medicine, acute myeloid leukemia (AML) treatment remains…”
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Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model by Assis, Patricia A, De Figueiredo-Pontes, Lorena L, Lima, Ana Silvia G, Leão, Vitor, Cândido, Larissa A, Pintão, Carolina T, Garcia, Aglair B, Saggioro, Fabiano P, Panepucci, Rodrigo A, Chahud, Fernando, Nagler, Arnon, Falcão, Roberto P, Rego, Eduardo M

“…Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β)…”
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Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia by Jácomo, Rafael H., Santana-Lemos, Barbara A., Lima, Ana Silvia G., Assis, Patricia A., Lange, Ana Paula A., Figueiredo-Pontes, Lorena L., Oliveira, Luciana O., Bassi, Sarah C., Benício, Mariana T.L., Baggio, Márcia S., Garcia, Aglair B., Falcão, Roberto P., Rego, Eduardo M.

“…Increased fibrinolysis is an important component of acute promyelocytic leukemia (APL) bleeding diathesis. APL blasts overexpress annexin II (ANXII), a…”
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IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia by Coelho-Silva, Juan Luiz, Machado-Neto, João Agostinho, Fernandes, Jaqueline Cristina, de Lima, Ana Silvia G, Scheucher, Priscila Santos, Rego, Eduardo Magalhães, Traina, Fabiola

“…Background : Despite the growing knowledge about acute myeloid leukemia (AML) pathophysiology, it remains a disease with high mortality rates, and the early…”
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Cytokine Profiles in Acute Promyelocytic Leukemia Patients at Diagnosis and during the Treatment with Acid All-Trans Retinoic and Anthracyclines by Almeida, Luciana Yamamoto, Scheucher, Priscila S, de Lima, Ana Silvia G, Bassi, Sarah C, Baggio, Márcia S, Weinhäuser, Isabel, Lange, Ana Paula, Pereira-Martins, Diego Antonio, Rego, Eduardo Magalhães

“…INTRODUCTION: Acute promyelocytic leukemia (APL) cells have been shown to secrete IL-1β, TNFα and IL-6 in vitro and particularly the first one has a relevant…”
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Flow Cytometry Quantification of Leukemic Stem Cells Is Associated with Risk Stratification and May Be Useful for Minimal Residual Disease in Acute Myeloid Leukemia by Figueiredo Pontes, Lorena Lobo, Dalmazzo, Leandro F., de Oliveira, Luciana Correa Oliveira, Santana-Lemos, Bárbara A, Furtado, Felipe M, Lucena-Araujo, Antonio R, Benício, Mariana Tereza Lira, Oliveira, Fabio Morato, de Lima, Ana Silvia G, Garcia, Aglair Bergamo, Falcao, Roberto P., Rego, Eduardo M.

“…Abstract 1470 Investigation of minimal residual disease (MRD) after remission induction (RI) therapy provides important information for risk assessment in…”
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Vitamin E Succinate Induces Remission and Prolongs Survival in a Syngenic Transplant Model of Acute Promyelocytic Leukemia by Lima, Rodrigo S. Abreu e, Scheucher, Priscila S., Santana, Bárbara A.A., Pintão, Ana Carolina T., Lima, Ana Sílvia G., Garcia, Aglair B., Saggioro, Fabiano P., Falcao, Roberto P., Rego, Eduardo M.

“…Vitamin E Succinate (VES) is a semisinthetic analogue of vitamin E with pro-apoptotic activity against several tumor cell lines and it has reported that the…”
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Correlations of ΔNp73 and TAp73 Expression Pattern with Specific Genetic Rearrengents in AML by Araújo, Antonio Roberto L., Lima, Ana Silvia G., Panepucci, Rodrigo A., Rego, Eduardo M.

“…The p73 protein is a p53 homolog and acts on cell cycle and apoptosis regulation. Resistance to apoptosis is a common feature of Acute Myeloid Leukemia (AML),…”
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ΔNp73 /TAp73 Expression Ratio Is Associated with Ara-C-Induced Apoptosis Resistance in Acute Myeloid Leukemia by Araújo, Antonio Roberto L., Panepucci, Rodrigo A., Jacomo, Rafael H., Souza, Guilherme A., Araújo, Amélia G., Lima, Ana Silvia G., Garcia, Aglair B., Falcao, Roberto P., Rego, Eduardo M.

“…The p73, a homologue to the tumor suppressor gene p53, is involved in oncogenesis, although its specific role remains unclear. This gene has two distinct…”
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Halofuginone Exerts Antiproliferative and Antiangiogenic Actions on Acute Promyelocytic Leukemia Cells through Modulation of the TGFβ Pathway by Figueiredo-Pontes, Lorena L., Lima, Ana Silvia G., Santana-Lemos, Barbara A., Lange, Ana Paula A., Oliveira, Luciana C., Garcia, Aglair B., Baggio, Marcia S., Goes, Amelia A., Panepucci, Rodrigo A., Zago, Marco A., Nagler, Arnon, Falcao, Roberto P., Rego, Eduardo M.

“…The effects of TGFβ signaling in tumorigenesis is both cell type and context-dependent. Although this cytokine may behave as tumor suppressor in early stages…”
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Distinct Profile of FLT3 Mutations in Brazil by Souza, Danielle L.C.F., Lima, Ana Silvia G., Santos, Guilherme A.A., Melato, Lidiane C., Dore, Adriana I., Silva, Dirceu E., Ismael, Sebastião, Silva, Wilson A., Rego, Eduardo M.

“…Mutations in the tyrosine kinase receptor FLT3 are the most common molecular abnormality in acute myeloid leukemia (AML) being detected in about 30% of AML…”
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Coexpression of PML/RARα and AML1/ETO Leads to ATRA Resistance In Vivo in Acute Promyelocytic Leukemia by Abreu e Lima, Rodrigo S., Baruffi, Marcelo R., Lima, Ana Silvia G., Figueiredo, Lorena L., Falcao, Roberto P., de Lourdes F. Chauffaille, Maria, Rego, Eduardo M.

“…Acute promyelocytic leukemia (APL) associated with the t(15;17)/PML/RARα and AML with t(8;21)/AML1/ETO are AML subtypes characterized by distinct…”
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Histone Deacetylase Inhibitors and Filgrastim Do Not Synergize with ATRA in the Induction of Changes of Acute Promyelocytic Leukemia Cells Adhesive Properties by De Santis, Gil C., Moreno, Suzana E., Teixera, Hamilton L.G., Lima, Ana Silvia G., Garcia, Aglair B., Falcao, Roberto P., Cunha, Fernando Q., Rego, Eduardo M.

“…All-trans retinoic acid (ATRA) in combination with anthracyclines induces long term complete remission in approximately 80% of patients with acute…”
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Alpha-Tocopherol Induces Apoptosis in Acute Promyelocytic Leukemia Cells through a P53-Independent Pathway by Freitas, Rosana A., Lima, Ana Silvia G., Garcia, Aglair B., Teixeira, Hamilton L.G., Lima, Rodrigo S.A., Meirelles, Monica S.S., Vannucchi, Helio, Falcao, Roberto P., Rego, Eduardo M.

“…Succinate of α tocopherol (VES) is a derivative of vitamin E with well-known antioxidant and pro-apoptotic activities. It has been demonstrated that VES…”
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Hematological features and expression profile of myeloid antigens of acute promyelocytic leukemia patients: analysis of prognostic factors for development of the retinoic acid syndrome by Santos, Flávia Leite Souza, Dore, Adriana I, Lima, Ana Sílvia G, Garcia, Aglair B, Zago, Marco A, Rizzatti, Edgar G, Elias, Jr, Jorge, Falcão, Roberto Passetto, Rego, Eduardo Magalhães

“…Acute Promyelocytic Leukemia (APL) is characterized by its good response to treatment with all trans retinoic acid (ATRA). However, some patients receiving…”
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Características hematológicas e perfil de expressão de antígenos mielóides de pacientes com leucemia promielocítica aguda: análise de fatores prognósticos para o desenvolvimento da síndrome do ácido retinóico by Santos, Flávia Leite Souza, Dore, Adriana I., Lima, Ana Sílvia G., Garcia, Aglair B., Zago, Marco A., Rizzatti, Edgar G., Elias Jr, Jorge, Falcão, Roberto Passetto, Rego, Eduardo Magalhães

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