Search Results - "Ana P. Miranda"
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Forecasting Model of Silicon Content in Molten Iron Using Wavelet Decomposition and Artificial Neural Networks
Published in Metals (Basel ) (01-07-2021)“…Silicon content forecasting models have been requested by the operational team to anticipate necessary actions during the blast furnace operation when…”
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Activation of NPY Receptors in the BLA Inhibits Projections to the Bed Nucleus of the Stria Terminalis and Buffers Stress-Induced Decreases in Social Interaction in Male Rats
Published in The Journal of neuroscience (21-08-2024)“…Neuropeptide Y (NPY) increases resilience and buffers behavioral stress responses in male rats in part through decreasing the excitability of principal output…”
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3
The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response
Published in Frontiers in cellular neuroscience (21-08-2019)“…Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory…”
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4
Zinc deficiency disrupts pain signaling promoting nociceptive but not inflammatory pain in mice
Published in Anais da Academia Brasileira de Ciências (01-01-2023)“…Abstract Zinc (Zn) is an essential micronutrient involved in the physiology of nervous system and pain modulation. There is little evidence for the role of…”
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Geissoschizoline, a promising alkaloid for Alzheimer’s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking
Published in Bioorganic chemistry (01-11-2020)“…[Display omitted] •Geissoschizoline is a potent inhibitor of both humans AChE and BChE.•Geissoschizoline plays a promising anti-inflammatory role.•It reduces…”
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Antinociceptive and anti-inflammatory effects of a Geissospermum vellosii stem bark fraction
Published in Anais da Academia Brasileira de Ciências (01-03-2016)“…Geissospermum vellosii (Pao pereira) is a Brazilian tree whose stem barks are rich in indole alkaloids that present intense anticholinesterase activity. The…”
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The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice
Published in European journal of pharmacology (05-08-2019)“…Painful diabetic neuropathy (PDN) is a serious symptom that compromises quality of life and remains without effective pharmacological treatment. The transient…”
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Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)
Published in Bioorganic & medicinal chemistry letters (01-09-2009)“…A set of six azaheterocycles were designed as conformationnaly-constrained N-acylhydrazones and tested as analgesics…”
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Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes
Published in Bioorganic & medicinal chemistry (2009)“…We describe herein the discovery of LASSBio-1135 ( 3a) as a novel in vivo antinociceptive and anti-inflammatory symbiotic prototype that act as selective…”
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Flavonoids and fractions from Saccharum officinarum L. juice: antinociceptive agents and molecular docking evaluations with µ-opioid receptor
Published in Natural product research (01-02-2023)“…Opioid receptors mediate antinociceptive effects. Methanolic fractions from sugarcane varieties (MFSCf) were evaluated in classic nociception models…”
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11
Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice
Published in Frontiers in pharmacology (17-10-2017)“…Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory…”
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12
Periodontal status, vascular reactivity, and platelet aggregation changes in rats submitted to hypercholesterolemic diet and periodontitis
Published in Journal of periodontal research (01-06-2020)“…Background and objectives Periodontitis can corroborate with development and progression of atherosclerosis and a possible bidirectional interaction between…”
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Antithrombotic potential of Lippia alba: A mechanistic approach
Published in Journal of ethnopharmacology (30-01-2023)“…Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson is traditionally used in Brazil as an adjunct in the relief of mild anxiety, as an antispasmodic, and as an…”
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Fish oil attenuates persistent inflammatory pain in rats through modulation of TNF-α and resolvins
Published in Life sciences (1973) (01-05-2016)“…Fish oil (FO), source of omega-3 fatty acids (FA), has been widely studied in the treatment of inflammatory diseases and inflammatory pain (IP). Omega-3 FA…”
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Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga)
Published in Phytomedicine (Stuttgart) (01-10-2009)“…Eugenia uniflora L. (Myrtaceae), known as Brazilian cherry tree, is a fruity tree spread all over Brazil used in popular medicine to treat inflammations,…”
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Prediction of Poor Outcomes for Septic Children According to Ferritin Levels in a Middle-Income Setting
Published in Pediatric critical care medicine (01-05-2020)“…To evaluate serum ferritin measured within 48 hours of admission as a prognostic marker and examine the association with unfavorable outcomes in a population…”
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Influence of Sex and Body Mass Index on the Thoracic Kyphosis and Lumbar Lordosis
Published in Journal of manipulative and physiological therapeutics (01-09-2022)“…The purpose of this study was to assess the influence of sex and body mass index (BMI) on the thoracic kyphosis and lumbar lordosis of adolescents and to…”
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Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies
Published in PloS one (14-03-2014)“…In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydrazone derivatives (1a-k) intended…”
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Discovery of novel orally active anti-inflammatory N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that inhibit TNF-α production
Published in PloS one (08-10-2012)“…Herein, we describe the synthesis and pharmacological evaluation of novel N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that were designed as novel…”
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LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain
Published in PloS one (18-06-2014)“…LASSBio-1135 is an imidazo[1,2-a]pyridine derivative with high efficacy in screening models of nociception and inflammation, presumed as a weak COX-2…”
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