Search Results - "Ana Mariño"

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel by Fernández-Mariño, Ana I., Harpole, Tyler J., Oelstrom, Kevin, Delemotte, Lucie, Chanda, Baron

“…Membrane potential regulates the activity of voltage-dependent ion channels via specialized voltage-sensing modules, but the mechanisms involved in coupling…”
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Dilation of ion selectivity filters in cation channels by Huffer, Kate, Tan, Xiao-Feng, Fernández-Mariño, Ana I., Dhingra, Surbhi, Swartz, Kenton J.

“…Dilated selectivity filters observed in inactivated voltage-activated K+ channel structures reveal that larger pores can result in reduced ion…”
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Inactivation of the Kv2.1 channel through electromechanical coupling by Fernández-Mariño, Ana I., Tan, Xiao-Feng, Bae, Chanhyung, Huffer, Kate, Jiang, Jiansen, Swartz, Kenton J.

“…The Kv2.1 voltage-activated potassium (Kv) channel is a prominent delayed-rectifier Kv channel in the mammalian central nervous system, where its mechanisms of…”
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Cryo-EM structure of the mammalian Kv2.1 channel and epileptic encephalopathy mutations provide insight into electromechanical coupling and slow inactivation by Fernández-Mariño, Ana I., Tan, Xiaofeng, Bae, Chanhyung, Swartz, Kenton J.

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Recommendations for modernizing infant vaccination schedules with combination vaccines in Colombia and Peru by Torres-Martinez, Carlos, Chaparro, Eduardo, Mariño, Ana-Cristina, Falleiros-Arlant, Luiza Helena, Camacho-Moreno, Germán, Castillo, María E, Garces, Carlos, Coronell, Wilfrido, Somocurcio, Roberto

“…The objective of this article was to consider the vaccination challenges in Colombia and Peru and the role of pediatric combination vaccines in overcoming…”
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Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers by Poveda, Eva, Fitzgerald, Wendy, Alonso-Domínguez, Jacobo, Aguayo-Arjona, José, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, Pérez, Alexandre, Ruiz-Mateos, Ezequiel, Margolis, Leonid, Lederman, Michael M, Freeman, Michael L

“…Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38…”
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Inactivation mechanism of an immunoglobulin modulator of the T-cell potassium channel Kv1.3 by Selvakumar, Purushotham, Fernández-Mariño, Ana I., Wang, Bing, Rice, William J., Meyerson, Joel R., Swartz, Kenton J.

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Massive Release of CD9+ Microvesicles in Human Immunodeficiency Virus Infection, Regardless of Virologic Control by Poveda, Eva, Tabernilla, Andrés, Fitzgerald, Wendy, Salgado-Barreira, Ángel, Grandal, Marta, Pérez, Alexandre, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, González-García, Juan, Bernardino, José Ignacio, Gutierrez, Félix, Fujioka, Hisashi, Crespo, Manuel, Ruiz-Mateos, Ezequiel, Margolis, Leonid, Lederman, Michael M, Freeman, Michael L

“…Abstract Background The role of extracellular vesicles (EVs) in human immunodeficiency virus (HIV) pathogenesis is unknown. We examine the cellular origin of…”
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Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1 by Poveda, Eva, Fitzgerald, Wendy, Reglero, Cristina, Pérez-González, Alexandre, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, Llibre, Josep Maria, Guillén, Santiago Moreno, Muñoz Fernández, Maria Angeles, Ruiz-Mateos, Ezequiel, Margolis, Leonid, Lederman, Michael M, Freeman, Michael L

“…Abstract Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including…”
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IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors by Álvarez, Hortensia, Gutiérrez-Valencia, Alicia, Mariño, Ana, Saborido-Alconchel, Abraham, Calderón-Cruz, Beatriz, Pérez-González, Alexandre, Alonso-Domínguez, Jacobo, Martínez-Barros, Inés, Gallego-Rodríguez, María, Moreno, Santiago, Aldamiz, Teresa, Montero-Alonso, Marta, Bernal, Enrique, Galera, Carlos, Llibre, Josep M., Poveda, Eva

“…BackgroundInterferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during…”
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Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse by Stix, Robyn, Tan, Xiao-Feng, Bae, Chanhyung, Fernández-Mariño, Ana I, Swartz, Kenton J, Faraldo-Gómez, José D

“…Eukaryotic voltage-gated K channels have been extensively studied, but the structural bases for some of their most salient functional features remain to be…”
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Structure of the Shaker Kv channel and mechanism of slow C-type inactivation by Tan, Xiao-Feng, Bae, Chanhyung, Stix, Robyn, Fernández-Mariño, Ana I, Huffer, Kate, Chang, Tsg-Hui, Jiang, Jiansen, Faraldo-Gómez, José D, Swartz, Kenton J

“…Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing…”
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Deprescribing of non-antiretroviral therapy in HIV-infected patients by Blanco, José-Ramón, Morillo, Ramón, Abril, Vicente, Escobar, Ismael, Bernal, Enrique, Folguera, Carlos, Brañas, Fátima, Gimeno, Mercedes, Ibarra, Olatz, Iribarren, José-Antonio, Lázaro, Alicia, Mariño, Ana, Martín, María-Teresa, Martinez, Esteban, Ortega, Luis, Olalla, Julian, Robustillo, Aguas, Sanchez-Conde, Matilde, Rodriguez, Miguel-Angel, de la Torre, Javier, Sanchez-Rubio, Javier, Tuset, Montse

“…Purpose In recent decades, the life expectancy of HIV-infected patients has increased considerably, to the extent that the disease can now be considered…”
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Phylogeny and Phylogeography of a Recent HIV-1 Subtype F Outbreak among Men Who Have Sex with Men in Spain Deriving from a Cluster with a Wide Geographic Circulation in Western Europe by Delgado, Elena, Cuevas, María Teresa, Domínguez, Francisco, Vega, Yolanda, Cabello, Marina, Fernández-García, Aurora, Pérez-Losada, Marcos, Castro, María Ángeles, Montero, Vanessa, Sánchez, Mónica, Mariño, Ana, Álvarez, Hortensia, Ordóñez, Patricia, Ocampo, Antonio, Miralles, Celia, Pérez-Castro, Sonia, López-Álvarez, María José, Rodríguez, Raúl, Trigo, Matilde, Diz-Arén, Julio, Hinojosa, Carmen, Bachiller, Pablo, Hernáez-Crespo, Silvia, Cisterna, Ramón, Garduño, Eugenio, Pérez-Álvarez, Lucía, Thomson, Michael M

“…We recently reported the rapid expansion of an HIV-1 subtype F cluster among men who have sex with men (MSM) in the region of Galicia, Northwest Spain. Here we…”
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Viruses Previously Identified in Brazil as Belonging to HIV-1 CRF72_BF1 Represent Two Closely Related Circulating Recombinant Forms, One of Which, Designated CRF122_BF1, Is Also Circulating in Spain by Cañada-García, Javier E, Delgado, Elena, Gil, Horacio, Benito, Sonia, Sánchez, Mónica, Ocampo, Antonio, Cabrera, Jorge Julio, Miralles, Celia, García-Bodas, Elena, Mariño, Ana, Ordóñez, Patricia, Gude, María José, Ezpeleta, Carmen, Thomson, Michael M

“…Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Those derived from recombination between subtype B and subsubtype F1, with…”
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Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes by Vega, Yolanda, Delgado, Elena, de la Barrera, Jorge, Carrera, Cristina, Zaballos, Ángel, Cuesta, Isabel, Mariño, Ana, Ocampo, Antonio, Miralles, Celia, Pérez-Castro, Sonia, Álvarez, Hortensia, López-Miragaya, Isabel, García-Bodas, Elena, Díez-Fuertes, Francisco, Thomson, Michael M

“…HIV-1 RNAs are generated through a complex splicing mechanism, resulting in a great diversity of transcripts, which are classified in three major categories:…”
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Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation by FERNANDEZ-MARINO, Ana I, PORRAS-GONZALEZ, Cristina, GONZALEZ-RODRIGUEZ, Patricia, SELENT, Jana, PASTOR, Manuel, URENA, Juan, CASTELLANO, Antonio, VALVERDE, Miguel A, FERNANDEZ-FERNANDEZ, Jose M

“…Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully…”
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Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies by Grandal, Marta, Pernas, Berta, Tabernilla, Andrés, Mariño, Ana, Álvarez, Hortensia, Valcarce, Nieves, Mena, Alvaro, Castro‐Iglesias, Angeles, Pérez, Ana B., Delgado, Manuel, Poveda, Eva

“…The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV…”
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Long-Term Carbapenems Antimicrobial Stewardship Program by García-Rodríguez, José Francisco, Bardán-García, Belén, Juiz-González, Pedro Miguel, Vilariño-Maneiro, Laura, Álvarez-Díaz, Hortensia, Mariño-Callejo, Ana

“…To evaluate clinical and antibiotic resistance impact of carbapenems stewardship programs. descriptive study, pre-post-intervention, between January 2012 and…”
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Characterization of chronic HCV infection in Northwest Spain: Impact of the treatment strategic plan of the Spanish National Health Service on HCV cure by Grandal, Marta, Pernas, Berta, Mariño, Ana, Álvarez, Hortensia, Tabernilla, Andrés, Castro‐Iglesias, Ángeles, Mena, Álvaro, Delgado, Manuel, Pértega, Sonia, Poveda, Eva

“…The aim of the study was to characterize HCV infection in Northwest Spain and assess the impact of the Spanish Strategic Plan to cure HCV infection. Overall,…”
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