Search Results - "Ana Maestre"

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors by Versteeg, Gijs A., Rajsbaum, Ricardo, Sánchez-Aparicio, Maria Teresa, Maestre, Ana M., Valdiviezo, Julio, Shi, Mude, Inn, Kyung-Soo, Fernandez-Sesma, Ana, Jung, Jae, García-Sastre, Adolfo

“…Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have…”
Get full text

DENV inhibits type I IFN production in infected cells by cleaving human STING by Aguirre, Sebastian, Maestre, Ana M, Pagni, Sarah, Patel, Jenish R, Savage, Timothy, Gutman, Delia, Maringer, Kevin, Bernal-Rubio, Dabeiba, Shabman, Reed S, Simon, Viviana, Rodriguez-Madoz, Juan R, Mulder, Lubbertus C F, Barber, Glen N, Fernandez-Sesma, Ana

“…Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a wide range of cells involved in the immune response. To efficiently…”
Get full text

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses by Tripathi, Shashank, Balasubramaniam, Vinod R M T, Brown, Julia A, Mena, Ignacio, Grant, Alesha, Bardina, Susana V, Maringer, Kevin, Schwarz, Megan C, Maestre, Ana M, Sourisseau, Marion, Albrecht, Randy A, Krammer, Florian, Evans, Matthew J, Fernandez-Sesma, Ana, Lim, Jean K, García-Sastre, Adolfo

“…Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas,…”
Get full text

Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling by Morrison, Juliet, Laurent-Rolle, Maudry, Maestre, Ana M, Rajsbaum, Ricardo, Pisanelli, Giuseppe, Simon, Viviana, Mulder, Lubbertus C F, Fernandez-Sesma, Ana, García-Sastre, Adolfo

“…An estimated 50 million dengue virus (DENV) infections occur annually and more than forty percent of the human population is currently at risk of developing…”
Get full text

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells by Filomatori, Claudia V, Carballeda, Juan M, Villordo, Sergio M, Aguirre, Sebastian, Pallarés, Horacio M, Maestre, Ana M, Sánchez-Vargas, Irma, Blair, Carol D, Fabri, Cintia, Morales, Maria A, Fernandez-Sesma, Ana, Gamarnik, Andrea V

“…The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a…”
Get full text

Antagonism of type I interferon by flaviviruses by Miorin, Lisa, Maestre, Ana M., Fernandez-Sesma, Ana, García-Sastre, Adolfo

“…The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a…”
Get full text

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response by Rajsbaum, Ricardo, Versteeg, Gijs A., Schmid, Sonja, Maestre, Ana M., Belicha-Villanueva, Alan, Martínez-Romero, Carles, Patel, Jenish R., Morrison, Juliet, Pisanelli, Giuseppe, Miorin, Lisa, Laurent-Rolle, Maudry, Moulton, Hong M., Stein, David A., Fernandez-Sesma, Ana, tenOever, Benjamin R., García-Sastre, Adolfo

“…Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of…”
Get full text

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency by Pache, Lars, Dutra, Miriam S., Spivak, Adam M., Marlett, John M., Murry, Jeffrey P., Hwang, Young, Maestre, Ana M., Manganaro, Lara, Vamos, Mitchell, Teriete, Peter, Martins, Laura J., König, Renate, Simon, Viviana, Bosque, Alberto, Fernandez-Sesma, Ana, Cosford, Nicholas D.P., Bushman, Frederic D., Young, John A.T., Planelles, Vicente, Chanda, Sumit K.

“…Combination antiretroviral therapy (ART) is able to suppress HIV-1 replication to undetectable levels. However, the persistence of latent viral reservoirs…”
Get full text

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection by Aguirre, Sebastian, Luthra, Priya, Sanchez-Aparicio, Maria T., Maestre, Ana M., Patel, Jenish, Lamothe, Francise, Fredericks, Anthony C., Tripathi, Shashank, Zhu, Tongtong, Pintado-Silva, Jessica, Webb, Laurence G., Bernal-Rubio, Dabeiba, Solovyov, Alexander, Greenbaum, Benjamin, Simon, Viviana, Basler, Christopher F., Mulder, Lubbertus C. F., García-Sastre, Adolfo, Fernandez-Sesma, Ana

“…During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To…”
Get full text

The infectious bursal disease virus RNA-binding VP3 polypeptide inhibits PKR-mediated apoptosis by Busnadiego, Idoia, Maestre, Ana M, Rodríguez, Dolores, Rodríguez, José F

“…Infectious bursal disease virus (IBDV) is an avian pathogen responsible for an acute immunosuppressive disease that causes major losses to the poultry…”
Get full text

HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3 by Manganaro, Lara, de Castro, Elisa, Maestre, Ana M, Olivieri, Kevin, García-Sastre, Adolfo, Fernandez-Sesma, Ana, Simon, Viviana

“…The accessory HIV protein Vpu inhibits a number of cellular pathways that trigger host innate restriction mechanisms. HIV Vpu-mediated degradation of tetherin…”
Get full text

Assessment of Spanish Food Consumption Patterns during COVID-19 Home Confinement by Maestre, Ana, Sospedra, Isabel, Martínez-Sanz, José Miguel, Gutierrez-Hervas, Ana, Fernández-Saez, José, Hurtado-Sánchez, José Antonio, Norte, Aurora

“…People’s eating habits and lifestyle can have a negative impact on health. In situations of difficulty or socioeconomic crisis, these habits tend to be…”
Get full text

Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis by Miller, Matthew S, Rialdi, Alexander, Ho, Jessica Sook Yuin, Tilove, Micah, Martinez-Gil, Luis, Moshkina, Natasha P, Peralta, Zuleyma, Noel, Justine, Melegari, Camilla, Maestre, Ana M, Mitsopoulos, Panagiotis, Madrenas, Joaquín, Heinz, Sven, Benner, Chris, Young, John A T, Feagins, Alicia R, Basler, Christopher F, Fernandez-Sesma, Ana, Becherel, Olivier J, Lavin, Martin F, van Bakel, Harm, Marazzi, Ivan

“…Mutations in the gene encoding the helicase senataxin have well established associations with the neurodegenerative disease ALS. Marazzi et al . show that…”
Get full text

Equine torovirus (BEV) induces caspase-mediated apoptosis in infected cells by Maestre, Ana M, Garzón, Ana, Rodríguez, Dolores

“…Toroviruses are gastroenteritis causing agents that infect different animal species and humans. To date, very little is known about how toroviruses cause…”
Get full text

Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses by Chiang, Chih-yuan, Engel, Alex, Opaluch, Amanda M., Ramos, Irene, Maestre, Ana M., Secundino, Ismael, De Jesus, Paul D., Nguyen, Quy T., Welch, Genevieve, Bonamy, Ghislain M.C., Miraglia, Loren J., Orth, Anthony P., Nizet, Victor, Fernandez-Sesma, Ana, Zhou, Yingyao, Barton, Gregory M., Chanda, Sumit K.

“…Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded…”
Get full text

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ by Opaluch, Amanda M, Schneider, Monika, Chiang, Chih-yuan, Nguyen, Quy T, Maestre, Ana M, Mulder, Lubbertus C F, Secundino, Ismael, De Jesus, Paul D, König, Renate, Simon, Viviana, Nizet, Victor, MacLeod, Graham, Varmuza, Susannah, Fernandez-Sesma, Ana, Chanda, Sumit K

“…Innate immune sensors such as Toll-like receptors (TLRs) differentially utilize adaptor proteins and additional molecular mediators to ensure robust and…”
Get full text

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection by Aguirre, Sebastian, Luthra, Priya, Sanchez-Aparicio, Maria T., Maestre, Ana M., Patel, Jenish, Lamothe, Francise, Fredericks, Anthony C., Tripathi, Shashank, Zhu, Tongtong, Pintado-Silva, Jessica, Webb, Laurence G., Bernal-Rubio, Dabeiba, Solovyov, Alexander, Greenbaum, Benjamin, Simon, Viviana, Basler, Christopher F., Mulder, Lubbertus C. F., García-Sastre, Adolfo, Fernandez-Sesma, Ana

Get full text

ZIKV Strains' Different Phenotypes in Human Neural Cells Could be a Hint for the Emergence of the New Clinical Neurological Outcomes by Maestre, Ana M., Fernandez-Sesma, Ana

Get full text

Finding Clues for Congenital Zika Syndrome: Zika Virus Selective Infection of Immature Neurons by Maestre, Ana M., Fernández-Sesma, Ana

Get full text

Effect of a sustained-release formulation of β-alanine on laboratory parameters and paresthesia in recreational trained men: a randomized double-blind placebo-controlled study by Maestre-Hernández, Ana Belén, Pérez-Piñero, Silvia, López-Román, Francisco Javier, Andreu-Caravaca, Luis, Luque-Rubia, Antonio J., Ramos-Campo, Domingo J., Díaz-Silvestre, María José, Ávila-Gandía, Vicente

“…Introduction Beta-alanine is a non-essential amino acid that has been a focus of increasing research by its role as ergogenic aid to improve muscle…”
Get full text