Search Results - "Ana Lacalle, Rosa"

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α by Mira, Emilia, Carmona-Rodríguez, Lorena, Pérez-Villamil, Beatriz, Casas, Josefina, Fernández-Aceñero, María Jesús, Martínez-Rey, Diego, Martín-González, Paula, Heras-Murillo, Ignacio, Paz-Cabezas, Mateo, Tardáguila, Manuel, Oury, Tim D., Martín-Puig, Silvia, Lacalle, Rosa Ana, Fabriás, Gemma, Díaz-Rubio, Eduardo, Mañes, Santos

“…One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide…”
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Filamin-A regulates actin-dependent clustering of HIV receptors by Viola, Antonella, Gómez-Moutón, Concepción, Martínez-Prats, Lorena, Ana Lacalle, Rosa, Jiménez-Baranda, Sonia, Martínez-A, Carlos, Mañes, Santos, Dimitrov, Dimiter S, Delgado, Rafael, Rojas, Ana, Mira, Emilia, Valencia, Alfonso

“…Human immunodeficiency virus (HIV)-1 infection requires envelope (Env) glycoprotein gp120-induced clustering of CD4 and coreceptors (CCR5 or CXCR4) on the cell…”
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Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement by Lacalle, Rosa Ana, Peregil, Rosa M, Albar, Juan Pablo, Merino, Ernesto, Martínez-A, Carlos, Mérida, Isabel, Mañes, Santos

“…Directional cell movement in response to external chemical gradients requires establishment of front-rear asymmetry, which distinguishes an up-gradient…”
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Membrane raft microdomains mediate front-rear polarity in migrating cells by Mañes, Santos, Mira, Emilia, Gómez-Moutón, Concepción, Ana Lacalle, Rosa, Keller, Patrick, Pablo Labrador, Juan, Martínez-A, Carlos

“…The acquisition of spatial and functional asymmetry between the rear and the front of the cell is a necessary step for cell chemotaxis. Insulin‐like growth…”
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From rafts to crafts: membrane asymmetry in moving cells by Mañes, Santos, Ana Lacalle, Rosa, Gómez-Moutón, Concepción, Martı́nez-A, Carlos

“…Many important biological events, including the leukocyte-mediated immune response, wound repair, axon guidance and developmental patterning, involve…”
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PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8 + T lymphocytes by Ogando, Jesús, Sáez, María Eugenia, Santos, Javier, Nuevo-Tapioles, Cristina, Gut, Marta, Esteve-Codina, Anna, Heath, Simon, González-Pérez, Antonio, Cuezva, José M, Lacalle, Rosa Ana, Mañes, Santos

“…Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade…”
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Orchestration of lymphocyte chemotaxis by mitochondrial dynamics by Campello, Silvia, Lacalle, Rosa Ana, Bettella, Monica, Mañes, Santos, Scorrano, Luca, Viola, Antonella

“…Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must…”
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A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity by Santos, Javier, Ogando, Jesús, Lacalle, Rosa Ana, Mañes, Santos

“…Cancer immunotherapy relies on the ability of immune cells to kill malignant cells. The cytotoxic T lymphocyte (CTL) response is perhaps the functional measure…”
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Type I phosphatidylinositol 4‐phosphate 5‐kinase homo‐ and heterodimerization determines its membrane localization and activity by Lacalle, Rosa Ana, Karam, Juan C., Martínez‐Muñoz, Laura, Artetxe, Ibai, Peregil, Rosa M., Sot, Jesús, Rojas, Ana M., Goñi, Félix M., Mellado, Mario, Mañes, Santos

“…ABSTRACT Type I phosphatidylinositol 4‐phosphate 5‐kinases (PIP5KIs; α, β, and γ) are a family of isoenzymes that produce phosphatidylinositol 4,…”
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Statins inhibit HIV-1 infection by down-regulating Rho activity by del Real, Gustavo, Jiménez-Baranda, Sonia, Mira, Emilia, Lacalle, Rosa Ana, Lucas, Pilar, Gómez-Moutón, Concepción, Alegret, Marta, Peña, Jose María, Rodríguez-Zapata, Manuel, Alvarez-Mon, Melchor, Martínez-A, Carlos, Mañes, Santos

“…Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft-associated receptors, a process that might be linked to…”
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Segregation of Leading-Edge and Uropod Components into Specific Lipid Rafts during T Cell Polarization by Gómez-Moutón, Concepción, Abad, Jose Luis, Mira, Emilia, Lacalle, Rosa Ana, Gallardo, Eduard, Jiménez-Baranda, Sonia, Illa, Isabel, Bernad, Antonio, Mañes, Santos, Carlos Martinez-A.

“…Redistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that…”
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Dynamic Redistribution of Raft Domains as an Organizing Platform for Signaling during Cell Chemotaxis by Gómez-Moutón, Concepción, Lacalle, Rosa Ana, Mira, Emilia, Jiménez-Baranda, Sonia, Barber, Domingo F., Carrera, Ana C., Carlos Martínez-A, Mañes, Santos

“…Spatially restricted activation of signaling molecules governs critical aspects of cell migration; the mechanism by which this is achieved nonetheless remains…”
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isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells by Mañes, Santos, Fuentes, Gloria, Peregil, Rosa M, Rojas, Ana M, Lacalle, Rosa Ana

“…Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI)-β participates in establishing polarity during leukocyte chemotaxis. Its final 83 amino acids…”
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Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface by Mira, Emilia, Lacalle, Rosa Ana, Buesa, José María, de Buitrago, Gonzalo González, Jiménez-Baranda, Sonia, Gómez-Moutón, Concepción, Martínez-A, Carlos, Mañes, Santos

“…Association of matrix metalloprotease 9 (MMP9) to the cell membrane is considered important in tumor growth and angiogenesis. To dissect this regulatory…”
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Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection by Mañes, Santos, del Real, Gustavo, Lacalle, Rosa Ana, Lucas, Pilar, Gómez-Moutón, Concepción, Sánchez-Palomino, Sonsoles, Delgado, Rafael, Alcamí, José, Mira, Emilia, Martínez-A, Carlos

“…HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope with cell surface receptors. We show that these membrane…”
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CCR5 expression influences the progression of human breast cancer in a p53-dependent manner by Mañes, Santos, Mira, Emilia, Colomer, Ramón, Montero, Sagrario, Real, Luis M, Gómez-Moutón, Concepción, Jiménez-Baranda, Sonia, Garzón, Alfredo, Lacalle, Rosa Ana, Harshman, Keith, Ruíz, Agustín, Martínez-A, Carlos

“…Chemokines are implicated in tumor pathogenesis, although it is unclear whether they affect human cancer progression positively or negatively. We found that…”
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Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility by Mañes, Santos, Mira, Emilia, Gómez-Mouton, Concepción, Zhao, Zhizuang Joe, Lacalle, Rosa Ana, Martínez-A., Carlos

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains by Del Real, Gustavo, Jiménez-Baranda, Sonia, Lacalle, Rosa Ana, Mira, Emilia, Lucas, Pilar, Gómez-Moutón, Concepción, Carrera, Ana C, Martínez-A, Carlos, Mañes, Santos

“…Human immunodeficiency virus (HIV)-1 infection depends on multiple lateral interactions between the viral envelope and host cell receptors. Previous studies…”
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The Matrix Metalloproteinase-9 Regulates the Insulin-like Growth Factor-triggered Autocrine Response in DU-145 Carcinoma Cells by Mañes, Santos, Llorente, Mercedes, Lacalle, Rosa Ana, Gómez-Moutón, Concepción, Kremer, Leonor, Mira, Emilia, Martı́nez-A, Carlos

“…The androgen-independent human prostate adenocarcinoma cell line DU-145 proliferates in serum-free medium and produces insulin-like growth factors (IGF)-I,…”
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Specific SHP-2 Partitioning in Raft Domains Triggers Integrin-Mediated Signaling via Rho Activation by Lacalle, Rosa Ana, Mira, Emilia, Gomez-Mouton, Concepcion, Jimenez-Baranda, Sonia, Martinez-A, Carlos, Manes, Santos

“…Cell signaling does not occur randomly over the cell surface, but is integrated within cholesterol-enriched membrane domains, termed rafts. By targeting SHP-2…”
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