Changes in serum antimüllerian hormone levels in patients 6 and 12 months after endometrioma stripping surgery

Changes in serum antimüllerian hormone levels in patients 6 and 12 months after endometrioma stripping surgery

To investigate the impact of laparoscopic endometrioma cystectomy on the ovarian reserve and to identify the most important factors that predict the ovarian reserve in patients with endometriomas. Prospective study. Endoscopy unit of a general hospital. Fifty-four patients with unilateral (n = 37) a...

Full description

Saved in:
Bibliographic Details
Published in:Fertility and sterility Vol. 110; no. 6; pp. 1173 - 1180
Main Authors: Kovačević, Vera Miodrag, Anđelić, Luka Momir, Mitrović Jovanović, Ana
Format: Journal Article
Language:English
Published: United States 01-11-2018
Subjects:
antimüllerian hormone
laparoscopy
ovarian reserve
Endometrioma
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the impact of laparoscopic endometrioma cystectomy on the ovarian reserve and to identify the most important factors that predict the ovarian reserve in patients with endometriomas. Prospective study. Endoscopy unit of a general hospital. Fifty-four patients with unilateral (n = 37) and bilateral endometriomas (n = 17). The serum antimüllerian hormone (AMH) concentration was assessed before surgery and at 6 and 12 months after surgery. The primary outcome was the damage to the ovarian reserve, as assessed by the serum AMH concentration. Secondary end points were the persistence or recovery of ovarian damage after 1 year. AMH concentrations decreased after the laparoscopic excision of cystic ovarian endometriomas. Before surgery and at 6 and 12 months after surgery, the concentrations were, respectively 3.07, 1.29, and 1.46 ng/mL. In the unilateral group, the median AMH levels were 3.31, 1.43, and 1.72 ng/mL, and in the bilateral group the levels were 2.55, 0.98, and 0.89 ng/mL. The serum AMH concentrations thus decreased by 53.27 ± 38.2% and 49.43 ± 38.3% at 6 and 12 months after cystectomy, respectively. In patients with endometriomas, the decrease in ovarian reserve occurs immediately after the excision of the endometrioma. Significant predictors of AMH values at 6 and 12 months after surgery include the baseline AMH level, patient age, and bilateral endometriomas.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2018.07.019