Search Results - "An, Woojin"

Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis by Shin, Yonghwan, Kim, Sungmin, An, Woojin

“…Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the metastatic…”
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MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis by Shin, Yonghwan, Kim, Sungmin, Liang, Gangning, An, Woojin

“…Matrix metalloproteinase 9 (MMP‐9) is a member of the MMP family and has been recently identified as a nuclear protease capable of clipping histone H3…”
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MMP-9 drives the melanomagenic transcription program through histone H3 tail proteolysis by Shin, Yonghwan, Kim, Sungmin, Ghate, Nikhil B., Rhie, Suhn K., An, Woojin

“…Melanoma is a type of skin cancer that develops in pigment-producing melanocytes and often spreads to other parts of the body. Aberrant gene expression has…”
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MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis by Kim, Kyunghwan, Punj, Vasu, Kim, Jin-Man, Lee, Sunyoung, Ulmer, Tobias S, Lu, Wange, Rice, Judd C, An, Woojin

“…Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites…”
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Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53 by An, Woojin, Kim, Jaehoon, Roeder, Robert G

“…Transcriptional coactivators that modify histones represent an increasingly important group of regulatory factors, although their ability to modify other…”
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Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells by Kim, Jin-Man, Kim, Kyunghwan, Schmidt, Thomas, Punj, Vasu, Tucker, Haley, Rice, Judd C, Ulmer, Tobias S, An, Woojin

“…SET and MYND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in cell growth and cancer pathogenesis. Increasing…”
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Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer by Ghate, Nikhil B., Kim, Sungmin, Shin, Yonghwan, Kim, Jinman, Doche, Michael, Valena, Scott, Situ, Alan, Kim, Sangnam, Rhie, Suhn K., Lenz, Heinz-Josef, Ulmer, Tobias S., Mumenthaler, Shannon M., An, Woojin

“…Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene…”
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Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3 by Kim, Jin-Man, Kim, Kyunghwan, Punj, Vasu, Liang, Gangning, Ulmer, Tobias S., Lu, Wange, An, Woojin

“…Linker histone H1 is a protein component of chromatin and has been linked to higher-order chromatin compaction and global gene silencing. However, a growing…”
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VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer by Ghate, Nikhil Baban, Kim, Sangnam, Spiller, Erin, Kim, Sungmin, Shin, Yonghwan, Rhie, Suhn K., Smbatyan, Goar, Lenz, Heinz‐Josef, Mumenthaler, Shannon M., An, Woojin

“…Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase,…”
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FACT-Mediated Exchange of Histone Variant H2AX Regulated by Phosphorylation of H2AX and ADP-Ribosylation of Spt16 by Heo, Kyu, Kim, Hyunjung, Choi, Si Ho, Choi, Jongkyu, Kim, Kyunghwan, Gu, Jiafeng, Lieber, Michael R., Yang, Allen S., An, Woojin

“…The phosphorylation of histone variant H2AX at DNA double-strand breaks is believed to be critical for recognition and repair of DNA damage. However, little is…”
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Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription by Kim, Hyunjung, Heo, Kyu, Kim, Jeong Hoon, Kim, Kyunghwan, Choi, Jongkyu, An, Woojin

“…SMYD3 is a SET domain-containing protein with histone methyltransferase activity on histone H3–K4. Recent studies showed that SMYD3 is frequently overexpressed…”
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H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis by Kim, Kyunghwan, Shin, Yonghwan, Kim, Jinman, Ulmer, Tobias S, An, Woojin

“…MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture…”
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Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3 by Kim, Jinman, Shin, Yonghwan, Lee, Sunyoung, Kim, Miyeong, Punj, Vasu, Lu, Jason F., Shin, Hongin, Kim, Kyunghwan, Ulmer, Tobias S., Koh, Jungmin, Jeong, Daewon, An, Woojin

“…Breast cancer cells relocate to bone and activate osteoclast-induced bone resorption. Soluble factors secreted by breast cancer cells trigger a cascade of…”
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p32 is a negative regulator of p53 tetramerization and transactivation by Ghate, Nikhil Baban, Kim, Jinman, Shin, Yonghwan, Situ, Alan, Ulmer, Tobias S., An, Woojin

“…p53 is a sequence‐specific transcription factor, and proper regulation of p53 transcriptional activity is critical for orchestrating different…”
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CCAR1, a Key Regulator of Mediator Complex Recruitment to Nuclear Receptor Transcription Complexes by Kim, Jeong Hoon, Yang, Catherine K., Heo, Kyu, Roeder, Robert G., An, Woojin, Stallcup, Michael R.

“…DNA-bound transcription factors recruit many coactivator proteins to remodel chromatin and activate transcription. The Mediator complex is believed to recruit…”
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VprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation by Shin, Yonghwan, Kim, Sungmin, Liang, Gangning, Ulmer, Tobias S, An, Woojin

“…Vpr binding protein (VprBP), also known as DDB1- and CUL4-associated factor1 (DCAF1), is a recently identified atypical kinase and plays an important role in…”
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Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing by Zhang, Zhuo, Jones, Amanda E., Wu, Wei, Kim, Jinman, Kang, Yue, Bi, Xiaobao, Gu, Yue, Popov, Ivan K., Renfrow, Matthew B., Vassylyeva, Marina N., Vassylyev, Dmitry G., Giles, Keith E., Chen, Dongquan, Kumar, Ashwath, Fan, Yuhong, Tong, Yufeng, Liu, Chuan-Fa, An, Woojin, Chang, Chenbei, Luo, Jianjun, Chow, Louise T., Wang, Hengbin

“…Posttranslational histone modifications play important roles in regulating chromatin-based nuclear processes. Histone H2AK119 ubiquitination (H2Aub) is a…”
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The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells by Gao, Fan, Wei, Zong, An, Woojin, Wang, Kai, Lu, Wange

“…The genes POU5F1 and SOX2 are critical for pluripotency and reprogramming, yet the chromosomal organization around these genes remains poorly understood. We…”
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VprBP Has Intrinsic Kinase Activity Targeting Histone H2A and Represses Gene Transcription by Kim, Kyunghwan, Kim, Jin-Man, Kim, Joong-Sun, Choi, Jongkyu, Lee, Yong Suk, Neamati, Nouri, Song, Jin Sook, Heo, Kyu, An, Woojin

“…Histone modifications play important roles in the regulation of gene expression and chromatin organization. VprBP has been implicated in transcriptionally…”
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Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail by Kim, Kyunghwan, Heo, Kyu, Choi, Jongkyu, Jackson, Sarah, Kim, Hyunjung, Xiong, Yue, An, Woojin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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