Search Results - "An, Elroy H."

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival by Ramos, Fresnida J, Chen, Steven C, Garelick, Michael G, Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H, MacKay, Vivian L, An, Elroy H, Strong, Randy, Ladiges, Warren C, Rabinovitch, Peter S, Kaeberlein, Matt, Kennedy, Brian K

“…Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including dystrophies of the skeletal muscle and fat, dilated cardiomyopathy,…”
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Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging by Delaney, Joe R., Ahmed, Umema, Chou, Annie, Sim, Sylvia, Carr, Daniel, Murakami, Christopher J., Schleit, Jennifer, Sutphin, George L., An, Elroy H., Castanza, Anthony, Fletcher, Marissa, Higgins, Sean, Jelic, Monika, Klum, Shannon, Muller, Brian, Peng, Zhao J., Rai, Dilreet, Ros, Vanessa, Singh, Minnie, Wende, Helen V., Kennedy, Brian K., Kaeberlein, Matt

“…Summary Although environmental stress likely plays a significant role in promoting aging, the relationship remains poorly understood. To characterize this…”
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pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast by Murakami, Christopher, Delaney, Joe R., Chou, Annie, Carr, Daniel, Schleit, Jennifer, Sutphin, George L., An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Vander Wende, Helen, Wang, Adrienne M., Wasko, Brian M., Olsen, Brady, Kaeberlein, Matt

“…Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for…”
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Sir2 deletion prevents lifespan extension in 32 long‐lived mutants by Delaney, Joe R., Sutphin, George L., Dulken, Ben, Sim, Sylvia, Kim, Jin R., Robison, Brett, Schleit, Jennifer, Murakami, Christopher J., Carr, Daniel, An, Elroy H., Choi, Eunice, Chou, Annie, Fletcher, Marissa, Jelic, Monika, Liu, Bin, Lockshon, Daniel, Moller, Richard M., Pak, Diana N., Peng, Qi, Peng, Zhao J., Pham, Kim M., Sage, Michael, Solanky, Amrita, Steffen, Kristan K., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Johnson, Simon, Raabe, Chris, Suh, Yousin, Zhou, Zhongjun, Liu, Xinguang, Kennedy, Brian K., Kaeberlein, Matt

“…Summary Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32…”
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Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae by Delaney, Joe R., Murakami, Christopher, Chou, Annie, Carr, Daniel, Schleit, Jennifer, Sutphin, George L., An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Wende, Helen Vander, Wang, Adrienne M., Wasko, Brian M., Olsen, Brady, Kaeberlein, Matt

“…Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary…”
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End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging by Delaney, Joe R., Chou, Annie, Olsen, Brady, Carr, Daniel, Murakami, Christopher, Ahmed, Umema, Sim, Sylvia, An, Elroy H., Castanza, Anthony S., Fletcher, Marissa, Higgins, Sean, Holmberg, Mollie, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Moller, Richard, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Schleit, Jennifer, Schuster, Alex, Singh, Minnie, Spector, Benjamin L., Sutphin, George L., Wang, Adrienne M., Wasko, Brian M., Vander Wende, Helen, Kennedy, Brian K., Kaeberlein, Matt

“…Abstract There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have…”
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Molecular mechanisms underlying genotype‐dependent responses to dietary restriction by Schleit, Jennifer, Johnson, Simon C., Bennett, Christopher F., Simko, Marissa, Trongtham, Natalie, Castanza, Anthony, Hsieh, Edward J., Moller, Richard M., Wasko, Brian M., Delaney, Joe R., Sutphin, George L., Carr, Daniel, Murakami, Christopher J., Tocchi, Autumn, Xian, Bo, Chen, Weiyang, Yu, Tao, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Jeong, Ki‐Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Olsen, Brady, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Singh, Minnie, Spector, Benjamin L., Wende, Helen Vander, An, Elroy H., Fletcher, Marissa, Jelic, Monika, Rabinovitch, Peter S., MacCoss, Michael J., Han, Jing‐Dong J., Kennedy, Brian K., Kaeberlein, Matt

“…Summary Dietary restriction (DR) increases lifespan and attenuates age‐related phenotypes in many organisms; however, the effect of DR on longevity of…”
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