Effectiveness of community-based DOTS strategy on tuberculosis treatment success rates in Namibia

SETTING: DOTS is a key pillar of the global strategy to end tuberculosis (TB).OBJECTIVE: To assess the effectiveness of community-based compared with facility-based DOTS on TB treatment success rates in Namibia.METHODS: Annual TB treatment success, cure, completion and case notification rates were c...

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Bibliographic Details
Published in:	The international journal of tuberculosis and lung disease Vol. 23; no. 4; pp. 441 - 449
Main Authors:	Kibuule, D., Rennie, T. W., Ruswa, N., Mavhunga, F., Thomas, A., Amutenya, R., Law, M. R., Günther, G., Ette, E., Godman, B., Verbeeck, R. K.
Format:	Journal Article
Language:	English
Published:	France International Union Against Tuberculosis and Lung Disease 01-04-2019 International Union against Tuberculosis and Lung Disease (IUATLD)
Subjects:	Antitubercular Agents - administration & dosage Communities Community Health Services - methods Directly Observed Therapy - methods Humans Interferon Intervention Medicin och hälsovetenskap Namibia Policy Analysis Population-Based Strategy Success Tb Treatment Outcome Time series Treatment Outcome Tuberculosis Tuberculosis - drug therapy Namibia
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Summary:	SETTING: DOTS is a key pillar of the global strategy to end tuberculosis (TB).OBJECTIVE: To assess the effectiveness of community-based compared with facility-based DOTS on TB treatment success rates in Namibia.METHODS: Annual TB treatment success, cure, completion and case notification rates were compared between 1996 and 2015 using interrupted time series analysis. The intervention was the upgrading by the Namibian government of the TB treatment strategy from facility-based to community-based DOTS in 2005.RESULTS: The mean annual treatment success rate during the pre-intervention period was 58.9% (range 46-66) and increased significantly to 81.3% (range 69-87) during the post-intervention period. Before the intervention, there was a non-significant increase (0.3%/year) in the annual treatment success rate. After the intervention, the annual treatment success rate increased abruptly by 12.9% (P < 0.001) and continued to increase by 1.1%/year thereafter. The treatment success rate seemed to have stagnated at ∼85% at the end of the observation period.CONCLUSION: Expanding facility-based DOTS to community-based DOTS increased annual treatment success rates significantly. However, the treatment success rate at the end of the observation period had stagnated below the targeted 95% success rate.
Bibliography:	(R) Medicine - General 1027-3719(20190401)23:4L.441;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1027-3719 1815-7920 1815-7920
DOI:	10.5588/ijtld.17.0785