Search Results - "Amthor, H"

The basic concept of therapeutic approaches for DMD by Amthor, H

“…Duchenne muscular dystrophy (DMD) is the most frequent hereditary neuromuscular disorder in childhood. Over the past 30 years, increasingly better standards of…”
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BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells by Ono, Y, Calhabeu, F, Morgan, J E, Katagiri, T, Amthor, H, Zammit, P S

“…Satellite cells are the resident stem cells of adult skeletal muscle, supplying myonuclei for homoeostasis, hypertrophy and repair. In this study, we have…”
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Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse plantaris muscle by Stantzou, A., Relizani, K., Morales‐Gonzalez, S., Gallen, C., Grassin, A., Ferry, A., Schuelke, M., Amthor, H.

“…Overload induced muscle dystrophy causes extracellular matrix remodelling as seen by upregulation of genes associated with the gene ontology (GO)‐terms…”
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Live-imaging of revertant and therapeutically restored dystrophin in the Dmd EGFP-mdx mouse model for Duchenne muscular dystrophy by Petkova, M V, Stantzou, A, Morin, A, Petrova, O, Morales-Gonzalez, S, Seifert, F, Bellec-Dyevre, J, Manoliu, T, Goyenvalle, A, Garcia, L, Richard, I, Laplace-Builhé, C, Schuelke, M, Amthor, H

“…Dmd , harbouring the c.2983C>T nonsense mutation in Dmd exon 23, is a mouse model for Duchenne muscular dystrophy (DMD), frequently used to test therapies…”
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Live‐imaging of revertant and therapeutically restored dystrophin in the DmdEGFP‐mdx mouse model for Duchenne muscular dystrophy by Petkova, M. V., Stantzou, A., Morin, A., Petrova, O., Morales‐Gonzalez, S., Seifert, F., Bellec‐Dyevre, J., Manoliu, T., Goyenvalle, A., Garcia, L., Richard, I., Laplace‐Builhé, C., Schuelke, M., Amthor, H.

“…Background Dmdmdx, harbouring the c.2983C>T nonsense mutation in Dmd exon 23, is a mouse model for Duchenne muscular dystrophy (DMD), frequently used to test…”
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The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age by Schirwis, E., Agbulut, O., Vadrot, Nathalie, Mouisel, E., Hourdé, C., Bonnieu, A., Butler-Browne, G., Amthor, H., Ferry, A.

“…The prolonged effect of myostatin deficiency on muscle performance in knockout mice has as yet been only poorly investigated. We have demonstrated that…”
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A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation by Amthor, H, Christ, B, Patel, K

“…Embryonic muscle growth requires a fine balance between proliferation and differentiation. In this study we have investigated how this balance is achieved…”
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STAC3 p.Trp284Ser associated with congenital myopathy with distinctive dysmorphic features and malignant hyperthermia by Zaharieva, I, Sarkozy, A, Manzur, A, Munot, P, O’Grady, G, Rendu, J, Amthor, H, Servais, L, Malfatti, E, Dixon, J, Poke, G, Donkervoort, S, Foley, A.R, Neto, O.L.A, Davis, M.R, Urtizberea, J.A, Bastaki, L, Romero, N.B, Oates, E.C, Holmes, C, Williams, G, Sframeli, M, Yum, S, Medne, L, Roy, S.Q, Fauré, J, Feng, L, Morgan, J.E, Bönnemann, C.G, Phadke, R, Sewry, C.A, Treves, S, Muntoni, F

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G.P.195 by Beley, C, Schirwis, E, Mouisel, E, Alonso-Martin, S, Rochat, A, Garcia, L, Ferry, A, Relaix, F, Schuelke, M, Le Grand, F, Amthor, H

“…Postnatal/juvenil muscle growth is achieved by both an increase in myofiber size and the addition of further myonuclei, whereas myofiber number does not…”
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O.20 BMP signalling controls muscle mass by Amthor, H, Sartori, R, Schirwis, E, Blaauw, B, Bortolanza, S, Zhao, J, Enzo, E, Stantzou, A, Mouisel, E, Toniolo, L, Ferry, A, Stricker, S, Goldberg, A.L, Dupont, S, Piccolo, S, Sandri, M

“…Cell size is determined by the balance between protein synthesis and degradation. This equilibrium is affected by hormones, nutrients, energy levels,…”
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T.O.7 Blockade of Myostatin/ActRIIB signalling induces skeletal muscle fatigability and exercise intolerance by Relizani, K, Mouisel, E, Fortin, D, Vignaud, A, Garcia, L, Ventura-Clapier, R, Schuelke, M, Amthor, H

“…Abstract Blockade of myostatin/ActRIIB signaling has been proposed as a therapeutic strategy for Duchenne muscular dystrophy (DMD) because of its supposed…”
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P4.23 The role of activin receptor IIB signalling on skeletal muscle and the possible therapeutic implication for Duchenne muscular dystrophy by Mouisel, E, Barthélémy, I, Ferry, A, Garcia, L, Blot, S, Amthor, H

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O.10 Effect of combined treatment with soluble activin receptor IIB and AAV-U7-mediated dystrophin exon skipping on muscle function in mdx mice by Hoogaars, W.M.H, Mouisel, E, Relizani, K, Pasternack, A, Hourde, C, Precigout, G, Ferry, A, Garcia, L, Kemaladewi, D.U, Aartsma-Rus, A, Ritvos, O, t Hoen, P.A.C, Amthor, H

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P3.25 Satellite cell dependent growth and regeneration of skeletal muscle requires BMP signalling by Amthor, H, Relaix, F, Mouisel, E, Rochat, A, Beley, C, Hourdé, C, Schirwis, E, Alonso-Martin, S

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Bone Morphogenetic Protein-2 (BMP-2) Inhibits Muscle Development and Promotes Cartilage Formation in Chick Limb Bud Cultures by Duprez, D.M., Coltey, M., Amthor, H., Brickell, P.M., Tickle, C.

“…Bone morphogenetic proteins (BMPs) induce ectopic cartilage and bone when implanted intramuscularly in adult rats. Expression data suggest that BMPs signal…”
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P3.17 Lack of myostatin impairs oxidative metabolism and exercise performance by Mouisel, E, Giannesini, B, Mille-Hamard, L, Vignaud, A, Denis, R, Hourde, C, Garcia, L, Ferry, A, Luquet, S, Billat, V, Bendahan, D, Ventura-Clapier, R, Amthor, H

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G.P.3.14 No evidence for increased muscle regeneration in myostatin deficient mdx mice ( mstn -/- mdx ) by Amthor, H, Friedrichs, M, Voit, T

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G.P.8.07 Increased oxidative metabolism in mdx muscle treated by a combination of exon skipping and myostatin blockade by Hourdé, C, Marie, S, Mouisel, E, Garcia, L, Dumonceaux, J, Amthor, H

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G.P.7.04 Mosaic of an ACTA1 mutation in a child with nemaline myopathy and cardiomyopathy by Amthor, H, Quijano-Roy, S, Drouhin, S, Claeys, K.G, Bataille, J, Estournet, B, Romero, N.B, Monnier, N, Lunardi, J

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Molecular mechanisms involving IGF-1 and myostatin to induce muscle hypertrophy as a therapeutic strategy for Duchenne muscular dystrophy by Patel, K, Macharia, R, Amthor, H

“…Over the past decade, signalling cascades have been characterised that control key features of muscle growth, including the proliferation, differentiation of…”
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