Search Results - "Amstad, Paul A."

Increased p53 Mutation Load in Nontumorous Human Liver of Wilson Disease and Hemochromatosis: Oxyradical Overload Diseases by Hussain, S. Perwez, Raja, Kamran, Amstad, Paul A., Sawyer, Mark, Trudel, Laura J., Wogan, Gerald N., Hofseth, Lorne J., Shields, Peter G., Billiar, Timothy R., Trautwein, Christian, Hohler, Thomas, Galle, Peter R., Phillips, David H., Markin, Rodney, Marrogi, Aizen J., Harris, Curtis C.

“…Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase…”
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Effect of Bcl-2 on oxidant-induced cell death and intracellular Ca2+ mobilization by Ichimiya, M, Chang, S H, Liu, H, Berezesky, I K, Trump, B F, Amstad, P A

“…The mechanism by which Bcl-2 inhibits cell death is unknown. It has been suggested that Bcl-2 functions as an antioxidant. Because Bcl-2 is localized mainly to…”
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Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells by GIRISH SHAH, GHOSH, R, AMSTAD, P. A, CERUTTI, P. A

“…The UVB (290-320 nm) portion of the solar spectrum possesses the highest activity for the induction of skin cancer and has the capacity to stimulate epidermal…”
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bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells by Amstad, Paul A., Liu, Hui, Ichimiya, Masato, Chang, Seung, Berezesky, Irene K., Trump, Benjamin F.

“…Increased bcl‐2 expression is a common feature of many types of human malignancies, which implies that bcl‐2 plays an important role in tumorigenesis. To…”
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Mechanism of c-fos induction by active oxygen by AMSTAD, P. A, KRUPITZA, G, CERUTTI, P. A

“…We have compared the mechanisms of the transcriptional induction of c-fos in mouse epidermal cells JB6 (clone 30) by an extracellular burst of active oxygen of…”
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Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes by Cherpillod, P, Amstad, P A

“…Human tobacco-related cancers show a high frequency of G-to-T transversions in several mutation hot-spot regions of the p53 tumor suppressor gene, probably the…”
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Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells by AMSTAD, P. A, LIU, H, ICHIMIYA, M, BEREZESKY, I. K, TRUMP, B. F

“…Manganese superoxide dismutase (MnSOD) has been found to be depleted in a variety of tumor cells as well as in in vitro transformed cell lines, suggesting that…”
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Ultraviolet-B-light-induced mutagenesis of C-H-ras codons 11 and 12 in human skin fibroblasts by Amstad, P A, Cerutti, P A

“…Mutations in the ras oncogene are detected with a high frequency in non-melanoma skin cancer. Approximately half of the squamous-cell carcinomas (SCC) and one…”
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Constitutive and phorbol-myristate-acetate regulated antioxidant defense of mouse epidermal JB6 cells by Crawford, D R, Amstad, P A, Foo, D D, Cerutti, P A

“…Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the…”
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