Search Results - "Amso, Zaid"

Engineering PEG-fatty acid stapled, long-acting peptide agonists for G protein-coupled receptors by Lear, Sam, Amso, Zaid, Shen, Weijun

“…G protein-coupled receptors (GPCRs) play a key role in signal transduction and human pathophysiological processes. Family B GPCRs are activated by a number of…”
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Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist by Lear, Sam, Seo, Hyosuk, Lee, Candy, Lei, Lei, Amso, Zaid, Huang, David, Zou, Huafei, Zhou, Zhihong, Nguyen-Tran, Vân T B, Shen, Weijun

“…Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating metabolic…”
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Using Chemical Synthesis to Probe Structure–Activity Relationships of the Glycoactive Bacteriocin Glycocin F by Bisset, Sean W, Yang, Sung-Hyun, Amso, Zaid, Harris, Paul W. R, Patchett, Mark L, Brimble, Margaret A, Norris, Gillian E

“…Glycocin F, a bacteriocin produced by Lactobacillus plantarum KW30, is glycosylated with two N-acetyl-d-glucosamine sugars, and has been shown to exhibit a…”
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Synthesis of Natural Cyclopentapeptides Isolated from Dianthus chinensis by Zhang, Shengping, Amso, Zaid, De Leon Rodriguez, Luis M, Kaur, Harveen, Brimble, Margaret A

“…The first syntheses of the naturally occurring cyclic peptides dianthin I (1), pseudostellarin A (2), and heterophyllin J (3) are described. The linear…”
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α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo by Shi, Yan, Lee, Candy, Sang, Peng, Amso, Zaid, Huang, David, Zhong, Weixia, Gu, Meng, Wei, Lulu, Nguyen-Tran, Vân T.B., Zhang, Jingyao, Shen, Weijun, Cai, Jianfeng

“…Peptides are increasingly important resources for biological and therapeutic development, however, their intrinsic susceptibility to proteolytic degradation…”
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Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H by Kaur, Harveen, Heapy, Amanda M., Kowalczyk, Renata, Amso, Zaid, Watson, Maureen, Cornish, Jillian, Brimble, Margaret A.

“…The first synthesis and osteoblast proliferative activity of the naturally occurring cyclic peptides dianthins G and H is described. The greater potency of…”
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Short Anabolic Peptides for Bone Growth by Amso, Zaid, Cornish, Jillian, Brimble, Margaret A.

“…Loss of bone occurs in the age‐related skeletal disorder, osteoporosis, leading to bone fragility and increased incidence of fractures, which are associated…”
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Novel peptide binder for EphA2-targeted radiopharmaceutical therapy for multiple solid tumors by Clift, Renee, Richardson, Samantha, Ehara, Takeru, Yanagida, Hayato, Hung, Ivy, Amso, Zaid, Salvador, Katrina, Guest, Matt, Han, Guangzhou, Bhat, Abhijit, Cole, Derek, Bischoff, Eric, Li, Gary

“…e15113 Background: Ephrin type-A receptor 2 (EphA2) is a glycoprotein of the ephrin receptor subfamily. EphA2 is primarily involved in tissue patterning during…”
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New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice by Yang, Peng-Yu, Zou, Huafei, Amso, Zaid, Lee, Candy, Huang, David, Woods, Ashley K, Nguyen-Tran, Vân T. B, Schultz, Peter G, Shen, Weijun

“…Oxyntomodulin (OXM) is an intestinal peptide hormone that activates both glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors. The natural peptide…”
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Total chemical synthesis of glycocin F and analogues: S -glycosylation confers improved antimicrobial activity by Amso, Zaid, Bisset, Sean W, Yang, Sung-Hyun, Harris, Paul W R, Wright, Tom H, Navo, Claudio D, Patchett, Mark L, Norris, Gillian E, Brimble, Margaret A

“…Glycocin F (GccF) is a unique diglycosylated bacteriocin peptide that possesses potent and reversible bacteriostatic activity against a range of Gram-positive…”
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Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects by Pflimlin, Elsa, Zhou, Zhihong, Amso, Zaid, Fu, Qiangwei, Lee, Candy, Muppiddi, Avinash, Joseph, Sean B, Nguyen-Tran, Vân, Shen, Weijun

“…The effects of oxytocin on food intake and body weight reduction have been demonstrated in both animal models and human clinical studies. Despite being…”
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The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1 by Sang, Peng, Zhou, Zhihong, Shi, Yan, Lee, Candy, Amso, Zaid, Huang, David, Odom, Timothy, Nguyen-Tran, Vân T B, Shen, Weijun, Cai, Jianfeng

“…Existing long α-helix mimicking necessitates the retention of most natural amino acid residues to maintain their biological activity. Here, we report the…”
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Total chemical synthesis of glycocin F and analogues: S-glycosylation confers improved antimicrobial activityElectronic supplementary information (ESI) available: Experimental details for the synthesis of all peptides, analytical LC and HR-MS, and circular dichroism data. See DOI: 10.1039/c7sc04383j by Amso, Zaid, Bisset, Sean W, Yang, Sung-Hyun, Harris, Paul W. R, Wright, Tom H, Navo, Claudio D, Patchett, Mark L, Norris, Gillian E, Brimble, Margaret A

“…Glycocin F (GccF) is a unique diglycosylated bacteriocin peptide that possesses potent and reversible bacteriostatic activity against a range of Gram-positive…”
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Total chemical synthesis of glycocin F and analogues: S-glycosylation confers improved antimicrobial activity† †Electronic supplementary information (ESI) available: Experimental details for the synthesis of all peptides, analytical LC and HR-MS, and circular dichroism data. See DOI: 10.1039/c7sc04383j by Amso, Zaid, Bisset, Sean W., Yang, Sung-Hyun, Harris, Paul W. R., Wright, Tom H., Navo, Claudio D., Patchett, Mark L., Norris, Gillian E., Brimble, Margaret A.

“…Replacing the O -linked saccharide in the bacteriocin glycocin F with an S -linked version results in a peptidomimetic that increases the bacteriostatic…”
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Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis by Amso, Zaid, Kowalczyk, Renata, Watson, Maureen, Park, Young-Eun, Callon, Karen E, Musson, David S, Cornish, Jillian, Brimble, Margaret A

“…Preptin is a 34-residue pancreatic hormone shown to be anabolic to bone in vitro and in vivo. The bone activity of preptin resides within the (1-16) N-terminal…”
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Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G by Amso, Zaid, Kowalczyk, Renata, Park, Young-Eun, Watson, Maureen, Lin, Jian-Ming, Musson, David S, Cornish, Jillian, Brimble, Margaret A

“…The cyclohexapeptide natural product dianthin G promotes osteoblast (bone-forming cell) proliferation in vitro at nanomolar concentrations, and is therefore…”
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