Search Results - "Amrutkar, Suyog M"
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Imine/amide–imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-α inhibition
Published in Bioorganic & medicinal chemistry (01-09-2015)“…[Display omitted] Microwave-accelerated synthesis and anticancer activity of novel imine/amide–imidazole conjugates derived from 5-amino-4-cyano-N1-substituted…”
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Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors
Published in ACS medicinal chemistry letters (09-04-2015)“…A study of structure-based modulation of known ligands of hTopoIIα, an important enzyme involved in DNA processes, coupled with synthesis and in vitro assays…”
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Scaffold-Hopping of Aurones: 2‑Arylideneimidazo[1,2‑a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents
Published in ACS medicinal chemistry letters (08-12-2016)“…Scaffold-hopping of bioactive natural product aurones has been studied for the first time. 2-Arylideneimidazo[1,2-a]pyridinones as potential topoisomerase…”
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Anticancer activity of dihydropyrazolo[1,5‐c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
Published in Archiv der Pharmazie (Weinheim) (01-06-2018)“…The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were…”
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