Search Results - "Amrutkar, Manoj"

Pancreatic Cancer Chemoresistance to Gemcitabine by Amrutkar, Manoj, Gladhaug, Ivar P

“…Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, ranks among the leading causes of cancer-related deaths in the Western…”
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Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells by Amrutkar, Manoj, Aasrum, Monica, Verbeke, Caroline S, Gladhaug, Ivar P

“…Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the…”
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Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice by Caputo, Mara, Andersson, Emma, Xia, Ying, Hou, Wei, Cansby, Emmelie, Erikson, Max, Lind, Dan Emil, Hallberg, Bengt, Amrutkar, Manoj, Mahlapuu, Margit

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced subtype, metabolic dysfunction-associated steatohepatitis (MASH), have…”
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Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells by Li, Yuchuan, Amrutkar, Manoj, Finstadsveen, Anette Vefferstad, Dalen, Knut Tomas, Verbeke, Caroline S., Gladhaug, Ivar P.

“…Abstract Background Despite therapeutic advances, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is…”
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Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma by Amrutkar, Manoj, Verbeke, Caroline S., Finstadsveen, Anette Vefferstad, Dorg, Linda, Labori, Knut Jørgen, Gladhaug, Ivar P.

“…The modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on…”
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STK25 is a critical determinant in nonalcoholic steatohepatitis by Amrutkar, Manoj, Chursa, Urszula, Kern, Matthias, Nuñez‐Durán, Esther, Ståhlman, Marcus, Sütt, Silva, Borén, Jan, Johansson, Bengt R., Marschall, Hanns‐Ulrich, Blüher, Matthias, Mahlapuu, Margit

“…ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and 10–20% of patients with NAFLD progress to nonalcoholic…”
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Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model by Amrutkar, Manoj, Cansby, Emmelie, Chursa, Urszula, Nuñez-Durán, Esther, Chanclón, Belén, Ståhlman, Marcus, Fridén, Vincent, Mannerås-Holm, Louise, Wickman, Anna, Smith, Ulf, Bäckhed, Fredrik, Borén, Jan, Howell, Brian W, Mahlapuu, Margit

“…Understanding the molecular networks controlling ectopic lipid deposition, glucose tolerance, and insulin sensitivity is essential to identifying new…”
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Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis by Amrutkar, Manoj, Berg, Kjersti, Balto, Aina, Skilbrei, Miguel G, Finstadsveen, Anette V, Aasrum, Monica, Gladhaug, Ivar P, Verbeke, Caroline S

“…Profound resistance to chemotherapy remains a major challenge in achieving better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC)…”
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Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells by Lenggenhager, Daniela, Amrutkar, Manoj, Sántha, Petra, Aasrum, Monica, Löhr, Johannes-Matthias, Gladhaug, Ivar P, Verbeke, Caroline S

“…Activated pancreatic stellate cells (PSCs) play a central role in the tumor stroma of pancreatic ductal adenocarcinoma (PDAC). Given the limited availability…”
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Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor by Amrutkar, Manoj, Larsen, Emma Kristine, Aasrum, Monica, Finstadsveen, Anette Vefferstad, Andresen, Per Arne, Verbeke, Caroline S, Gladhaug, Ivar P

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely poor prognosis, and its treatment remains a challenge. As the existing in vitro…”
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Mo1138 COMPARATIVE PROTEOMICS REVEALS TRANSLATIONAL POTENTIAL OF TARGETS FOR PANCREATIC DUCTAL ADENOCARCINOMA by Resell, Mathilde, Rabben, Hanne-Line, Amrutkar, Manoj, Hagen, Lars, Batra, Surinder K., Verbeke, Caroline S., Wang, Timothy C., Chen, Duan, Zhao, Chun-Mei

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Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer by Amrutkar, Manoj, Gladhaug, Ivar P

“…Pancreatic ductal adenocarcinoma (PDAC), also known as pancreatic cancer (PC), is characterized by an overall poor prognosis and a five-year survival that is…”
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Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes by Nerstedt, Annika, Cansby, Emmelie, Amrutkar, Manoj, Smith, Ulf, Mahlapuu, Margit

“…•Activation of AMPK represses IL-6-induced inflammation in liver and HepG2 cells.•AMPK inhibits IL-6 signalling by repressing phosphorylation of JAK1, SHP2 and…”
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Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH by Amrutkar, Manoj, Cansby, Emmelie, Nuñez‐Durán, Esther, Pirazzi, Carlo, Ståhlman, Marcus, Stenfeldt, Elin, Smith, Ulf, Borén, Jan, Mahlapuu, Margit

“…Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease, and 10% to 20% of NAFLD patients progress to nonalcoholic steatohepatitis…”
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Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems by Lencioni, Giulia, Gregori, Alessandro, Toledo, Belén, Rebelo, Rita, Immordino, Benoît, Amrutkar, Manoj, Xavier, Cristina P.R., Kocijančič, Anja, Pandey, Deo Prakash, Perán, Macarena, Castaño, Justo P., Walsh, Naomi, Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis and rising global deaths. Late diagnosis, due to absent early symptoms and…”
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Silencing of STE20‐type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet‐induced nonalcoholic fatty liver disease by Caputo, Mara, Kurhe, Yeshwant, Kumari, Sima, Cansby, Emmelie, Amrutkar, Manoj, Scandalis, Eli, Booten, Sheri L., Ståhlman, Marcus, Borén, Jan, Marschall, Hanns‐Ulrich, Aghajan, Mariam, Mahlapuu, Margit

“…Nonalcoholic fatty liver disease (NAFLD) is emerging as a leading cause of chronic liver disease worldwide. Despite intensive nonclinical and clinical research…”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Amrutkar, Manoj, Guttorm, Sander Johannes Thorbjørnsen, Finstadsveen, Anette Vefferstad, Labori, Knut Jørgen, Eide, Lars, Rootwelt, Helge, Elgstøen, Katja Benedikte Prestø, Gladhaug, Ivar P., Verbeke, Caroline S.

“…Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non‐metastatic pancreatic ductal adenocarcinoma (PDAC) and is established as a…”
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Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans by Cansby, Emmelie, Kulkarni, Nagaraj M., Magnusson, Elin, Kurhe, Yeshwant, Amrutkar, Manoj, Nerstedt, Annika, Ståhlman, Marcus, Sihlbom, Carina, Marschall, Hanns‐Ulrich, Borén, Jan, Blüher, Matthias, Mahlapuu, And Margit

“…ABSTRACTEctopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks…”
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Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans by Amrutkar, Manoj, Kern, Matthias, Nuñez-Durán, Esther, Ståhlman, Marcus, Cansby, Emmelie, Chursa, Urszula, Stenfeldt, Elin, Borén, Jan, Blüher, Matthias, Mahlapuu, Margit

“…Aims/hypothesis Type 2 diabetes is closely associated with pathological lipid accumulation in the liver, which is suggested to actively contribute to the…”
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Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle by Chursa, Urszula, Nuñez-Durán, Esther, Cansby, Emmelie, Amrutkar, Manoj, Sütt, Silva, Ståhlman, Marcus, Olsson, Britt-Marie, Borén, Jan, Johansson, Maria E., Bäckhed, Fredrik, Johansson, Bengt R., Sihlbom, Carina, Mahlapuu, Margit

“…Aims/hypothesis Understanding the molecular networks controlling ectopic lipid deposition and insulin responsiveness in skeletal muscle is essential for…”
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