Search Results - "Amrite, Aniruddha"

Nanomedicines for back of the eye drug delivery, gene delivery, and imaging by Kompella, Uday B., Amrite, Aniruddha C., Pacha Ravi, Rashmi, Durazo, Shelley A.

“…Treatment and management of diseases of the posterior segment of the eye such as diabetic retinopathy, retinoblastoma, retinitis pigmentosa, and choroidal…”
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Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration by Amrite, Aniruddha C., Kompella, Uday B.

“…The purpose of this study was to determine the retention and ocular distribution of subconjunctivally administered nanoparticles and microparticles…”
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Single Periocular Injection of Celecoxib-PLGA Microparticles Inhibits Diabetes-Induced Elevations in Retinal PGE2, VEGF, and Vascular Leakage by Amrite, Aniruddha C, Ayalasomayajula, Surya P, Cheruvu, Narayan P. S, Kompella, Uday B

“…To determine whether celecoxib inhibits VEGF secretion from ARPE-19 cells and to investigate further the safety and effectiveness of periocular celecoxib-poly…”
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Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration by Amrite, Aniruddha C, Edelhauser, Henry F, Singh, Swita R, Kompella, Uday B

“…Our previous studies indicated that while 20 nm particles are rapidly cleared from the periocular space of the rat following posterior subconjunctival…”
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Effect of Eye Pigmentation on Transscleral Drug Delivery by Cheruvu, Narayan P. S, Amrite, Aniruddha C, Kompella, Uday B

“…To determine the influence of eye pigmentation on transscleral retinal delivery of celecoxib. Melanin content in ocular tissues of both the strains was…”
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Modeling of Corneal and Retinal Pharmacokinetics after Periocular Drug Administration by Amrite, Aniruddha C, Edelhauser, Henry F, Kompella, Uday B

“…To develop pharmacokinetics models to describe the disposition of small lipophilic molecules in the cornea and retina after periocular (subconjunctival or…”
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Celecoxib inhibits proliferation of retinal pigment epithelial and choroid-retinal endothelial cells by a cyclooxygenase-2-independent mechanism by Amrite, Aniruddha C, Kompella, Uday B

“…Age-related macular degeneration (ARMD) is a leading cause of blindness. The major reason for severe vision loss in ARMD is choroidal neovascularization due to…”
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Delivery of celecoxib for treating diseases of the eye: influence of pigment and diabetes by Amrite, Aniruddha, Pugazhenthi, Vidya, Cheruvu, Narayan, Kompella, Uday

“…Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are two major causes of blindness. In these disorders, growth factors such as vascular…”
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Effect of Diabetes on Transscleral Delivery of Celecoxib by Cheruvu, Narayan P. S, Amrite, Aniruddha C, Kompella, Uday B

“…Purpose To investigate the effects of diabetes on transscleral retinal delivery of celecoxib in albino and pigmented rats. Methods Albino (Sprague Dawley--SD)…”
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Nedosiran population pharmacokinetic and pharmacodynamic modelling and simulation to guide clinical development and dose selection in patients with primary hyperoxaluria type 1 by Zhang, Steven, Amrite, Aniruddha, Tan, Beesan, Jamsen, Kris, Pradhan, Sudeep, Choy, Steve, Plotkin, Horacio

“…To characterize pharmacokinetic and pharmacodynamic profiles of nedosiran in patients with primary hyperoxaluria type 1 (PH1), identify influential covariates…”
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Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas by AYALASOMAYAJULA, Surya P, AMRITE, Aniruddha C, KOMPELLA, Uday B

“…Up-regulation of cyclooxygenase-2 occurs in retinal cells during the early onset of diabetic retinopathy. Under these conditions, prostaglandin production is…”
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PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2 by Baum, Michelle A, Langman, Craig, Cochat, Pierre, Lieske, John C, Moochhala, Shabbir H, Hamamoto, Shuzo, Satoh, Hiroyuki, Mourani, Chebl, Ariceta, Gema, Torres, Armando, Wolley, Martin, Belostotsky, Vladimir, Forbes, Thomas A, Groothoff, Jaap, Hayes, Wesley, Tönshoff, Burkhard, Takayama, Tatsuya, Rosskamp, Ralf, Russell, Kerry, Zhou, Jing, Amrite, Aniruddha, Hoppe, Bernd

“…Nedosiran is an investigational RNA interference agent designed to inhibit expression of hepatic lactate dehydrogenase, the enzyme thought responsible for the…”
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Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria by Hoppe, Bernd, Koch, Annelize, Cochat, Pierre, Garrelfs, Sander F, Baum, Michelle A, Groothoff, Jaap W, Lipkin, Graham, Coenen, Martin, Schalk, Gesa, Amrite, Aniruddha, McDougall, David, Barrios, Kelly, Langman, Craig B

“…Primary hyperoxaluria (PH) is a family of ultra-rare autosomal recessive inherited disorders of hepatic glyoxylate metabolism characterized by oxalate…”
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Safety, Pharmacokinetics, and Exposure–Response Modeling of Nedosiran in Participants With Severe Chronic Kidney Disease by Amrite, Aniruddha, Fuentes, Ernesto, Marbury, Thomas C., Zhang, Steven

“…Nedosiran is an investigational RNA‐interference therapeutic in development for primary hyperoxaluria (PH). Because nedosiran undergoes renal clearance, we…”
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Quantitation of total antibody (tAb) from antibody drug conjugate (ADC) PYX-201 in rat and monkey plasma using an enzyme-linked immunosorbent assay (ELISA) and its application in preclinical studies by Yin, Feng, DeCiantis, Chris, Pinkas, Jan, Das, Biplab, Wang, Frank, Zheng, Nancy, Hahn, David, Amrite, Aniruddha, Feng, Jianwen, Adhikari, Diana, Kane, Cheikh, Sikora, Jack, Pittman, Justin, Wates, Rebecca, Shaheen, Elizabeth, Harriman, Shawn

“…PYX-201 is an investigative ADC oncology drug composed of a monoclonal human immunoglobulin G (IgG) antibody targeting the extra domain B splice variant of…”
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PHYOX2: Nedosiran Reduced Urinary Oxalate Excretion in Patients with Primary Hyperoxaluria: PO2538 by Baum, Michelle A., Langman, Craig B., Cochat, Pierre, Lieske, John C., Moochhala, Shabbir H., Hamamoto, Shuzo, Satoh, Hiroyuki, Mourani, Chebl, Ariceta, Gema, Amrite, Aniruddha, Hoppe, Bernd

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A sensitive LC–MS/MS assay to quantitate free payload Aur0101 from ADC PYX-201 in rat and monkey plasma by Yin, Feng, Ahsan, Farah, Pinkas, Jan, Das, Biplab, Wang, Frank, Zheng, Nancy, Hahn, David, Amrite, Aniruddha, Feng, Jianwen, Adhikari, Diana, Sikora, Jack, Shaheen, Elizabeth, Harriman, Shawn

“…Aur0101 is a cytotoxic and small-molecule microtubule depolymerizing agent, and is the payload conjugated to antibody–drug conjugate PYX-201. Developing and…”
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Quantification of antibody–drug conjugate PYX-201 in rat and monkey plasma via ELISA and its application in preclinical studies by Yin, Feng, DeCiantis, Chris, Pinkas, Jan, Das, Biplab, Wang, Frank, Zheng, Nancy, Hahn, David, Amrite, Aniruddha, Adhikari, Diana, Kane, Cheikh, Sikora, Jack, Pittman, Justin, Wates, Rebecca, Shaheen, Elizabeth, Harriman, Shawn

“…PYX-201 is a novel antibody–drug conjugate targeting the extra domain B splice variant of fibronectin in the tumor microenvironment. Accurate quantification of…”
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In vitro transport and partitioning of AL-4940, active metabolite of angiostatic agent anecortave acetate, in ocular tissues of the posterior segment by Missel, Paul, Chastain, James, Mitra, Ashim, Kompella, Uday, Kansara, Viral, Duvvuri, Sridhar, Amrite, Aniruddha, Cheruvu, Narayan

“…The purpose of this study was to evaluate partitioning into and transport across posterior segment tissues (sclera, retinal pigment epithelium (RPE)-choroid)…”
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Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E 2 secretion from diabetic rat retinas by Ayalasomayajula, Surya P., Amrite, Aniruddha C., Kompella, Uday B.

“…Up-regulation of cyclooxygenase-2 occurs in retinal cells during the early onset of diabetic retinopathy. Under these conditions, prostaglandin production is…”
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