Search Results - "Amoreo, Carla A"

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma by Mottini, Carla, Tomihara, Hideo, Carrella, Diego, Lamolinara, Alessia, Iezzi, Manuela, Huang, Justin K, Amoreo, Carla A, Buglioni, Simonetta, Manni, Isabella, Robinson, Frederick S, Minelli, Rosalba, Kang, Ya'an, Fleming, Jason B, Kim, Michael P, Bristow, Christopher A, Trisciuoglio, Daniela, Iuliano, Antonella, Del Bufalo, Donatella, Di Bernardo, Diego, Melisi, Davide, Draetta, Giulio F, Ciliberto, Gennaro, Carugo, Alessandro, Cardone, Luca

“…Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic…”
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HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma by Lamberti, Dante, Cristinziano, Giulia, Porru, Manuela, Leonetti, Carlo, Egan, Jan B., Shi, Chang‐Xin, Buglioni, Simonetta, Amoreo, Carla A., Castellani, Loriana, Borad, Mitesh J., Alemà, Stefano, Anastasi, Sergio, Segatto, Oreste

“…About 15% of intrahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) generated…”
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Metachronous Isolated Splenic Metastasis in a Young Patient With Renal Cell Carcinoma: Case Report and Literature Review by Costantini, Manuela, Tuderti, Gabriele, Minisola, Francesco, Pompeo, Vincenzo, Sentinelli, Steno, Amoreo, Carla A., Vallati, Giulio, Poeta, Maria L., Gallucci, Michele, Simone, Giuseppe

“…Splenic metastasis is uncommon and is usually associated with widespread disease.1,2 Isolated splenic metastases from renal cancer are also rarer and are often…”
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Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds by Carrella, Diego, Manni, Isabella, Tumaini, Barbara, Dattilo, Rosanna, Papaccio, Federica, Mutarelli, Margherita, Sirci, Francesco, Amoreo, Carla A, Mottolese, Marcella, Iezzi, Manuela, Ciolli, Laura, Aria, Valentina, Bosotti, Roberta, Isacchi, Antonella, Loreni, Fabrizio, Bardelli, Alberto, Avvedimento, Vittorio E, di Bernardo, Diego, Cardone, Luca

“…The discovery of inhibitors for oncogenic signalling pathways remains a key focus in modern oncology, based on personalized and targeted therapeutics…”
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Abstract 266: The G-quadruplex ligand EMICORON potentiates the antitumor efficacy of chemotherapy on colon cancer experimental models by Porru, Manuela, Artuso, Simona, Pompili, Luca, Caruso, Carla, Bianco, Armandodoriano, Mottolese, Marcella, Amoreo, Carla A., Biroccio, Annamaria, Leonetti, Carlo

“…Abstract Background. G-quadruplex (G4) structures, present at the telomeric ends of chromosomes and in the promoters of a wide range of genes important in cell…”
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