Search Results - "Amon, Lynn"

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease by Scriba, Thomas J, Penn-Nicholson, Adam, Shankar, Smitha, Hraha, Tom, Thompson, Ethan G, Sterling, David, Nemes, Elisa, Darboe, Fatoumatta, Suliman, Sara, Amon, Lynn M, Mahomed, Hassan, Erasmus, Mzwandile, Whatney, Wendy, Johnson, John L, Boom, W Henry, Hatherill, Mark, Valvo, Joe, De Groote, Mary Ann, Ochsner, Urs A, Aderem, Alan, Hanekom, Willem A, Zak, Daniel E

“…Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary tuberculosis disease in humans remains limited…”
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A blood RNA signature for tuberculosis disease risk: a prospective cohort study by Zak, Daniel E, PhD, Penn-Nicholson, Adam, PhD, Scriba, Thomas J, PhD, Thompson, Ethan, PhD, Suliman, Sara, PhD, Amon, Lynn M, PhD, Mahomed, Hassan, MD, Erasmus, Mzwandile, BSc, Whatney, Wendy, BScHons, Hussey, Gregory D, Prof, Abrahams, Deborah, DipMT, Kafaar, Fazlin, DipNur, Hawkridge, Tony, FCPHM, Verver, Suzanne, PhD, Hughes, E Jane, BScHons, Ota, Martin, MD, Sutherland, Jayne, PhD, Howe, Rawleigh, MD, Dockrell, Hazel M, Prof, Boom, W Henry, Prof, Thiel, Bonnie, MS, Ottenhoff, Tom H M, Prof, Mayanja-Kizza, Harriet, Prof, Crampin, Amelia C, FFPHM, Downing, Katrina, PhD, Hatherill, Mark, MD, Valvo, Joe, BS, Shankar, Smitha, MS, Parida, Shreemanta K, MD, Kaufmann, Stefan H E, Prof, Walzl, Gerhard, Prof, Aderem, Alan, PhD, Hanekom, Willem A, Prof

“…Summary Background Identification of blood biomarkers that prospectively predict progression of Mycobacterium tuberculosis infection to tuberculosis disease…”
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ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation by Nazitto, Rodolfo, Amon, Lynn M, Mast, Fred D, Aitchison, John D, Aderem, Alan, Johnson, Jarrod S, Diercks, Alan H

“…APCs such as myeloid dendritic cells (DCs) are key sentinels of the innate immune system. In response to pathogen recognition and innate immune stimulation,…”
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A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV by Johnson, Jarrod S., De Veaux, Nicholas, Rives, Alexander W., Lahaye, Xavier, Lucas, Sasha Y., Perot, Brieuc P., Luka, Marine, Garcia-Paredes, Victor, Amon, Lynn M., Watters, Aaron, Abdessalem, Ghaith, Aderem, Alan, Manel, Nicolas, Littman, Dan R., Bonneau, Richard, Ménager, Mickaël M.

“…Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing…”
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Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages by Diercks, Alan H, Podolskaia, Irina S, Murray, Tara A, Jahn, Ana N, Mai, Dat, Liu, Dong, Amon, Lynn M, Nakagawa, Yoshimi, Shimano, Hitoshi, Aderem, Alan, Gold, Elizabeth S

“…Toll-like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the…”
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A targeted proteomics-based pipeline for verification of biomarkers in plasma by Paulovich, Amanda G, Whiteaker, Jeffrey R, Lin, Chenwei, Kennedy, Jacob, Hou, Liming, Trute, Mary, Sokal, Izabela, Yan, Ping, Schoenherr, Regine M, Zhao, Lei, Voytovich, Uliana J, Kelly-Spratt, Karen S, Krasnoselsky, Alexei, Gafken, Philip R, Hogan, Jason M, Jones, Lisa A, Wang, Pei, Amon, Lynn, Chodosh, Lewis A, Nelson, Peter S, McIntosh, Martin W, Kemp, Christopher J

“…Prioritizing candidate biomarkers for verification remains a formidable obstacle to the translation of protein diagnostics to clinical applications. Whiteaker…”
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Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection by Johnson, Jarrod S., Lucas, Sasha Y., Amon, Lynn M., Skelton, Stephanie, Nazitto, Rodolfo, Carbonetti, Sara, Sather, D. Noah, Littman, Dan R., Aderem, Alan

“…Myeloid dendritic cells (DCs) have the innate capacity to sense pathogens and orchestrate immune responses. However, DCs do not mount efficient immune…”
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Autoantibody Signatures Involving Glycolysis and Splicesome Proteins Precede a Diagnosis of Breast Cancer among Postmenopausal Women by LADD, Jon J, CHAO, Timothy, MCINTOSH, Martin, LI, Christopher, PRENTICE, Ross, DISIS, Nora, HANASH, Samir, JOHNSON, Melissa M, JI QIU, CHIN, Alice, ISRAEL, Rebecca, PITTERI, Sharon J, JIANNING MAO, MEI WU, AMON, Lynn M

“…We assessed the autoantibody repertoire of a mouse model engineered to develop breast cancer and the repertoire of autoantibodies in human plasmas collected at…”
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Integrative proteomic analysis of serum and peritoneal fluids helps identify proteins that are up-regulated in serum of women with ovarian cancer by Amon, Lynn M, Law, Wendy, Fitzgibbon, Matthew P, Gross, Jennifer A, O'Briant, Kathy, Peterson, Amelia, Drescher, Charles, Martin, Daniel B, McIntosh, Martin

“…We used intensive modern proteomics approaches to identify predictive proteins in ovary cancer. We identify up-regulated proteins in both serum and peritoneal…”
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Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade by Lu, Hailing, Wagner, Wolfgang M, Gad, Ekram, Yang, Yi, Duan, Hangjun, Amon, Lynn M, Van Denend, Nathaniel, Larson, Emily R, Chang, Amy, Tufvesson, Helena, Disis, Mary L

“…Multiple TLR agonists have been shown to have antitumor effects in animal models. However, the therapeutic efficacy of TLR agonist monotherapy in cancer…”
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Detection of Elevated Plasma Levels of Epidermal Growth Factor Receptor Before Breast Cancer Diagnosis among Hormone Therapy Users by PITTERI, Sharon J, AMON, Lynn M, LAMPE, Paul D, PRENTICE, Ross L, MCLNTOSH, Martin W, HANASH, Samir M, LI, Christopher I, BUSALD BUSON, Tina, YUZHENG ZHANG, JOHNSON, Melissa M, CHIN, Alice, KENNEDY, Jacob, WONG, Chee-Hong, QING ZHANG, HONG WANG

“…Applying advanced proteomic technologies to prospectively collected specimens from large studies is one means of identifying preclinical changes in plasma…”
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Concordant Release of Glycolysis Proteins into the Plasma Preceding a Diagnosis of ER+ Breast Cancer by AMON, Lynn M, PITTERI, Sharon J, PRENTICE, Ross L, HANASH, Samir M, LI, Christopher I, MCLNTOSH, Martin, LADD, Jon J, DISIS, Mary, PORTER, Peggy, CHEE HONG WONG, QING ZHANG, LAMPE, Paul

“…Although the identification of peripheral blood biomarkers would enhance early detection strategies for breast cancer, the discovery of protein markers has…”
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Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial by Hoft, Daniel F., Blazevic, Azra, Selimovic, Asmir, Turan, Aldin, Tennant, Jan, Abate, Getahun, Fulkerson, John, Zak, Daniel E., Walker, Robert, McClain, Bruce, Sadoff, Jerry, Scott, Judy, Shepherd, Barbara, Ishmukhamedov, Jasur, Hokey, David A., Dheenadhayalan, Veerabadran, Shankar, Smitha, Amon, Lynn, Navarro, Garnet, Podyminogin, Rebecca, Aderem, Alan, Barker, Lew, Brennan, Michael, Wallis, Robert S., Gershon, Anne A., Gershon, Michael D., Steinberg, Sharon

“…We report a first-in-human trial evaluating safety and immunogenicity of a recombinant BCG, AERAS-422, over-expressing TB antigens Ag85A, Ag85B, and Rv3407 and…”
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Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling by Prentice, Ross L, Paczesny, Sophie, Aragaki, Aaron, Amon, Lynn M, Chen, Lin, Pitteri, Sharon J, McIntosh, Martin, Wang, Pei, Buson Busald, Tina, Hsia, Judith, Jackson, Rebecca D, Rossouw, Jacques E, Manson, Joann E, Johnson, Karen, Eaton, Charles, Hanash, Samir M

“…Coronary heart disease (CHD) and stroke were key outcomes in the Women's Health Initiative (WHI) randomized trials of postmenopausal estrogen and estrogen plus…”
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Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice by Spiezio, Sabrina H, Amon, Lynn M, McMillen, Timothy S, Vick, Cynthia M, Houston, Barbara A, Caldwell, Mark, Ogimoto, Kayoko, Morton, Gregory J, Kirk, Elizabeth A, Schwartz, Michael W, Nadeau, Joseph H, LeBoeuf, Renée C

“…Metabolic diseases such as obesity and atherosclerosis result from complex interactions between environmental factors and genetic variants. A panel of…”
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Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor by Wang, Yong, Coulombe, René, Cameron, Dale R., Thauvette, Louise, Massariol, Marie-Josée, Amon, Lynn M., Fink, Dominique, Titolo, Steve, Welchner, Ewald, Yoakim, Christiane, Archambault, Jacques, White, Peter W.

“…Interaction between the E2 protein and E1 helicase of human papillomaviruses (HPVs) is essential for the initiation of viral DNA replication. We recently…”
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Postmenopausal estrogen and progestin effects on the serum proteome by Pitteri, Sharon J, Hanash, Samir M, Aragaki, Aaron, Amon, Lynn M, Chen, Lin, Busald Buson, Tina, Paczesny, Sophie, Katayama, Hiroyuki, Wang, Hong, Johnson, Melissa M, Zhang, Qing, McIntosh, Martin, Wang, Pei, Kooperberg, Charles, Rossouw, Jacques E, Jackson, Rebecca D, Manson, Joann E, Hsia, Judith, Liu, Simin, Martin, Lisa, Prentice, Ross L

“…Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important…”
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Early mechanistic events in biotin dissociation from streptavidin by Stenkamp, Ronald E, Lybrand, Terry P, Stayton, Patrick S, Hyre, David E, Amon, Lynn M, Penzotti, Julie E, Le Trong, Isolde

“…The streptavidin-biotin system has provided a unique opportunity to investigate the molecular details of ligand dissociation pathways. An underlying…”
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Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains by Ajioka, Richard S., LeBoeuf, Renee C., Gillespie, Ryan R., Amon, Lynn M., Kushner, James P.

“…The highly variable clinical phenotype observed in patients homozygous for the C282Y mutation of the hereditary hemochromatosis gene ( HFE) is likely due to…”
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Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer by Schoenherr, Regine M., Kelly-Spratt, Karen S., Lin, ChenWei, Whiteaker, Jeffrey R., Liu, Tao, Holzman, Ted, Coleman, Ilsa, Feng, Li-Chia, Lorentzen, Travis D., Krasnoselsky, Alexei L., Wang, Pei, Liu, Yan, Gurley, Kay E., Amon, Lynn M., Schepmoes, Athena A., Moore, Ronald J., Camp II, David G., Chodosh, Lewis A., Smith, Richard D., Nelson, Peter S., McIntosh, Martin W., Kemp, Christopher J., Paulovich, Amanda G.

“…Purpose: We generated extensive transcriptional and proteomic profiles from a Her2‐driven mouse model of breast cancer that closely recapitulates human breast…”
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