Search Results - "Ammons, W Steve"

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer by SUN, Jessica D, QIAN LIU, HART, Charles P, JINGLI WANG, AHLUWALIA, Dharmendra, FERRARO, Damien, YAN WANG, DUAN, Jian-Xin, STEVE AMMONS, W, CURD, John G, MATTEUCCI, Mark D

“…Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered…”
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TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules by Liu, Qian, Sun, Jessica D., Wang, Jingli, Ahluwalia, Dharmendra, Baker, Amanda F., Cranmer, Lee D., Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W. Steve, Curd, John G., Matteucci, Mark D., Hart, Charles P.

“…Purpose Subregional hypoxia is a common feature of tumors and is recognized as a limiting factor for the success of radiotherapy and chemotherapy. TH-302, a…”
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Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs by Duan, Jian-Xin, Jiao, Hailong, Kaizerman, Jacob, Stanton, Timothy, Evans, James W, Lan, Leslie, Lorente, Gustavo, Banica, Monica, Jung, Don, Wang, Jinwei, Ma, Huaiyu, Li, Xiaoming, Yang, Zhijian, Hoffman, Robert M, Ammons, W. Steve, Hart, Charles P, Matteucci, Mark

“…A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug, ifosfamide. The hypoxia-selective…”
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Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer by Sun, Jessica D, Liu, Qian, Wang, Jingli, Ahluwalia, Dharmendra, Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W Steve, Curd, John G, Matteucci, Mark D, Hart, Charles P

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A Novel Alkylating Agent, Glufosfamide, Enhances the Activity of Gemcitabine In Vitro, In Vivo by Ammons, W. Steve, Wang, Jin-Wei, Yang, Zhijian, Tidmarsh, George F., Hoffman, Robert M.

“…Glufosfamide is an alkylating agent consisting of iphosphoramide mustard conjugated to glucose that is currently included in clinical studies of pancreatic…”
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In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule by Ammons, W. Steve, Bauer, Robert J., Horwitz, Arnold H., Chen, Zhi J., Bautista, Eddie, Ruan, Harry H., Abramova, Marina, Scott, Kristen R., Dedrick, Russell L.

“…ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM ), was evaluated for its in vitro and in vivo activity. The…”
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ING-1(heMAb), a Monoclonal Antibody to Epithelial Cell Adhesion Molecule, Inhibits Tumor Metastases in a Murine Cancer Model by Ruan, Harry H., Scott, Kristen R., Bautista, Eddie, Ammons, W. Steve

“…ING-1(heMAb), a human-engineered monoclonal antibody (MAb) that specifically targets the epithelial cell adhesion molecule (Ep-CAM), kills adenocarcinoma cells…”
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Recombinant Bactericidal/Permeability-Increasing Protein (rBPI21) for Treatment of Parvovirus Enteritis: A Randomized, Double-Blinded, Placebo-Controlled Trial by Otto, Cynthia M., Jackson, C. Bisque, Rogell, Emily J., Prior, Richard B., Ammons, W. Steve

“…We evaluated the ability of an antimicrobial and endotoxin‐neutralizing agent, the recombinant amino terminal fragment of bactericidal permeability‐increasing…”
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rBPI(10-193) is secreted by CHO cells and retains the activity of rBPI21 by Horwitz, Arnold H, Ammons, W Steve, Bauer, Robert J, Dedrick, Russell, Nadell, Rossana, Williams, Robert E, Liu, Pei-Syan

“…rBPI23, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), kills Gram-negative bacteria and neutralizes endotoxin…”
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Recombinant Bactericidal/Permeability-Increasing Protein (rBPI21) for Treatment of Parvovirus Enteritis: A Randomized, Double-Blinded, Placebo-Controlled Trial by Otto, Cynthia M., Jackson, C. Bisque, Rogell, Emily J., Prior, Richard B., Ammons, W. Steve

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Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit gram-negative sepsis by LIN, Y, LEACH, W. J, AMMONS, W. S

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Protective Effect of a Recombinant Amino-Terminal Fragment of Bactericidal/Permeability-Increasing Protein in Experimental Endotoxemia by Kohn, Fred R., Ammons, W. Steve, Horwitz, Arnold, Grinna, Lynn, Theofan, Georgia, Weickmann, Joachim, Kung, Ada H. C.

“…Bactericidal/permeability-increasing protein (BPI), a cationic protein found in neutrophil granules, binds with high affinity to gram-negative bacterial…”
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Protective Effects Of An N-Terminal Fragment Of Bactericidal/Permeability-Increasing Protein In Rodent Models Of Gram-Negative Sepsis: Role Of Bactericidal Properties by Ammons, W. Steve, Kohn, Fred R., Kung, Ada H. C.

“…Effects of an N-terminal fragment of bactericidal/permeability increasing protein (rBPI21) on bacterial infections were determined. Intravenous (iv) rBPI21…”
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Protective effects of a recombinant N-terminal fragment of bactericidal/permeability increasing protein on endotoxic shock in conscious rabbits by Lin, Y, Ammons, W S, Leach, W J, Kung, A H

“…Endotoxin (lipopolysaccharide, LPS) can induce shock, multiple organ failure, and death. A recombinant N-terminal fragment of bactericidal/permeability…”
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Primate spinothalamic cell responses to ureteral occlusion by Ammons, W S

“…Experiments were done to examine the effect of occlusion of the uppermost portion of the ureter on activity of spinothalamic tract (STT) neurons. Fifteen…”
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Cardiopulmonary sympathetic afferent input to lower thoracic spinal neurons by Ammons, W S

“…Spinal neuronal responses to stimulation of cardiopulmonary sympathetic afferent (CPS) fibers were studied in 25 alpha-chloralose-anesthetized cats. Eighty-two…”
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Protective effect of a recombinant fragment of bactericidal/permeability increasing protein against carbohydrate dyshomeostasis and tumor necrosis factor-alpha elevation in rat endotoxemia by Lin, Y, Kohn, F R, Kung, A H, Ammons, W S

“…Endotoxin (lipopolysaccharide, LPS), a component of the gram-negative bacterial cell wall, induces carbohydrate dyshomeostasis and the release of…”
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Tonic descending modulation of spinal neurons with renal input by Standish, A, Vizzard, M A, Ammons, W S

“…Experiments were conducted to determine the influence of tonically active descending pathways on thoracolumbar spinal neurons that respond to renal nerve…”
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Vagal Afferent Inhibition of Spinothalamic Cell Responses to Sympathetic Afferents and Bradykinin in the Monkey by Ammons, Steve W, Blair, Robert W, Foreman, Robert D

“…Effects of stimulating the left thoracic vagus nerve on the responses of spinothalamic neurons to electrical stimulation of cardiopulmonary sympathetic…”
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Effect of naloxone on baroreflex, sympathetic tone and blood pressure in the cat by Koyama, S, Manugian, V, Ammons, W S, Santiesteban, H L, Manning, J W

“…Studies were designed to determine the effect of naloxone on sympathetic nerve activity and blood pressure and, also to investigate the central effect of…”
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