Search Results - "Ammerlaan, Carola M E"
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Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip
Published in Nature protocols (01-04-2021)“…Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells…”
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Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids
Published in Journal of nanobiotechnology (15-07-2022)“…The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have…”
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Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Published in EMBO molecular medicine (07-07-2021)“…Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS , encoding the lysosomal transporter cystinosin, resulting in…”
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Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids
Published in Proceedings of the National Academy of Sciences - PNAS (07-02-2023)“…Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven valuable for studies of kidney development, disease, and therapeutic…”
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Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
Published in Cell reports (Cambridge) (23-01-2024)“…Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney…”
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R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer
Published in The Journal of pathology (01-11-2022)“…R‐spondins (RSPOs) are influential signaling molecules that promote the Wnt/β‐catenin pathway and self‐renewal of stem cells. Currently, RSPOs are emerging as…”
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