Search Results - "Amit, S"

Designing around Structural Alerts in Drug Discovery by Kalgutkar, Amit S

“…Cumulative research over several decades has implicated the involvement of reactive metabolites in many idiosyncratic adverse drug reactions (IADRs)…”
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Editorial Comment on “Disposable Cystoscopes Do not Decrease Post Renal Transplant Stent Removal Symptomatic Infection Rates” by Bhattu, Amit S.

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Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice by Choudhari, Amit S, Mandave, Pallavi C, Deshpande, Manasi, Ranjekar, Prabhakar, Prakash, Om

“…Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer…”
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Metal-associated amyloid-β species in Alzheimer's disease by Pithadia, Amit S, Lim, Mi Hee

“…[Display omitted] ► Generation and aggregation of amyloid-β, as well as its interaction/reactivity with metal ions in Alzheimer's disease. ► Involvement of…”
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University research and knowledge transfer: A dynamic view of ambidexterity in british universities by Sengupta, Abhijit, Ray, Amit S.

“…•Paper examines the intertemporal linkages between research and knowledge transfer in ambidextrous universities.•Past research has a positive marginal impact…”
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A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19 by Lokhande, Amit S., Devarajan, Padma V.

“…The global pandemic of Coronavirus Disease 2019 (COVID-19) has brought the world to a grinding halt. A major cause of concern is the respiratory distress…”
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Sepsis: The evolution in definition, pathophysiology, and management by Gyawali, Bishal, Ramakrishna, Karan, Dhamoon, Amit S

“…There has been a significant evolution in the definition and management of sepsis over the last three decades. This is driven in part due to the advances made…”
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Highly Transparent Wafer-Scale Synthesis of Crystalline WS2 Nanoparticle Thin Film for Photodetector and Humidity-Sensing Applications by Pawbake, Amit S, Waykar, Ravindra G, Late, Dattatray J, Jadkar, Sandesh R

“…In the present investigation, we report a one-step synthesis method of wafer-scale highly crystalline tungsten disulfide (WS2) nanoparticle thin film by using…”
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High-entropy alloys and metallic nanocomposites: Processing challenges, microstructure development and property enhancement by Sharma, Amit S., Yadav, Surekha, Biswas, Krishanu, Basu, Bikramjit

“…[Display omitted] Two classes of new materials, i.e. high entropy alloys (HEAs) and metallic nanocomposites offer processing related challenges, while showing…”
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Lipid droplet and peroxisome biogenesis occur at the same ER subdomains by Joshi, Amit S., Nebenfuehr, Benjamin, Choudhary, Vineet, Satpute-Krishnan, Prasanna, Levine, Tim P., Golden, Andy, Prinz, William A.

“…Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane but it is not known how sites of biogenesis are determined. We…”
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Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature by Choudhary, Vineet, Golani, Gonen, Joshi, Amit S., Cottier, Stéphanie, Schneiter, Roger, Prinz, William A., Kozlov, Michael M.

“…Lipid droplets (LDs) store fats and play critical roles in lipid and energy homeostasis. They form between the leaflets of the endoplasmic reticulum (ER)…”
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Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development by Singh, Ravi Shankar P., Walker, Gregory S., Kadar, Eugene P., Cox, Loretta M., Eng, Heather, Sharma, Raman, Bergman, Arthur J., Van Eyck, Lien, Hackman, Frances, Toussi, Sima S., Kalgutkar, Amit S., Obach, R. Scott

“…Typically human absorption, distribution, metabolism, and excretion (ADME) studies are executed using radiolabeled (e.g., carbon‐14) material, the synthesis of…”
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Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates by Kalgutkar, Amit S, Dalvie, Deepak

“…Because of the inability to predict and quantify the risk of idiosyncratic adverse drug reactions (IADRs) and because reactive metabolites (RMs) are thought to…”
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Application of ATR-FTIR spectroscopy along with regression modelling for the detection of adulteration of virgin coconut oil with paraffin oil by Amit, Jamwal, Rahul, Kumari, Shivani, Dhaulaniya, Amit S., Balan, Biji, Singh, Dileep Kumar

“…Fourier transform infrared (FTIR) spectroscopy equipped with Attenuated total reflection (ATR) was employed along with chemometrics to develop the methodology…”
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Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens by Kalgutkar, Amit S

“…Soft electrophiles (e.g., epoxides, quinones, quinone-imines, quinone-methides, etc.) generated via the oxidative bioactivation of phenyl, phenolic, amino-,…”
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Non-coding RNAs as potential therapeutic targets in breast cancer by Tomar, Deepti, Yadav, Amit S., Kumar, Dhiraj, Bhadauriya, Garima, Kundu, Gopal C.

“…Paradigm shifting studies especially involving non-coding RNAs (ncRNAs) during last few decades have significantly changed the scientific perspectives…”
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Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States by Stepan, Antonia F, Walker, Daniel P, Bauman, Jonathan, Price, David A, Baillie, Thomas A, Kalgutkar, Amit S, Aleo, Michael D

“…Because of a preconceived notion that eliminating reactive metabolite (RM) formation with new drug candidates could mitigate the risk of idiosyncratic drug…”
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The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly by Khanal, Subrat, Ghimire, Pranita, Dhamoon, Amit S

“…Adenoviridae is a family of double-stranded DNA viruses that are a significant cause of upper respiratory tract infections in children and adults. Less…”
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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice by Cokorinos, Emily C., Delmore, Jake, Reyes, Allan R., Albuquerque, Bina, Kjøbsted, Rasmus, Jørgensen, Nicolas O., Tran, Jean-Luc, Jatkar, Aditi, Cialdea, Katherine, Esquejo, Ryan M., Meissen, John, Calabrese, Matthew F., Cordes, Jason, Moccia, Robert, Tess, David, Salatto, Christopher T., Coskran, Timothy M., Opsahl, Alan C., Flynn, Declan, Blatnik, Matthew, Li, Wenlin, Kindt, Erick, Foretz, Marc, Viollet, Benoit, Ward, Jessica, Kurumbail, Ravi G., Kalgutkar, Amit S., Wojtaszewski, Jørgen F.P., Cameron, Kimberly O., Miller, Russell A.

“…The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal…”
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A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis by Joshi, Amit S, Huang, Xiaofang, Choudhary, Vineet, Levine, Tim P, Hu, Junjie, Prinz, William A

“…Saccharomyces cerevisiae contains three conserved reticulon and reticulon-like proteins that help maintain ER structure by stabilizing high membrane curvature…”
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