Search Results - "Amit, Ido"

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway by Deczkowska, Aleksandra, Weiner, Assaf, Amit, Ido

“…Alzheimer’s disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical conditions in the Western…”
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Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries by Giladi, Amir, Amit, Ido

“…The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However,…”
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Microglial immune checkpoint mechanisms by Deczkowska, Aleksandra, Amit, Ido, Schwartz, Michal

“…Microglia differentiate from progenitors that infiltrate the nascent CNS during early embryonic development. They then remain in this unique immune-privileged…”
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Single-cell genomic approaches for developing the next generation of immunotherapies by Yofe, Ido, Dahan, Rony, Amit, Ido

“…Recent progress in single-cell genomics urges its application in drug development, particularly of cancer immunotherapies. Current immunotherapy pipelines are…”
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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration by Deczkowska, Aleksandra, Keren-Shaul, Hadas, Weiner, Assaf, Colonna, Marco, Schwartz, Michal, Amit, Ido

“…A major challenge in the field of neurodegenerative diseases and brain aging is to identify the body’s intrinsic mechanism that could sense the central nervous…”
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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 by Liao, Mingfeng, Liu, Yang, Yuan, Jing, Wen, Yanling, Xu, Gang, Zhao, Juanjuan, Cheng, Lin, Li, Jinxiu, Wang, Xin, Wang, Fuxiang, Liu, Lei, Amit, Ido, Zhang, Shuye, Zhang, Zheng

“…Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage…”
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Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types by Jaitin, Diego Adhemar, Kenigsberg, Ephraim, Keren-Shaul, Hadas, Elefant, Naama, Paul, Franziska, Zaretsky, Irina, Mildner, Alexander, Cohen, Nadav, Jung, Steffen, Tanay, Amos, Amit, Ido

“…In multicellular organisms, biological function emerges when heterogeneous cell types form complex organs. Nevertheless, dissection of tissues into mixtures of…”
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Dissecting cellular crosstalk by sequencing physically interacting cells by Giladi, Amir, Cohen, Merav, Medaglia, Chiara, Baran, Yael, Li, Baoguo, Zada, Mor, Bost, Pierre, Blecher-Gonen, Ronnie, Salame, Tomer-Meir, Mayer, Johannes U., David, Eyal, Ronchese, Franca, Tanay, Amos, Amit, Ido

“…Crosstalk between neighboring cells underlies many biological processes, including cell signaling, proliferation and differentiation. Current single-cell…”
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Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq by Medaglia, Chiara, Giladi, Amir, Stoler-Barak, Liat, De Giovanni, Marco, Salame, Tomer Meir, Biram, Adi, David, Eyal, Li, Hanjie, Iannacone, Matteo, Shulman, Ziv, Amit, Ido

“…Cellular functions are strongly dependent on surrounding cells and environmental factors. Current technologies are limited in their ability to characterize the…”
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Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients by Bost, Pierre, Giladi, Amir, Liu, Yang, Bendjelal, Yanis, Xu, Gang, David, Eyal, Blecher-Gonen, Ronnie, Cohen, Merav, Medaglia, Chiara, Li, Hanjie, Deczkowska, Aleksandra, Zhang, Shuye, Schwikowski, Benno, Zhang, Zheng, Amit, Ido

“…Viruses are a constant threat to global health as highlighted by the current COVID-19 pandemic. Currently, lack of data underlying how the human host interacts…”
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Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis by Giladi, Amir, Paul, Franziska, Herzog, Yoni, Lubling, Yaniv, Weiner, Assaf, Yofe, Ido, Jaitin, Diego, Cabezas-Wallscheid, Nina, Dress, Regine, Ginhoux, Florent, Trumpp, Andreas, Tanay, Amos, Amit, Ido

“…The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent stem cells in the bone marrow remain controversial. Here we dissect…”
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Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage by Dress, Regine J., Dutertre, Charles-Antoine, Giladi, Amir, Schlitzer, Andreas, Low, Ivy, Shadan, Nurhidaya Binte, Tay, Alicia, Lum, Josephine, Kairi, Muhammad Faris Bin Mohd, Hwang, You Yi, Becht, Etienne, Cheng, Yang, Chevrier, Marion, Larbi, Anis, Newell, Evan W., Amit, Ido, Chen, Jinmiao, Ginhoux, Florent

“…Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic…”
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Clump sequencing exposes the spatial expression programs of intestinal secretory cells by Manco, Rita, Averbukh, Inna, Porat, Ziv, Bahar Halpern, Keren, Amit, Ido, Itzkovitz, Shalev

“…Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such…”
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PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model by Rosenzweig, Neta, Dvir-Szternfeld, Raz, Tsitsou-Kampeli, Afroditi, Keren-Shaul, Hadas, Ben-Yehuda, Hila, Weill-Raynal, Pierre, Cahalon, Liora, Kertser, Alex, Baruch, Kuti, Amit, Ido, Weiner, Assaf, Schwartz, Michal

“…Alzheimer’s disease (AD) is a heterogeneous disorder with multiple etiologies. Harnessing the immune system by blocking the programmed cell death receptor…”
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MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing by Keren-Shaul, Hadas, Kenigsberg, Ephraim, Jaitin, Diego Adhemar, David, Eyal, Paul, Franziska, Tanay, Amos, Amit, Ido

“…Human tissues comprise trillions of cells that populate a complex space of molecular phenotypes and functions and that vary in abundance by 4–9 orders of…”
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Impaired immune surveillance accelerates accumulation of senescent cells and aging by Ovadya, Yossi, Landsberger, Tomer, Leins, Hanna, Vadai, Ezra, Gal, Hilah, Biran, Anat, Yosef, Reut, Sagiv, Adi, Agrawal, Amit, Shapira, Alon, Windheim, Joseph, Tsoory, Michael, Schirmbeck, Reinhold, Amit, Ido, Geiger, Hartmut, Krizhanovsky, Valery

“…Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent…”
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Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C− Cells by Mildner, Alexander, Schönheit, Jörg, Giladi, Amir, David, Eyal, Lara-Astiaso, David, Lorenzo-Vivas, Erika, Paul, Franziska, Chappell-Maor, Louise, Priller, Josef, Leutz, Achim, Amit, Ido, Jung, Steffen

“…Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display…”
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Full-length transcriptome assembly from RNA-Seq data without a reference genome by Friedman, Nir, Regev, Aviv, Grabherr, Manfred G, Haas, Brian J, Yassour, Moran, Levin, Joshua Z, Thompson, Dawn A, Amit, Ido, Adiconis, Xian, Fan, Lin, Raychowdhury, Raktima, Zeng, Qiandong, Chen, Zehua, Mauceli, Evan, Hacohen, Nir, Gnirke, Andreas, Rhind, Nicholas, di Palma, Federica, Birren, Bruce W, Nusbaum, Chad, Lindblad-Toh, Kerstin

“…Reconstructing full-length transcripts from high-throughput RNA sequencing data is difficult without a reference genome sequence. Grabherr et al . describe…”
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Deciphering the state of immune silence in fatal COVID-19 patients by Bost, Pierre, De Sanctis, Francesco, Canè, Stefania, Ugel, Stefano, Donadello, Katia, Castellucci, Monica, Eyal, David, Fiore, Alessandra, Anselmi, Cristina, Barouni, Roza Maria, Trovato, Rosalinda, Caligola, Simone, Lamolinara, Alessia, Iezzi, Manuela, Facciotti, Federica, Mazzariol, Annarita, Gibellini, Davide, De Nardo, Pasquale, Tacconelli, Evelina, Gottin, Leonardo, Polati, Enrico, Schwikowski, Benno, Amit, Ido, Bronte, Vincenzo

“…Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show a…”
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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner by Jaitin, Diego Adhemar, Adlung, Lorenz, Thaiss, Christoph A., Weiner, Assaf, Li, Baoguo, Descamps, Hélène, Lundgren, Patrick, Bleriot, Camille, Liu, Zhaoyuan, Deczkowska, Aleksandra, Keren-Shaul, Hadas, David, Eyal, Zmora, Niv, Eldar, Shai Meron, Lubezky, Nir, Shibolet, Oren, Hill, David A., Lazar, Mitchell A., Colonna, Marco, Ginhoux, Florent, Shapiro, Hagit, Elinav, Eran, Amit, Ido

“…Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the…”
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