Hepatitis B virus genotypes in southwest Iran： Molecular, serological and clinical outcomes
AIM： To investigate the associations of hepatitis B virus （HBV） genotype with HBeAg and anti-HBe status, alanine aminotransferase （ALT） levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS： A total of 89 HBsAg-positive serum samples were collected from...
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| Published in: | World journal of gastroenterology : WJG Vol. 14; no. 10; pp. 1510 - 1513 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Gastroenterology and Hepatology Research Center,Namazi Hospital,Shiraz University of Medical Sciences,Shiraz,Iran%Organ Transplant Research Center,Namazi Hospital,Shiraz University of Medical Sciences,Shiraz,Iran%Department of Microbiology,School of Medicine,Shiraz University of Medical Sciences,Shiraz,Iran%Iranian Blood Transfusion Organization,Shiraz,Iran%Biotechnology Department,Pasteur Institute of Iran,Tehran,Iran%Professor Alborzi Clinical Microbiology Research Center,Shiraz University of Medical Sciences,Shiraz,Iran
14-03-2008
The WJG Press and Baishideng |
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| Online Access: | Get full text |
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| Summary: | AIM： To investigate the associations of hepatitis B virus （HBV） genotype with HBeAg and anti-HBe status, alanine aminotransferase （ALT） levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS： A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction （PCR）-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS： Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis （52.7%）. Out of 55 patients with chronic hepatitis, seven （12.7%） were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative （P = 0.01） or HBeAg-positive （P = 0.026） patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals （P = 0.24）. CONCLUSION： Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease. |
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| Bibliography: | Polymerase chain reaction Cirrhosis Iran 14-1219/R R373.21 Anti-HBe Hepatitis B virus-D Hepatitis B virus-D; Cirrhosis; Iran; Anti-HBe;Polymerase chain reaction ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Telephone: +98-711-2295023 Author contributions: Mojiri A, Rahsaz M, Salah AR, Dehyadegari MA, Jowkar Z, Ghaedi M, Heidari T and Moaddeb A performed the research; Amini-Bavil-Olyaee S, Torab A and Amirzadeh S contributed new reagents/analytic tools; Behzad-Behbahani A, Saberifirozi M and Geramizadeh B designed the research; Ardabili M, Beheshti M and Azarpira N analyzed the data; Mehrabani D afforded financial support; Behzad-Behbahani A and Mojiri A contributed equally to this work. Correspondence to: Abbas Behzad-Behbahani, School of Paramedical Sciences, Shiraz University of Medical Sciences, Meshkinfam St. 7143914693, Shiraz, Iran. behbahani_2000@yahoo.com Fax: +98-711-2289113 |
| ISSN: | 1007-9327 2219-2840 |
| DOI: | 10.3748/wjg.14.1510 |