Search Results - "Amiran, Dzutsev"

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 by McCulloch, John A., Davar, Diwakar, Rodrigues, Richard R., Badger, Jonathan H., Fang, Jennifer R., Cole, Alicia M., Balaji, Ascharya K., Vetizou, Marie, Prescott, Stephanie M., Fernandes, Miriam R., Costa, Raquel G. F., Yuan, Wuxing, Salcedo, Rosalba, Bahadiroglu, Erol, Roy, Soumen, DeBlasio, Richelle N., Morrison, Robert M., Chauvin, Joe-Marc, Ding, Quanquan, Zidi, Bochra, Lowin, Ava, Chakka, Saranya, Gao, Wentao, Pagliano, Ornella, Ernst, Scarlett J., Rose, Amy, Newman, Nolan K., Morgun, Andrey, Zarour, Hassane M., Trinchieri, Giorgio, Dzutsev, Amiran K.

“…Ample evidence indicates that the gut microbiome is a tumor-extrinsic factor associated with antitumor response to anti-programmed cell death protein-1 (PD-1)…”
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The role of the microbiota in inflammation, carcinogenesis, and cancer therapy by Dzutsev, Amiran, Goldszmid, Romina S., Viaud, Sophie, Zitvogel, Laurence, Trinchieri, Giorgio

“…Commensal microorganisms colonize barrier surfaces of all multicellular organisms, including those of humans. For more than 500 million years, commensal…”
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Microbes and Cancer by Dzutsev, Amiran, Badger, Jonathan H, Perez-Chanona, Ernesto, Roy, Soumen, Salcedo, Rosalba, Smith, Carolyne K, Trinchieri, Giorgio

“…Commensal microorganisms (the microbiota) live on all the surface barriers of our body and are particularly abundant and diverse in the distal gut. The…”
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Microbial DNA signature in plasma enables cancer diagnosis by Dzutsev, Amiran, Trinchieri, Giorgio

“…Bacteria within tumours affect progression and response to therapy; in addition, bacterial DNA can be detected in cell-free plasma. Herein, we discuss evidence…”
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White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection by Han, Seong-Ji, Glatman Zaretsky, Arielle, Andrade-Oliveira, Vinicius, Collins, Nicholas, Dzutsev, Amiran, Shaik, Jahangheer, Morais da Fonseca, Denise, Harrison, Oliver J., Tamoutounour, Samira, Byrd, Allyson L., Smelkinson, Margery, Bouladoux, Nicolas, Bliska, James B., Brenchley, Jason M., Brodsky, Igor E., Belkaid, Yasmine

“…White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance…”
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Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks by Morgun, Andrey, Dzutsev, Amiran, Dong, Xiaoxi, Greer, Renee L, Sexton, D Joseph, Ravel, Jacques, Schuster, Martin, Hsiao, William, Matzinger, Polly, Shulzhenko, Natalia

“…Despite widespread use of antibiotics for the treatment of life-threatening infections and for research on the role of commensal microbiota, our understanding…”
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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer by Dmitrieva-Posocco, Oxana, Dzutsev, Amiran, Posocco, David F., Hou, Vivianty, Yuan, Wuxing, Thovarai, Vishal, Mufazalov, Ilgiz A., Gunzer, Matthias, Shilovskiy, Igor P., Khaitov, Musa R., Trinchieri, Giorgio, Waisman, Ari, Grivennikov, Sergei I.

“…Chronic inflammation drives the progression of colorectal cancer (CRC). Increased expression of interleukin (IL)-17A is associated with poor prognosis, and…”
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Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis by Molloy, Michael J., Grainger, John R., Bouladoux, Nicolas, Hand, Timothy W., Koo, Lily Y., Naik, Shruti, Quinones, Mariam, Dzutsev, Amiran K., Gao, Ji-Liang, Trinchieri, Giorgio, Murphy, Philip M., Belkaid, Yasmine

“…Shifts in commensal microbiota composition are emerging as a hallmark of gastrointestinal inflammation. In particular, outgrowth of γ-proteobacteria has been…”
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Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair by Linehan, Jonathan L., Harrison, Oliver J., Han, Seong-Ji, Byrd, Allyson L., Vujkovic-Cvijin, Ivan, Villarino, Alejandro V., Sen, Shurjo K., Shaik, Jahangheer, Smelkinson, Margery, Tamoutounour, Samira, Collins, Nicholas, Bouladoux, Nicolas, Dzutsev, Amiran, Rosshart, Stephan P., Arbuckle, Jesse H., Wang, Chyung-Ru, Kristie, Thomas M., Rehermann, Barbara, Trinchieri, Giorgio, Brenchley, Jason M., O’Shea, John J., Belkaid, Yasmine

“…Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the…”
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Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance by Ajith, Ashwin, Mamouni, Kenza, Horuzsko, Daniel D, Musa, Abu, Dzutsev, Amiran K, Fang, Jennifer R, Chadli, Ahmed, Zhu, Xingguo, Lebedyeva, Iryna, Trinchieri, Giorgio, Horuzsko, Anatolij

“…The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in development of chronic inflammatory disorders and the inflamed tumor…”
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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment by Iida, Noriho, Dzutsev, Amiran, Stewart, C. Andrew, Smith, Loretta, Bouladoux, Nicolas, Weingarten, Rebecca A., Molina, Daniel A., Salcedo, Rosalba, Back, Timothy, Cramer, Sarah, Dai, Ren-Ming, Kiu, Hiu, Cardone, Marco, Naik, Shruti, Patri, Anil K., Wang, Ena, Marincola, Francesco M., Frank, Karen M., Belkaid, Yasmine, Trinchieri, Giorgio, Goldszmid, Romina S.

“…The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, and treatment of cancer, but it…”
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Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages by Li, Zhipeng, Gurung, Manoj, Rodrigues, Richard R, Padiadpu, Jyothi, Newman, Nolan K, Manes, Nathan P, Pederson, Jacob W, Greer, Renee L, Vasquez-Perez, Stephany, You, Hyekyoung, Hioki, Kaito A, Moulton, Zoe, Fel, Anna, De Nardo, Dominic, Dzutsev, Amiran K, Nita-Lazar, Aleksandra, Trinchieri, Giorgio, Shulzhenko, Natalia, Morgun, Andrey

“…Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impacted by microbiota remain…”
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Compartmentalized Control of Skin Immunity by Resident Commensals by Naik, Shruti, Bouladoux, Nicolas, Wilhelm, Christoph, Molloy, Michael J., Salcedo, Rosalba, Kastenmuller, Wolfgang, Deming, Clayton, Quinones, Mariam, Koo, Lily, Conlan, Sean, Spencer, Sean, Hall, Jason A., Dzutsev, Amiran, Kong, Heidi, Campbell, Daniel J., Trinchieri, Giorgio, Segre, Julia A., Belkaid, Yasmine

“…Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. However, the contribution of tissue-resident…”
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The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance by Yoshimura, Teizo, McLean, Mairi H, Dzutsev, Amiran K, Yao, Xiaohong, Chen, Keqiang, Huang, Jiaqiang, Gong, Wanghua, Zhou, Jiamin, Xiang, Yi, H Badger, Jonathan, O'hUigin, Colm, Thovarai, Vishal, Tessarollo, Lino, Durum, Scott K, Trinchieri, Giorgio, Bian, Xiu-Wu, Wang, Ji Ming

“…Commensal bacteria are critical for physiological functions in the gut, and dysbiosis in the gut may cause diseases. In this article, we report that mice…”
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Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes by Rodrigues, Richard R., Gurung, Manoj, Li, Zhipeng, García-Jaramillo, Manuel, Greer, Renee, Gaulke, Christopher, Bauchinger, Franziska, You, Hyekyoung, Pederson, Jacob W., Vasquez-Perez, Stephany, White, Kimberly D., Frink, Briana, Philmus, Benjamin, Jump, Donald B., Trinchieri, Giorgio, Berry, David, Sharpton, Thomas J., Dzutsev, Amiran, Morgun, Andrey, Shulzhenko, Natalia

“…Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating…”
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Towards enhancing the predictive value of the microbiota for cancer immunotherapy by Dzutsev, Amiran K, Goldszmid, Romina S

“…The gut microbiota has emerged as a potential determinant of immune checkpoint inhibitor (ICI) response, yet using it as a biomarker remains challenging. A…”
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Transkingdom Network Analysis (TkNA): a systems framework for inferring causal factors underlying host–microbiota and other multi-omic interactions by Newman, Nolan K., Macovsky, Matthew S., Rodrigues, Richard R., Bruce, Amanda M., Pederson, Jacob W., Padiadpu, Jyothi, Shan, Jigui, Williams, Joshua, Patil, Sankalp S., Dzutsev, Amiran K., Shulzhenko, Natalia, Trinchieri, Giorgio, Brown, Kevin, Morgun, Andrey

“…We present Transkingdom Network Analysis (TkNA), a unique causal-inference analytical framework that offers a holistic view of biological systems by…”
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Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis by Chen, Keqiang, Yoshimura, Teizo, Yao, Xiaohong, Gong, Wanghua, Huang, Jiaqiang, Dzutsev, Amiran K, McCulloch, John, O'hUigin, Colm, Bian, Xiu‐wu, Trinchieri, Giorgio, Wang, Ji Ming

“…The cathelin‐related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation‐associated carcinogenesis, and disrupted microbiome…”
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Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer by Moslehi, Roxana, Tsao, Hui-Shien, Zeinomar, Nur, Stagnar, Cristy, Fitzpatrick, Sean, Dzutsev, Amiran

“…Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk [odds…”
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Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis by Padiadpu, Jyothi, Garcia‐Jaramillo, Manuel, Newman, Nolan K, Pederson, Jacob W, Rodrigues, Richard, Li, Zhipeng, Singh, Sehajvir, Monnier, Philip, Trinchieri, Giorgio, Brown, Kevin, Dzutsev, Amiran K, Shulzhenko, Natalia, Jump, Donald B, Morgun, Andrey

“…Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic…”
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