Search Results - "Amir Mehrkar"

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform by Bhaskaran, Krishnan, Bacon, Sebastian, Evans, Stephen JW, Bates, Chris J, Rentsch, Christopher T, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Spiegelhalter, David, Smeeth, Liam, Goldacre, Ben

“…Mortality from COVID-19 shows a strong relationship with age and pre-existing medical conditions, as does mortality from other causes. We aimed to investigate…”
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Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform by Samuel, Miriam, Park, Robin Y, Eastwood, Sophie V, Eto, Fabiola, Morton, Caroline E, Stow, Daniel, Bacon, Sebastian, Mehrkar, Amir, Morley, Jessica, Dillingham, Iain, Inglesby, Peter, Hulme, William J, Khunti, Kamlesh, Mathur, Rohini, Valabhji, Jonathan, MacKenna, Brian, Finer, Sarah

“…Obesity and rapid weight gain are established risk factors for noncommunicable diseases and have emerged as independent risk factors for severe disease…”
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Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP by Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Bacon, Seb, Frampton, Adam E, Mehrkar, Amir, Inglesby, Peter, Davy, Simon, Roberts, Keith, Patalay, Praveetha, Goldacre, Ben, MacKenna, Brian, Walker, Alex J

“…Healthcare across all sectors, in the UK and globally, was negatively affected by the COVID-19 pandemic. We analysed healthcare services delivered to people…”
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Risk of emergency hospital admission related to adverse events after antibiotic treatment in adults with a common infection: impact of COVID-19 and derivation and validation of risk prediction models by Zhong, Xiaomin, Palin, Victoria, Ashcroft, Darren M, Goldacre, Ben, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C J, Massey, Jon, Inglesby, Peter, Hand, Kieran, Pate, Alexander, van Staa, Tjeerd Pieter

“…With the global challenge of antimicrobial resistance intensified during the COVID-19 pandemic, evaluating adverse events (AEs) post-antibiotic treatment for…”
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Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study by Lin, Liang-Yu, Henderson, Alasdair D, Carlile, Oliver, Dillingham, Iain, Butler-Cole, Ben F C, Marks, Michael, Briggs, Andrew, Jit, Mark, Tomlinson, Laurie A, Bates, Chris, Parry, John, Bacon, Sebastian C J, Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Eggo, Rosalind M, Herrett, Emily

“…Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined. This study aims to assess the…”
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Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY by Green, Amelia, Curtis, Helen, Hulme, William, Williamson, Elizabeth, McDonald, Helen, Bhaskaran, Krishnan, Rentsch, Christopher, Schultze, Anna, MacKenna, Brian, Mahalingasivam, Viyaasan, Tomlinson, Laurie, Walker, Alex, Fisher, Louis, Massey, Jon, Andrews, Colm, Hopcroft, Lisa, Morton, Caroline, Croker, Richard, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Evans, David, Inglesby, Peter, Hickman, George, Ward, Tom, Davy, Simon, Mathur, Rohini, Tazare, John, Eggo, Rosalind, Wing, Kevin, Wong, Angel, Forbes, Harriet, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Evans, Stephen, Smeeth, Liam, Goldacre, Ben

“…While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants…”
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Using Data to Improve Healthcare: A Case Study of Pancreatic Enzyme Replacement in Pancreatic Cancer by Varghese, Teena S, Andrews, Colm, Fisher, Louis, Goldacre, Ben, Mehrkar, Amir, Pande, Rupaly, Smith, Nadia A S, Walker, Alex J, Roberts, Keith J, Sultana, Asma, MacKenna, Brian, Lemanska, Agnieszka

“…In the UK, guidelines recommend pancreatic enzyme replacement therapy (PERT) to all people with unresectable pancreatic cancer. In 2023, we published a…”
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Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic: a cohort study of 23.5 million people in England by Green, Mark Alan, McKee, Martin, Massey, Jon, Mackenna, Brian, Mehrkar, Amir, Bacon, Seb, Macleod, John, Sheikh, Aziz, Shah, Syed Ahmar, Katikireddi, Srinivasa Vittal

“…ObjectiveTo determine whether periods of disruption were associated with increased ‘avoidable’ hospital admissions and wider social inequalities in…”
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OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England by Andrews, Colm, Schultze, Anna, Curtis, Helen, Hulme, William, Tazare, John, Evans, Stephen, Mehrkar, Amir, Bacon, Sebastian, Hickman, George, Bates, Christopher, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex

“…Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to the global…”
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients' records at source using OpenSAFELY by Andrews, Colm D, Mathur, Rohini, Massey, Jon, Park, Robin, Curtis, Helen J, Hopcroft, Lisa, Mehrkar, Amir, Bacon, Seb, Hickman, George, Smith, Rebecca, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Dillingham, Iain, Maude, Steven, O'Dwyer, Thomas, Butler-Cole, Ben F C, Bridges, Lucy, Bates, Chris, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie A, Walker, Alex J, Hulme, William J

“…Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at…”
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Protocol for an OpenSAFELY cohort study collecting patient-reported outcome measures using the TPP Airmid smartphone application and linked big data to quantify the health and economic costs of long COVID (OpenPROMPT) by Herrett, Emily, Tomlin, Keith, Lin, Liang-Yu, Tomlinson, Laurie A, Jit, Mark, Briggs, Andrew, Marks, Michael, Sandmann, Frank, Parry, John, Bates, Christopher, Morley, Jessica, Bacon, Seb, Butler-Cole, Benjamin, Mahalingasivam, Viyaasan, Dennison, Alan, Smith, Deb, Gabriel, Ethan, Mehrkar, Amir, Goldacre, Ben, Smeeth, Liam, Eggo, Rosalind M M

“…IntroductionThe impact of long COVID on health-related quality of-life (HRQoL) and productivity is not currently known. It is important to understand who is…”
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The Use of Online Consultation Systems or Remote Consulting in England Characterized Through the Primary Care Health Records of 53 Million People in the OpenSAFELY Platform: Retrospective Cohort Study by Fonseca, Martina, MacKenna, Brian, Mehrkar, Amir, Walters, Caroline E, Hickman, George, Pearson, Jonathan, Fisher, Louis, Inglesby, Peter, Bacon, Seb, Davy, Simon, Hulme, William, Goldacre, Ben, Koffman, Ofra, Bakhai, Minal

“…The National Health Service (NHS) Long Term Plan, published in 2019, committed to ensuring that every patient in England has the right to digital-first primary…”
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Patient Characteristics Associated with Repeat Antibiotic Prescribing Pre- and during the COVID-19 Pandemic: A Retrospective Nationwide Cohort Study of >19 Million Primary Care Records Using the OpenSAFELY Platform by Orlek, Alex, Harvey, Eleanor, Fisher, Louis, Mehrkar, Amir, Bacon, Seb, Goldacre, Ben, MacKenna, Brian, Ashiru-Oredope, Diane

“…COVID-19 pandemic-related pressures on primary care may have driven the inappropriate continuation of antibiotic prescriptions. Yet, prescribing modality…”
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Exploring Prior Antibiotic Exposure Characteristics for COVID-19 Hospital Admission Patients: OpenSAFELY by Yang, Ya-Ting, Wong, David, Zhong, Xiaomin, Fahmi, Ali, Ashcroft, Darren M, Hand, Kieran, Massey, Jon, Mackenna, Brian, Mehrkar, Amir, Bacon, Sebastian, Goldacre, Ben, Palin, Victoria, van Staa, Tjeerd

“…Previous studies have demonstrated the association between antibiotic use and severe COVID-19 outcomes. This study aimed to explore detailed antibiotic…”
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Safety of direct-acting oral anticoagulant (DOAC) prescribing: OpenSAFELY-TPP analysis of 20.5 million adults' electronic health records by Homan, Karen, Seeley, Rachel, Fisher, Louis, Khatri, Sajida, Smith, Katie, Jamieson, Tony, Speed, Victoria, Roberts, Carol A, Mehrkar, Amir, Bacon, Sebastian, MacKenna, Brian, Goldacre, Ben

“…During the COVID-19 pandemic many patients were switched from warfarin to direct-acting oral anticoagulants (DOACs), which require the creatinine clearance…”
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Interpreting pathology test result values with comparators (<, >) in Electronic Health Records research: an OpenSAFELY short data report by Curtis, Helen J, Fisher, Louis, Evans, David, Bacon, Sebastian, Mehrkar, Amir, Goldacre, Ben, MacKenna, Brian

“…Numeric results of pathology tests are sometimes returned as a range rather than a precise value, e.g. "<10". In health data research, test result values above…”
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The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England by Yang, Ya-Ting, Zhong, Xiaomin, Fahmi, Ali, Watts, Simon, Ashcroft, Darren M, Massey, Jon, Fisher, Louis, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C J, Goldacre, Ben, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria

“…There is concern that the COVID-19 pandemic altered the management of common infections in primary care. This study aimed to evaluate infection-coded…”
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Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data: validation study based on OpenSAFELY and UK Renal Registry by Santhakumaran, Shalini, Fisher, Louis, Zheng, Bang, Mahalingasivam, Viyaasan, Plumb, Lucy, Parker, Edward PK, Steenkamp, Retha, Morton, Caroline, Mehrkar, Amir, Bacon, Sebastian, Lyon, Sue, Konstant-Hambling, Rob, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie A, Nitsch, Dorothea

“…ObjectiveTo validate primary and secondary care codes in electronic health records to identify people receiving chronic kidney replacement therapy based on…”
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Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study by Parker, Edward PK, Tazare, John, Hulme, William J, Bates, Christopher, Carr, Edward J, Cockburn, Jonathan, Curtis, Helen J, Fisher, Louis, Green, Amelia CA, Harper, Sam, Hester, Frank, Horne, Elsie MF, Loud, Fiona, Lyon, Susan, Mahalingasivam, Viyaasan, Mehrkar, Amir, Nab, Linda, Parry, John, Santhakumaran, Shalini, Steenkamp, Retha, Sterne, Jonathan AC, Walker, Alex J, Williamson, Elizabeth J, Willicombe, Michelle, Zheng, Bang, Goldacre, Ben, Nitsch, Dorothea, Tomlinson, Laurie A

“…ObjectiveTo characterise factors associated with COVID-19 vaccine uptake among people with kidney disease in England.DesignRetrospective cohort study using the…”
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OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic by Curtis, Helen J, MacKenna, Brian, Walker, Alex J, Croker, Richard, Mehrkar, Amir, Morton, Caroline, Bacon, Seb, Hickman, George, Inglesby, Peter, Bates, Chris, Evans, David, Ward, Tom, Cockburn, Jonathan, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Williamson, Elizabeth, Hulme, William, Tomlinson, Laurie, Mathur, Rohini, Drysdale, Henry, Eggo, Rosalind M, Wong, Angel Yun, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Smeeth, Liam, Goldacre, Ben

“…BackgroundEarly in the COVID-19 pandemic, the National Health Service (NHS) recommended that appropriate patients anticoagulated with warfarin should be…”
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