Effects of metabolic syndrome on bone health in older adults: the Bushehr Elderly Health (BEH) program

Effects of metabolic syndrome on bone health in older adults: the Bushehr Elderly Health (BEH) program

Summary Based on the clinical, BMD, and TBS data of 2380 participants aged ≥ 60 which was gathered during the BEH program, stage II, we showed that MetS was positively associated with BMD, while a negative or no association was observed between MetS and TBS depending on the sex and the adjustment mo...

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Bibliographic Details
Published in:Osteoporosis international Vol. 31; no. 10; pp. 1975 - 1984
Main Authors: Bagherzadeh, M., Sajjadi-Jazi, S. M., Sharifi, F., Ebrahimpur, M., Amininezhad, F., Ostovar, A., Shafiee, G., Heshmat, R., Mehrdad, N., Razi, F., Nabipour, I., Larijani, B.
Format: Journal Article
Language:English
Published: London Springer London 01-10-2020
Springer Nature B.V
Subjects:
Absorptiometry, Photon
Aged
Bone Density
Bone mineral density
Cancellous bone
Cancellous Bone - diagnostic imaging
Cross-Sectional Studies
Dual energy X-ray absorptiometry
Endocrinology
Female
Humans
Lumbar Vertebrae
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Older people
Original Article
Orthopedics
Osteoporosis
Regression analysis
Rheumatology
Spine (lumbar)
BMD
Bone mineral densitometry
Trabecular bone score
TBS
Metabolic syndrome
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Summary:Summary Based on the clinical, BMD, and TBS data of 2380 participants aged ≥ 60 which was gathered during the BEH program, stage II, we showed that MetS was positively associated with BMD, while a negative or no association was observed between MetS and TBS depending on the sex and the adjustment model. Introduction The results of previous reports in regard to the effect of metabolic syndrome (MetS) on bone health are not conclusive. This study aimed to evaluate the association between MetS with bone mineral density (BMD) and trabecular bone score (TBS) as an indicator of bone quantity and quality, respectively. Methods Using a cross-sectional design, this study was carried out based on the data collected during the BEH Program, stage II. MetS was defined according to NCEP-ATP III criteria. BMD (at the lumbar spine and the hip) and lumbar spine TBS were assessed by dual-energy X-ray absorptiometry device. Results The data of 2380 participants (wome n  = 1228, me n  = 1152) aged ≥ 60 were analyzed. In the fully adjusted regression models (including BMI), significant associations between MetS and mean BMD were observed across all locations in men ( P values ≤ 0.001) and in the lumbar spine in women ( P value = 0.003). In addition, the prevalence of osteoporosis (based on BMD) was significantly lower in those with MetS than those without MetS in both sexes, even after full adjustments (women, OR = 0.707, P value = 0.013; men, OR = 0.563, P value = 0.001). In contrast, in age-adjusted regression analyses, the prevalence of degraded bone microarchitecture (TBS ≤ 1.2) was significantly increased in those with MetS than those without, irrespective of the participants’ sex ( P values < 0.05). The mean TBS was also negatively associated with MetS in women ( β  = − 0.075, P value = 0.007) but not in men ( β  = − 0.052, P value = 0.077), in age-adjusted regression models. However, after including BMI in the adjusted models, all significant associations between TBS values and MetS disappeared. Conclusion It seems that a positive association exists between MetS and BMD, while MetS is either not associated or negatively correlated with bone quality as measured by TBS.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-020-05455-4