Search Results - "Amini, Poorya"

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation by Stojkov, Darko, Amini, Poorya, Oberson, Kevin, Sokollik, Christiane, Duppenthaler, Andrea, Simon, Hans-Uwe, Yousefi, Shida

“…The antimicrobial defense activity of neutrophils partly depends on their ability to form neutrophil extracellular traps (NETs), but the underlying mechanism…”
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Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production by Amini, Poorya, Stojkov, Darko, Felser, Andrea, Jackson, Christopher B., Courage, Carolina, Schaller, André, Gelman, Laurent, Soriano, Maria Eugenia, Nuoffer, Jean-Marc, Scorrano, Luca, Benarafa, Charaf, Yousefi, Shida, Simon, Hans-Uwe

“…Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional…”
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NET formation can occur independently of RIPK3 and MLKL signaling by Amini, Poorya, Stojkov, Darko, Wang, Xiaoliang, Wicki, Simone, Kaufmann, Thomas, Wong, Wendy Wei‐Lynn, Simon, Hans‐Uwe, Yousefi, Shida

“…The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are…”
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Reducing systematic review burden using Deduklick: a novel, automated, reliable, and explainable deduplication algorithm to foster medical research by Borissov, Nikolay, Haas, Quentin, Minder, Beatrice, Kopp-Heim, Doris, von Gernler, Marc, Janka, Heidrun, Teodoro, Douglas, Amini, Poorya

“…Identifying and removing reference duplicates when conducting systematic reviews (SRs) remain a major, time-consuming issue for authors who manually check for…”
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Information Retrieval in an Infodemic: The Case of COVID-19 Publications by Teodoro, Douglas, Ferdowsi, Sohrab, Borissov, Nikolay, Kashani, Elham, Vicente Alvarez, David, Copara, Jenny, Gouareb, Racha, Naderi, Nona, Amini, Poorya

“…Background The COVID-19 global health crisis has led to an exponential surge in published scientific literature. In an attempt to tackle the pandemic,…”
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Ensemble of deep learning language models to support the creation of living systematic reviews for the COVID-19 literature by Knafou, Julien, Haas, Quentin, Borissov, Nikolay, Counotte, Michel, Low, Nicola, Imeri, Hira, Ipekci, Aziz Mert, Buitrago-Garcia, Diana, Heron, Leonie, Amini, Poorya, Teodoro, Douglas

“…The COVID-19 pandemic has led to an unprecedented amount of scientific publications, growing at a pace never seen before. Multiple living systematic reviews…”
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Vaccine Development in the Time of COVID-19: The Relevance of the Risklick AI to Assist in Risk Assessment and Optimize Performance by Haas, Quentin, Borisov, Nikolay, Alvarez, David Vicente, Ferdowsi, Sohrab, von Meyenn, Leonhard, Teodoro, Douglas, Amini, Poorya

“…The 2019 coronavirus (COVID-19) pandemic revealed the urgent need for the acceleration of vaccine development worldwide. Rapid vaccine development poses…”
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Evolocumab for Early Reduction of LDL Cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS) by Koskinas, Konstantinos C., Windecker, Stephan, Pedrazzini, Giovanni, Mueller, Christian, Cook, Stéphane, Matter, Christian M., Muller, Olivier, Häner, Jonas, Gencer, Baris, Crljenica, Carmela, Amini, Poorya, Deckarm, Olga, Iglesias, Juan F., Räber, Lorenz, Heg, Dik, Mach, François

“…Although guidelines recommend in-hospital initiation of high-intensity statin therapy in patients with acute coronary syndromes (ACS), low-density lipoprotein…”
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To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps by Boeltz, Sebastian, Amini, Poorya, Anders, Hans-Joachim, Andrade, Felipe, Bilyy, Rostyslav, Chatfield, Simon, Cichon, Iwona, Clancy, Danielle M., Desai, Jyaysi, Dumych, Tetiana, Dwivedi, Nishant, Gordon, Rachael Ann, Hahn, Jonas, Hidalgo, Andrés, Hoffmann, Markus H., Kaplan, Mariana J., Knight, Jason S., Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Manfredi, Angelo A., Martin, Seamus J., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Munoz, Luis E., Nakazawa, Daigo, Neeli, Indira, Nizet, Victor, Pieterse, Elmar, Radic, Marko Z, Reinwald, Christiane, Ritis, Konstantinos, Rovere-Querini, Patrizia, Santocki, Michal, Schauer, Christine, Schett, Georg, Shlomchik, Mark Jay, Simon, Hans-Uwe, Skendros, Panagiotis, Stojkov, Darko, Vandenabeele, Peter, Berghe, Tom Vanden, van der Vlag, Johan, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yousefi, Shida, Zarbock, Alexander, Herrmann, Martin

“…Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have…”
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Targeting anticoagulant protein S to improve hemostasis in hemophilia by Prince, Raja, Bologna, Luca, Manetti, Mirko, Melchiorre, Daniela, Rosa, Irene, Dewarrat, Natacha, Suardi, Silvia, Amini, Poorya, Fernández, José A., Burnier, Laurent, Quarroz, Claudia, Reina Caro, Maria Desiré, Matsumura, Yasuhiro, Kremer Hovinga, Johanna A., Griffin, John H., Simon, Hans-Uwe, Ibba-Manneschi, Lidia, Saller, François, Calzavarini, Sara, Angelillo-Scherrer, Anne

“…Improved treatments are needed for hemophilia A and B, bleeding disorders affecting 400 000 people worldwide. We investigated whether targeting protein S could…”
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Utilizing Artificial Intelligence to Manage COVID-19 Scientific Evidence Torrent with Risklick AI: A Critical Tool for Pharmacology and Therapy Development by Haas, Quentin, Alvarez, David Vicente, Borissov, Nikolay, Ferdowsi, Sohrab, von Meyenn, Leonhard, Trelle, Sven, Teodoro, Douglas, Amini, Poorya

“…The SARS-CoV-2 pandemic has led to one of the most critical and boundless waves of publications in the history of modern science. The necessity to find and…”
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Deep learning-based risk prediction for interventional clinical trials based on protocol design: A retrospective study by Ferdowsi, Sohrab, Knafou, Julien, Borissov, Nikolay, Vicente Alvarez, David, Mishra, Rahul, Amini, Poorya, Teodoro, Douglas

“…Success rate of clinical trials (CTs) is low, with the protocol design itself being considered a major risk factor. We aimed to investigate the use of deep…”
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Blocking Protein S Improves Hemostasis in Hemophilia a and B by Bologna, Luca, Prince, Raja, Manetti, Mirko, Melchiorre, Daniela, Rosa, Irene, Dewarrat, Natacha, Amini, Poorya, Fernandez, Jose A, Quarroz, Claudia, Matsumura, Yasuhiro, Kremer Hovinga, Johanna A, Yousefi, Shida, Griffin, John H., Hans-Uwe, Simon, Ibba Manneschi, Lidia, Saller, Francois, Calzavarini, Sara, Angelillo-Scherrer, Anne

“…Introduction&Aim Hemophilia A and B are X-linked disorders caused by an absence or a reduction in coagulation FVIII and respectively, FIX. Patients with…”
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CT-ADE: An Evaluation Benchmark for Adverse Drug Event Prediction from Clinical Trial Results by Yazdani, Anthony, Bornet, Alban, Khlebnikov, Philipp, Zhang, Boya, Rouhizadeh, Hossein, Amini, Poorya, Teodoro, Douglas

“…Adverse drug events (ADEs) significantly impact clinical research, causing many clinical trial failures. ADE prediction is key for developing safer medications…”
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Classification of hierarchical text using geometric deep learning: the case of clinical trials corpus by Ferdowsi, Sohrab, Borissov, Nikolay, Knafou, Julien, Amini, Poorya, Teodoro, Douglas

“…We consider the hierarchical representation of documents as graphs and use geometric deep learning to classify them into different categories. While graph…”
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