Search Results - "Amin Addetia"
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Architecture and antigenicity of the Nipah virus attachment glycoprotein
Published in Science (American Association for the Advancement of Science) (25-03-2022)“…Nipah virus (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of encephalitis and respiratory illness. The entry of HNVs…”
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Transfer of skin microbiota between two dissimilar autologous microenvironments: A pilot study
Published in PloS one (30-12-2019)“…Dysbiosis of skin microbiota is associated with several inflammatory skin conditions, including atopic dermatitis, acne, and hidradenitis suppurativa. There is…”
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Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
Published in Science (American Association for the Advancement of Science) (19-08-2022)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having…”
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SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98
Published in mBio (13-04-2021)“…RNA viruses that replicate in the cytoplasm often disrupt nucleocytoplasmic transport to preferentially translate their own transcripts and prevent host…”
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Inactivation of genes in oxidative respiration and iron acquisition pathways in pediatric clinical isolates of Small colony variant Enterobacteriaceae
Published in Scientific reports (02-04-2021)“…Isolation of bacterial small colony variants (SCVs) from clinical specimens is not uncommon and can fundamentally change the outcome of the associated…”
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Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19
Published in Scientific reports (07-04-2022)“…Rapid dissemination of SARS-CoV-2 sequencing data to public repositories has enabled widespread study of viral genomes, but studies of longitudinal specimens…”
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Chlorhexidine gluconate bathing in children with cancer or those undergoing hematopoietic stem cell transplantation: A double‐blinded randomized controlled trial from the Children's Oncology Group
Published in Cancer (01-01-2021)“…Background To the authors' knowledge, information regarding whether daily bathing with chlorhexidine gluconate (CHG) reduces central line–associated…”
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Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2
Published in PLoS pathogens (01-10-2023)“…Insectivorous Old World horseshoe bats (Rhinolophus spp.) are the likely source of the ancestral SARS-CoV-2 prior to its spillover into humans and causing the…”
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Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection
Published in PLoS neglected tropical diseases (01-04-2020)“…Developing a vaccine against Treponema pallidum subspecies pallidum, the causative agent of syphilis, remains a public health priority. Syphilis vaccine design…”
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Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection
Published in Nature communications (28-10-2022)“…Measles is the most contagious airborne viral infection and the leading cause of child death among vaccine-preventable diseases. We show here that aerosolized…”
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Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure
Published in PLoS neglected tropical diseases (01-09-2021)“…Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK…”
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Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail
Published in Cell reports (Cambridge) (27-06-2023)“…Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody responses elicited by prior vaccination and infection…”
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Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain
Published in mBio (29-06-2021)“…Measles virus (MeV) bearing a single amino acid change in the fusion protein (F)-L454W-was isolated from two patients who died of MeV central nervous system…”
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Heterogeneous Antimicrobial Susceptibility Characteristics in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
Published in mSphere (01-03-2018)“…Clinical isolates of from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug…”
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Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
Published in Science (American Association for the Advancement of Science) (19-02-2021)“…Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains…”
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Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate
Published in Journal of clinical microbiology (21-10-2020)“…The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However,…”
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SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
Published in Nature (London) (02-09-2021)“…An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape 1 – 3 , have activity against diverse sarbecoviruses 4 – 7 , and be highly protective…”
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Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates
Published in Journal of clinical virology (01-08-2020)Get full text
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Broad sarbecovirus neutralization by a human monoclonal antibody
Published in Nature (London) (02-09-2021)“…The recent emergence of SARS-CoV-2 variants of concern 1 – 10 and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the…”
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