Search Results - "Amin, Rada"

Recent applications of quantitative systems pharmacology and machine learning models across diseases by Aghamiri, Sara Sadat, Amin, Rada, Helikar, Tomáš

“…Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform describing the phenotypic interaction between drugs, biological networks,…”
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Glioma Stem Cells: GPRC5A as a Novel Predictive Biomarker and Therapeutic Target Associated with Mesenchymal and Stemness Features by Aghamiri, Sara Sadat, Amin, Rada

“…Glioblastoma multiforme (GBM) represents the deadliest form of brain cancer, characterized by complex interactions within its microenvironment. Despite the…”
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The follicular lymphoma epigenome regulates its microenvironment by Amin, Rada, Braza, Mounia S

“…Follicular lymphoma (FL) is a B-cell non-Hodgkin lymphoma of germinal center (GC) origin with a distinctive tumor microenvironment (TME) and a unique spectrum…”
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Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape by Mourcin, Frédéric, Verdière, Léa, Roulois, David, Amin, Rada, Lamaison, Claire, Sibut, Vonick, Thamphya, Brice, Pangault, Céline, Monvoisin, Céline, Huet, Sarah, Seffals, Marine, Baulande, Sylvain, Mechta-Grigoriou, Fatima, Legoix, Patricia, Rossille, Delphine, Guirriec, Marion, Léonard, Simon, Cartron, Guillaume, Salles, Gilles, Fest, Thierry, Tarte, Karin

“…Lymphoid stromal cells (LSCs) are essential organizers of immune responses. We analyzed tonsillar tissue by combining flow cytometry, in situ imaging, RNA…”
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Applications of Multimodal Artificial Intelligence in Non-Hodgkin Lymphoma B Cells by Isavand, Pouria, Aghamiri, Sara Sadat, Amin, Rada

“…Given advancements in large-scale data and AI, integrating multimodal artificial intelligence into cancer research can enhance our understanding of tumor…”
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A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery by Aghamiri, Sara Sadat, Puniya, Bhanwar Lal, Amin, Rada, Helikar, Tomáš

“…Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability to mediate inflammatory responses of the immune system. Given…”
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Tim-3 mediates T cell trogocytosis to limit antitumor immunity by Pagliano, Ornella, Morrison, Robert M, Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R, DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C, Sander, Cindy, Kirkwood, John M, Bosenberg, Marcus, Anderson, Ana C, Kuchroo, Vijay K, Kane, Lawrence P, Korman, Alan J, Rajpal, Arvind, West, Sean M, Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M

“…T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of…”
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Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders by Puniya, Bhanwar Lal, Amin, Rada, Lichter, Bailee, Moore, Robert, Ciurej, Alex, Bennett, Sydney J., Shah, Ab Rauf, Barberis, Matteo, Helikar, Tomáš

“…CD4 + T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune-related diseases. CD4 + T cells’…”
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Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function by Amin, Rada, Tripathi, Kaushlendra, Sanderson, Ralph D

“…Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and…”
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Loss of IL‐22 inhibits autoantibody formation in collagen‐induced arthritis in mice by Corneth, Odilia B. J., Reijmers, Rogier M., Mus, Adriana M.C., Asmawidjaja, Patrick S., Hamburg, Jan Piet, Papazian, Natalie, Siegers, Jurre Y., Mourcin, Frédéric, Amin, Rada, Tarte, Karin, Hendriks, Rudi W., Cupedo, Tom, Lubberts, Erik

“…Interleukin 22 (IL‐22) expression is associated with increased joint destruction and disease progression in rheumatoid arthritis (RA). Although IL‐22 is…”
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Premature replacement of μ with α immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation by Duchez, Sophie, Amin, Rada, Cogné, Nadine, Delpy, Laurent, Sirac, Christophe, Pascal, Virginie, Corthésy, Blaise, Cogné, Michel

“…Sequentially along B cell differentiation, the different classes of membrane Ig heavy chains associate with the Igα/Igβ heterodimer within the B cell receptor…”
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A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery by Amin, Rada, Aghamiri, Sara Sadat, Puniya, Bhanwar Lal, Helikar, Tomáš

“…Given the critical role of dendritic cells (DCs) in shaping immunity, they present an attractive avenue as a therapeutic target to program the immune system…”
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Identification of Novel Immunosuppressive Drug Targets for Liver Transplantation Using Genome-Scale Metabolic Modeling by Aghamiri, Sara Sadat, Puniya, Bhanwar Lal, Amin, Rada, Murry, Daryl J, Helikar, Tomáš

“…The global database on donation and transplantation reported 129,681 worldwide organ transplants in 2020, with kidneys and livers being the most commonly…”
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A computational pipeline for drug discovery in immunometabolism against autoimmune diseases by Puniya, Bhanwar Lal, Bessell, Brandt, Zhao, Zhongyuan, Loecker, Josh, Aghamiri, Sara Sadat, Mohanty, Sabyasachi, Amin, Rada, Helikar, Tomas

“…We developed a computational pipeline to study immunometabolism for drug discovery in immune mediated diseases. Our pipeline integrates RNA-seq and proteomics…”
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Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells by Boice, Michael, Salloum, Darin, Mourcin, Frederic, Sanghvi, Viraj, Amin, Rada, Oricchio, Elisa, Jiang, Man, Mottok, Anja, Denis-Lagache, Nicolas, Ciriello, Giovanni, Tam, Wayne, Teruya-Feldstein, Julie, de Stanchina, Elisa, Chan, Wing C., Malek, Sami N., Ennishi, Daisuke, Brentjens, Renier J., Gascoyne, Randy D., Cogné, Michel, Tarte, Karin, Wendel, Hans-Guido

“…The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous…”
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DC-SIGN–expressing macrophages trigger activation of mannosylated IgM B-cell receptor in follicular lymphoma by Amin, Rada, Mourcin, Frédéric, Uhel, Fabrice, Pangault, Céline, Ruminy, Philippe, Dupré, Loic, Guirriec, Marion, Marchand, Tony, Fest, Thierry, Lamy, Thierry, Tarte, Karin

“…Follicular lymphoma (FL) results from the accumulation of malignant germinal center (GC) B cells leading to the development of an indolent and largely…”
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COMO: a pipeline for multi-omics data integration in metabolic modeling and drug discovery by Bessell, Brandt, Loecker, Josh, Zhao, Zhongyuan, Aghamiri, Sara Sadat, Mohanty, Sabyasachi, Amin, Rada, Helikar, Tomáš, Puniya, Bhanwar Lal

“…Abstract Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogeneous biological datasets,…”
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Heparanase promotes myeloma stemness and in vivo tumorigenesis by Tripathi, Kaushlendra, Ramani, Vishnu C., Bandari, Shyam K., Amin, Rada, Brown, Elizabeth E., Ritchie, Joseph P., Stewart, Mark D., Sanderson, Ralph D.

“…Heparanase is known to enhance the progression of many cancer types and is associated with poor patient prognosis. We recently reported that after patients…”
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CD226 opposes TIGIT to disrupt Tregs in melanoma by Fourcade, Julien, Sun, Zhaojun, Chauvin, Joe-Marc, Ka, Mignane, Davar, Diwakar, Pagliano, Ornella, Wang, Hong, Saada, Sofiane, Menna, Carmine, Amin, Rada, Sander, Cindy, Kirkwood, John M, Korman, Alan J, Zarour, Hassane M

“…CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM…”
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Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape by Mourcin, Frédéric, Verdiére, Léa, Roulois, David, Amin, Rada, Lamaison, Claire, Sibut, Vonick, Thamphya, Brice, Pangault, Céline, Monvoisin, Céline, Huet, Sarah, Seffals, Marine, Baulande, Sylvain, Mechta-Grigoriou, Fatima, Legoix, Patricia, Rossille, Delphine, Guirriec, Marion, Léonard, Simon, Cartron, Guillaume, Salles, Gilles, Fest, Thierry, Tarte, Karin

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