Search Results - "Amin, Parth"
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Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
Published in PLoS pathogens (01-06-2019)“…Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic…”
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An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response
Published in The Journal of biological chemistry (01-02-2023)“…In response to environmental stresses, cells invoke translational control to conserve resources and rapidly reprogram gene expression for optimal adaptation. A…”
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Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression
Published in Biochimica et biophysica acta. Molecular cell research (01-03-2019)“…Cell migration is a critical mechanism controlling tissue morphogenesis, epithelial wound healing and tumor metastasis. Migrating cells depend on orchestrated…”
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TgIF2K-B Is an eIF2α Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity
Published in mBio (26-01-2021)“…is an obligate intracellular parasite that persists in its vertebrate hosts in the form of dormant tissue cysts, which facilitate transmission through…”
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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Published in eLife (15-09-2022)“…A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we…”
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Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells
Published in mBio (07-07-2020)“…is an intracellular parasite that reconfigures its host cell to promote pathogenesis. One consequence of parasitism is increased migratory activity of host…”
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The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids
Published in The Journal of biological chemistry (01-11-2021)“…Healing of cutaneous wounds requires the collective migration of epithelial keratinocytes to seal the wound bed from the environment. However, the signaling…”
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Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer
Published in The FASEB journal (01-05-2022)“…The Integrated Stress Response (ISR) plays a critical role in the adaptation and survival of tumor cells to exogenous and endogenous stresses. The ISR features…”
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Endovascular recanalization of total occlusions of the mesenteric and celiac arteries
Published in Journal of vascular surgery (01-06-2012)“…Objective To evaluate our experience with the endovascular treatment of total occlusions of the mesenteric and celiac arteries. Methods We performed a…”
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Recreational Marijuana Use and Acute Myocardial Infarction: Insights from Nationwide Inpatient Sample in the United States
Published in Curēus (Palo Alto, CA) (03-11-2017)“…Background Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our…”
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Setting out into Practice: Preparing for the Future, today
Published in The Journal of thoracic and cardiovascular surgery (01-10-2017)Get full text
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Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts
Published in PloS one (03-02-2016)“…In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and…”
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Dose-Dependent Effects of Ethanol and E. Coli on Gut Permeability and Cytokine Production
Published in The Journal of surgical research (01-12-2009)“…Introduction The gut may prime inflammatory responses following shock/trauma insults. Ethanol (EtOH) use is common in trauma patients and may impair intestinal…”
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Conversion of Intestinal Bypass to Roux-en-Y Gastric Bypass: A Case Report and Brief Review
Published in Obesity surgery (01-06-2010)“…Intestinal bypass procedures for the treatment of morbid obesity have been largely replaced by Roux-en-Y gastric bypass procedures. The main reason for this…”
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Hybrid Arch Debranching and Endograft Repair in a Patient with a Ruptured Thoracic Aortic Aneurysm
Published in Journal of cardiac surgery (01-03-2014)“…Recent advances in hybrid techniques of aortic arch debranching allow for the repair of thoracic aortic arch aneurysm without requiring cardiopulmonary bypass…”
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T-cell cytokines affect mucosal immunoglobulin A transport
Published in The American journal of surgery (01-07-2007)“…Abstract Background Secretory immunoglobulin A (sIgA) is the principle immune defense against bacteria and other pathogens in the gut and other mucosal…”
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Endovascular Management of Ruptured/Leaking Descending Thoracic and Visceral Aortic Aneurysms Using Branch Snorkels Technique
Published in Journal of vascular surgery (01-10-2012)Get full text
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Anatomic Bifurcated Reconstruction of Chronic Bilateral Innominate–Superior Vena Cava Occlusion Using the Y-Stenting Technique
Published in Annals of vascular surgery (01-02-2012)“…This article presents the case of a 42-year-old man who presented with superior vena cava (SVC) syndrome due to fibrosing mediastinitis with multiple failed…”
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QS385. Immunoglobulin A Decreases Neutrophil TNF Alpha Production
Published in The Journal of surgical research (2008)Get full text
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