Search Results - "Amin, Noha H."

FDA-Validated Ecofriendly Chromatographic Methods for Simultaneous Determination of Gemcitabine and Sorafenib: Applications to Pharmacokinetics by Sharkawi, Marco M. Z., Mohamed, Norhan R., El-Saadi, Mohammed T., Amin, Noha H.

“…Combination therapy of gemcitabine and sorafenib is synergistically effective and well tolerated in patients with non-small cell lung cancer (NSCLC). In this…”
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Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents by Gawad, Nagwa M. Abd-El, Georgey, Hanan H., Ibrahim, Nashwa A., Amin, Noha H., Abdelsalam, Rania M.

“…Novel dihydropyrazole 5–8, 10 and pyrazole derivatives 12, 14, 15, 17 were synthesized. The structures of the newly synthesized compounds were elucidated by…”
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Design, synthesis and mechanistic study of new 1,2,4-triazole derivatives as antimicrobial agents by Amin, Noha H., El-Saadi, Mohamed T., Ibrahim, Ahmed A., Abdel-Rahman, Hamdy M.

“…[Display omitted] •5-Amino-1,2,4-triazoles and 1,2,4-triazolo[1,5-a]pyrimidines were synthesized.•They were screened for antimicrobial activity and…”
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Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors by Mohamed, Heba S., Amin, Noha H., El-Saadi, Mohammed T., Abdel-Rahman, Hamdy M.

“…[Display omitted] •A series 1,2,4-triazolo[1,5-a] pyrimidines was designed and synthesized.•Compounds 4a-f, 4j-l,4n-o, 5a-c were evaluated for…”
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Determination of Bendamustine, Gemcitabine and Vinorelbine (BEGEV) regimen in spiked human plasma using multivariate model update chemometric methods by Sharkawi, Marco M.Z., Mohamed, Norhan R., El-Saadi, Mohammed T., Amin, Noha H.

“…[Display omitted] •Determination of bendamustine, gemcitabine and Vinorelbine (BEGEV) regimen.•Multivariate model update chemometric methods.•Partial least…”
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Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS by Abdellatif, Khaled R.A., Belal, Amany, El-Saadi, Mohamed T., Amin, Noha H., Said, Eman G., Hemeda, Loah R.

“…[Display omitted] •A series of hybridized benzothiazole pyrimidine-based on targeting EGFR/HER2 and TS enzymes was designed and synthesized.•They were…”
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Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks by Abdelazeem, Ahmed H., Safi El-Din, Asmaa G., Abdel-Fattah, Maha M., Amin, Noha H., El-Moghazy, Samir M., El-Saadi, Mohammed T.

“…Herein we describe our efforts to develop novel anti-inflammatory/analgesic agents devoid of known cardiovascular drawbacks. In doing so, two…”
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Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents by Ismael, Ahmed S., Amin, Noha H., Elsaadi, Mohammed T., Abdel-Rahman, Hamdy M.

“…[Display omitted] •Design and synthesis of 21 new imidazo[1,2-a]pyridine derivatives.•The cytotoxic activity of the new compounds was screened against NCI 60…”
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Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities by Abdelatef, Shaimaa A., El-Saadi, Mohammed T., Amin, Noha H., Abdelazeem, Ahmed H., Omar, Hany A., Abdellatif, Khaled R.A.

“…A novel series of spirobenzo[h]chromene and spirochromane derivatives was designed, synthesized and evaluated as potential anticancer agents against MCF-7…”
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Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers by Amin, Noha H., Elsaadi, Mohammed T., Zaki, Shimaa S., Abdel-Rahman, Hamdy M.

“…[Display omitted] •Styrylquinazolines conjugated with aniline or sulfonamides targeting EGFR were synthesized.•Anticancer screening, MTT, EGFR/ A549…”
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Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities by Edrees, Fadwa H, Saad, Ahmed S, Alsaadi, Mohammed T, Amin, Noha H, Abdelwahab, Nada S

“…Recently, experimental design has beaten the traditional optimization approach (one variable at a time) by providing better quality for chromatographic…”
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Determination of Gemcitabine and Sorafenib in Spiked Human Plasma Using Multivariate Model Update Chemometric Methods by Sharkawi, Marco M Z, Mohamed, Norhan R, El-Saadi, Mohammed T, Amin, Noha H

“…Abstract Background Gemcitabine (GEM), a pyrimidine nucleoside, has been used as a first-line treatment in non-small-cell lung cancer (NSCLC). Sorafenib (SOR),…”
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Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity by Sharkawi, Marco M.Z., Mohamed, Norhan R., El-Saadi, Mohammed T., Amin, Noha H.

“…[Display omitted] •Simultaneous determination of amlodipine besylate, celecoxib and 4-methylacetophenone.•Dual wave length in ratio spectra and successive…”
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Ecofriendly LC-MS/MS and TLC-densitometric methods for simultaneous quantitative assay and monitoring of BEGEV regimen, in vivo pharmacokinetic study application by Sharkawi, Marco M Z, Mohamed, Norhan R, El-Saadi, Mohammed T, Amin, Noha H

“…To date no analytical method has been developed for the determination of the BEGEV regimen and no study has investigated the kinetic interaction between the…”
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Development of certain aminoquinazoline scaffolds as potential multitarget anticancer agents with apoptotic and anti-proliferative effects: Design, synthesis and biological evaluation by Amin, Noha H., El-Saadi, Mohammed T., Abdel-Fattah, Maha M., Mohammed, Asmaa A., Said, Eman G.

“…[Display omitted] •Aminoquinazoline derivatives were synthesized and screened for cytotoxicity at NCI.•Five- doses cytotoxicity of compound 5e against NCI 60…”
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Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines by Abdel Gawad, Nagwa M., Amin, Noha H., Elsaadi, Mohammed T., Mohamed, Fatma M.M., Angeli, Andrea, De Luca, Viviana, Capasso, Clemente, Supuran, Claudiu T.

“…[Display omitted] A series of 4-(thiazol-2-ylamino)-benzenesulfonamides was synthesized and screened for their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory…”
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Simultaneous estimation of dimenhydrinate, cinnarizine and their toxic impurities benzophenone and diphenylmethylpiperazine; in silico toxicity profiling of impurities by Abdelwahab, Nada S, Edrees, Fadwa H, Alsaadi, Mohammed T, Amin, Noha H, Saad, Ahmed S

“…The British Pharmacopeia (BP) reported that the carcinogenic and hepatotoxic, benzophenone (BZP) is a dimenhydrinate (DMH) impurity. On the other hand,…”
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Validated green chromatographic methods for determination of amlodipine and celecoxib in presence of methylacetophenone by Z Sharkawi, Marco M, Mohamed, Norhan R, El-Saadi, Mohammed T, Amin, Noha H

“…Green, accurate and rapid methods, namely LC–MS/MS and thin layer chromatography-densitometric methods, were developed for determination of amlodipine besylate…”
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Novel 4-methylsulfonylphenyl derivatives as NSAIDS with preferential COX-2 inhibition by Amin, Noha H, Mohammed, Asmaa A, Abdellatif, Khaled RA

“…There has been an enormous commercial development following the introduction of selective COX-2 inhibitors. Efforts are continuously done to discover efficient…”
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New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents by Abdellatif, Khaled Ra, El-Saadi, Mohammed T, Elzayat, Shaimaa G, Amin, Noha H

“…Everyday studies prove the increasing need for newer and safer agents to control cellular inflammatory response, an underlying cause for the pathophysiology of…”
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