Search Results - "Amin, Neal D"

Generation of Functional Human 3D Cortico-Motor Assembloids by Andersen, Jimena, Revah, Omer, Miura, Yuki, Thom, Nicholas, Amin, Neal D., Kelley, Kevin W., Singh, Mandeep, Chen, Xiaoyu, Thete, Mayuri Vijay, Walczak, Elisabeth M., Vogel, Hannes, Fan, H. Christina, Paşca, Sergiu P.

“…Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components…”
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Maturation and circuit integration of transplanted human cortical organoids by Revah, Omer, Gore, Felicity, Kelley, Kevin W., Andersen, Jimena, Sakai, Noriaki, Chen, Xiaoyu, Li, Min-Yin, Birey, Fikri, Yang, Xiao, Saw, Nay L., Baker, Samuel W., Amin, Neal D., Kulkarni, Shravanti, Mudipalli, Rachana, Cui, Bianxiao, Nishino, Seiji, Grant, Gerald A., Knowles, Juliet K., Shamloo, Mehrdad, Huguenard, John R., Deisseroth, Karl, Pașca, Sergiu P.

“…Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease 1 – 5 . However, organoids lack the…”
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Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure by Amin, Neal D., Bai, Ge, Klug, Jason R., Bonanomi, Dario, Pankratz, Matthew T., Gifford, Wesley D., Hinckley, Christopher A., Sternfeld, Matthew J., Driscoll, Shawn P., Dominguez, Bertha, Lee, Kuo-Fen, Jin, Xin, Pfaff, Samuel L.

“…Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting motoneurons. One miRNA, miR-218, is abundantly and selectively expressed…”
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Building Models of Brain Disorders with Three-Dimensional Organoids by Amin, Neal D., Paşca, Sergiu P.

“…Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem…”
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Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells by Sternfeld, Matthew J, Hinckley, Christopher A, Moore, Niall J, Pankratz, Matthew T, Hilde, Kathryn L, Driscoll, Shawn P, Hayashi, Marito, Amin, Neal D, Bonanomi, Dario, Gifford, Wesley D, Sharma, Kamal, Goulding, Martyn, Pfaff, Samuel L

“…Flexible neural networks, such as the interconnected spinal neurons that control distinct motor actions, can switch their activity to produce different…”
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Detecting microRNA-mediated gene regulatory effects in murine neuronal subpopulations by Amin, Neal D., Senturk, Gokhan, Hayashi, Marito, Driscoll, Shawn P., Pfaff, Samuel L.

“…microRNAs (miRNAs) have unique gene regulatory effects in different neuronal subpopulations. Here, we describe a protocol to identify neuronal subtype-specific…”
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Mouse embryo models built from stem cells take shape in a dish by Amin, Neal D., Pașca, Sergiu P.

“…Two groups have grown self-organizing models of mouse embryos from stem cells in vitro . The models mimic mid-gestation embryos, providing an unparalleled…”
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A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose by Amin, Neal D., Senturk, Gokhan, Costaguta, Giancarlo, Driscoll, Shawn, O’Leary, Brendan, Bonanomi, Dario, Pfaff, Samuel L.

“…Disruption of homeostatic microRNA (miRNA) expression levels is known to cause human neuropathology. However, the gene regulatory and phenotypic effects of…”
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Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets by Osseward, 2nd, Peter J, Amin, Neal D, Moore, Jeffrey D, Temple, Benjamin A, Barriga, Bianca K, Bachmann, Lukas C, Beltran, Jr, Fernando, Gullo, Miriam, Clark, Robert C, Driscoll, Shawn P, Pfaff, Samuel L, Hayashi, Marito

“…Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each…”
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Neuronal defects in a human cellular model of 22q11.2 deletion syndrome by Khan, Themasap A., Revah, Omer, Gordon, Aaron, Yoon, Se-Jin, Krawisz, Anna K., Goold, Carleton, Sun, Yishan, Kim, Chul Hoon, Tian, Yuan, Li, Min-Yin, Schaepe, Julia M., Ikeda, Kazuya, Amin, Neal D., Sakai, Noriaki, Yazawa, Masayuki, Kushan, Leila, Nishino, Seiji, Porteus, Matthew H., Rapoport, Judith L., Bernstein, Jonathan A., O’Hara, Ruth, Bearden, Carrie E., Hallmayer, Joachim F., Huguenard, John R., Geschwind, Daniel H., Dolmetsch, Ricardo E., Paşca, Sergiu P.

“…22q11.2 deletion syndrome (22q11DS) is a highly penetrant and common genetic cause of neuropsychiatric disease. Here we generated induced pluripotent stem…”
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Single-cell transcriptomic landscape of the developing human spinal cord by Andersen, Jimena, Thom, Nicholas, Shadrach, Jennifer L., Chen, Xiaoyu, Onesto, Massimo Mario, Amin, Neal D., Yoon, Se-Jin, Li, Li, Greenleaf, William J., Müller, Fabian, Pașca, Anca M., Kaltschmidt, Julia A., Pașca, Sergiu P.

“…Understanding spinal cord assembly is essential to elucidate how motor behavior is controlled and how disorders arise. The human spinal cord is exquisitely…”
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Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity by Martins, Luis F., Brambilla, Ilaria, Motta, Alessia, de Pretis, Stefano, Bhat, Ganesh Parameshwar, Badaloni, Aurora, Malpighi, Chiara, Amin, Neal D., Imai, Fumiyasu, Almeida, Ramiro D., Yoshida, Yutaka, Pfaff, Samuel L., Bonanomi, Dario

“…The nervous system requires metabolites and oxygen supplied by the neurovascular network, but this necessitates close apposition of neurons and endothelial…”
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Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide–polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis by Ferreras, Julian A., Gupta, Akash, Amin, Neal D., Basu, Arijit, Sinha, Barij N., Worgall, Stefan, Jayaprakash, Venkatesan, Quadri, Luis E.N.

“…Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide–polyketide origin. Compounds with…”
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From stem cells to embryo models in the laboratory by Amin, Neal D, Pasca, Sergiu P

“…Mouse embryonic stem cells (mESCs) isolated from blastocysts can be maintained in culture7,8 and coaxed to generate specific cell lineages. The larger size of…”
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