Search Results - "Amin, Amit Dipak"

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer by Liu, Guangbo, Pei, Fen, Yang, Fengqing, Li, Lingxiao, Amin, Amit Dipak, Liu, Songnian, Buchan, J Ross, Cho, William C

“…Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and…”
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Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial by Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.

“…We previously reported the results of a randomized phase II trial (NCT02904954) in patients with early-stage non-small cell lung cancer (NSCLC) who were…”
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A global requirement for the HIR complex in the assembly of chromatin by Amin, Amit Dipak, Vishnoi, Nidhi, Prochasson, Philippe

“…Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to carry out various cellular functions,…”
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Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial by Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.

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The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance by Amin, Amit Dipak, Chaix, Alexandre B H, Mason, Robert P, Badge, Richard M, Borts, Rhona H

“…The Saccharomyces cerevisiae RecQ helicase Sgs1 is essential for mitotic and meiotic genome stability. The stage at which Sgs1 acts during meiosis is subject…”
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Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells by Amin, Amit Dipak, Rajan, Soumya S., Groysman, Matthew J., Pongtornpipat, Praechompoo, schatz, Jonathan H.

“…Acquired resistance to targeted inhibitors remains a major, and inevitable, obstacle in the treatment of oncogene-addicted cancers. Newer-generation inhibitors…”
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A molecular single-cell lung atlas of lethal COVID-19 by Melms, Johannes C., Biermann, Jana, Huang, Huachao, Wang, Yiping, Nair, Ajay, Tagore, Somnath, Katsyv, Igor, Rendeiro, André F., Amin, Amit Dipak, Schapiro, Denis, Frangieh, Chris J., Luoma, Adrienne M., Filliol, Aveline, Fang, Yinshan, Ravichandran, Hiranmayi, Clausi, Mariano G., Alba, George A., Rogava, Meri, Chen, Sean W., Ho, Patricia, Montoro, Daniel T., Kornberg, Adam E., Han, Arnold S., Bakhoum, Mathieu F., Anandasabapathy, Niroshana, Suárez-Fariñas, Mayte, Bakhoum, Samuel F., Bram, Yaron, Borczuk, Alain, Guo, Xinzheng V., Lefkowitch, Jay H., Marboe, Charles, Lagana, Stephen M., Del Portillo, Armando, Tsai, Emily J., Zorn, Emmanuel, Markowitz, Glen S., Schwabe, Robert F., Schwartz, Robert E., Elemento, Olivier, Saqi, Anjali, Hibshoosh, Hanina, Que, Jianwen, Izar, Benjamin

“…Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2 infection 1 , 2 , but the host response at the lung tissue level is poorly…”
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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis by Filliol, Aveline, Saito, Yoshinobu, Nair, Ajay, Dapito, Dianne H., Yu, Le-Xing, Ravichandra, Aashreya, Bhattacharjee, Sonakshi, Affo, Silvia, Fujiwara, Naoto, Su, Hua, Sun, Qiuyan, Savage, Thomas M., Wilson-Kanamori, John R., Caviglia, Jorge M., Chin, LiKang, Chen, Dongning, Wang, Xiaobo, Caruso, Stefano, Kang, Jin Ku, Amin, Amit Dipak, Wallace, Sebastian, Dobie, Ross, Yin, Deqi, Rodriguez-Fiallos, Oscar M., Yin, Chuan, Mehal, Adam, Izar, Benjamin, Friedman, Richard A., Wells, Rebecca G., Pajvani, Utpal B., Hoshida, Yujin, Remotti, Helen E., Arpaia, Nicholas, Zucman-Rossi, Jessica, Karin, Michael, Henderson, Neil C., Tabas, Ira, Schwabe, Robert F.

“…Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease…”
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Non-cell-autonomous cancer progression from chromosomal instability by Li, Jun, Hubisz, Melissa J., Earlie, Ethan M., Duran, Mercedes A., Hong, Christy, Varela, Austin A., Lettera, Emanuele, Deyell, Matthew, Tavora, Bernardo, Havel, Jonathan J., Phyu, Su M., Amin, Amit Dipak, Budre, Karolina, Kamiya, Erina, Cavallo, Julie-Ann, Garris, Christopher, Powell, Simon, Reis-Filho, Jorge S., Wen, Hannah, Bettigole, Sarah, Khan, Atif J., Izar, Benjamin, Parkes, Eileen E., Laughney, Ashley M., Bakhoum, Samuel F.

“…Chromosomal instability (CIN) is a driver of cancer metastasis 1 – 4 , yet the extent to which this effect depends on the immune system remains unknown. Using…”
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Dissecting the treatment-naive ecosystem of human melanoma brain metastasis by Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang T T, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Jr, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, Izar, Benjamin

“…Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary…”
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Association of circulating CD103 + T cells with major pathological response in a randomized phase 2 trial of neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small cell lung cancer by Walsh, Zachary, Melms, Johannes C, Rogava, Meri, Caprio, Lindsay, Ager, Casey, Amin, Amit Dipak, Ho, Patricia, Malbari, Murtaza, Mittal, Vivek, McGraw, Timothy, Altorki, Nasser K., Izar, Benjamin

“…8550 Background: We previously reported results of a randomized phase 2 study, demonstrating a higher rate of major pathological response to durvalumab in…”
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Multi-modal single-cell profiling of sarcomas from archival tissue reveals mechanisms of resistance to immune checkpoint inhibitors by Caldwell, Blake, Bose, Sminu, Amin, Amit Dipak, Tagore, Somnath, Melms, Johannes C, Berhe, Simon, Ingham, Matthew, Schwartz, Gary K., Izar, Benjamin

“…e23518 Background: Single-cell RNA-seq is an enabling technology that may inform the molecular underpinnings of drug response and resistance in patient…”
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Single-cell profiling of sarcomas from archival tissue reveals programs associated with resistance to immune checkpoint blockade by Luthria, Karan, Shah, Parin, Caldwell, Blake, Melms, Johannes C, Abuzaid, Sinan, Jakubikova, Viktoria, Brodtman, D Zack, Bose, Sminu, Amin, Amit Dipak, Ho, Patricia, Biermann, Jana, Tagore, Somnath, Ingham, Matthew, Schwartz, Gary K, Izar, Benjamin

“…Sarcoma encompasses a diverse group of cancers that are typically resistant to current therapies, including immune checkpoint blockade (ICB), and underlying…”
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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity by Ho, Patricia, Melms, Johannes C., Rogava, Meri, Frangieh, Chris J., Poźniak, Joanna, Shah, Shivem B., Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T., Soni, Rajesh Kumar, Ager, Casey R., Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K., Vasan, Neil, Bakhoum, Samuel F., Reiner, Steven L., Bernatchez, Chantale, Sykes, Megan, Mace, Emily M., Wucherpfennig, Kai W., Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K., Marine, Jean-Christophe, Izar, Benjamin

“…The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures,…”
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Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens by Wang, Yiping, Fan, Joy Linyue, Melms, Johannes C., Amin, Amit Dipak, Georgis, Yohanna, Barrera, Irving, Ho, Patricia, Tagore, Somnath, Abril-Rodríguez, Gabriel, He, Siyu, Jin, Yinuo, Biermann, Jana, Hofree, Matan, Caprio, Lindsay, Berhe, Simon, Khan, Shaheer A., Henick, Brian S., Ribas, Antoni, Macosko, Evan Z., Chen, Fei, Taylor, Alison M., Schwartz, Gary K., Carvajal, Richard D., Azizi, Elham, Izar, Benjamin

“…Single-cell genomics enables dissection of tumor heterogeneity and molecular underpinnings of drug response at an unprecedented resolution 1 – 11 . However,…”
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CRISPR/Cas9 Generation of Npm1-Alk in Transplantable Murine Hematopoietic Stem Cells Accurately Models ALK-Positive Lymphoma in Recipients by Sundara Rajan, Soumya, Li, Lingxiao, Kunkalla, Kranthi, Amin, Amit Dipak, Agarwal, Nitin, Vega, Francisco, Schatz, Jonathan H.

“…Chromosomal rearrangements resulting in generation of novel fusion oncogenes are common in hematologic malignancies. These disease drivers are key therapeutic…”
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Multi-modal single-cell and whole-genome sequencing of small, frozen clinical specimens by Wang, Yiping, Fan, Joy Linyue, Melms, Johannes C., Amin, Amit Dipak, Georgis, Yohanna, Barrera, Irving, Ho, Patricia, Tagore, Somnath, Abril-Rodríguez, Gabriel, He, Siyu, Jin, Yinuo, Biermann, Jana, Hofree, Matan, Caprio, Lindsay, Berhe, Simon, Khan, Shaheer A., Henick, Brian S., Ribas, Antoni, Macosko, Evan Z., Chen, Fei, Taylor, Alison M., Schwartz, Gary K., Carvajal, Richard D., Azizi, Elham, Izar, Benjamin

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Abstract A021: Pre and post treatment transcriptomic analysis provide new insights on the mechanisms underlying the efficacy of PARPi and Androgen blockage in prostate cancer by Reis, Ana Filipa Palma dos, Milne-Clark, Toby, Amin, Amit Dipak, Nazlamova, Liliya, Pacey, Simon, Dev, Harveer

“…Abstract Aim: Recent phase 3 trials (PROPEL, TALAPRO2) have demonstrated survival benefits when combining PARP inhibitors (PARPi) with androgen pathway…”
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Induced Dependence On The ALK Kinase Inhibitor Crizotinib In Formerly Sensitive Anaplastic Large Cell Lymphoma Cells by Amit, Amin Dipak, Pongtornpipat, Praechompoo, Schatz, Jonathan H.

“…Kinase inhibitors can be highly effective against cancers driven by specific oncogenic kinase proteins, but resistance usually develops after prolonged…”
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The mechanism of cancer drug addiction in ALK-positive T-Cell lymphoma by Rajan, Soumya S., Amin, Amit Dipak, Li, Lingxiao, Rolland, Delphine C., Li, Haiquan, Kwon, Deukwoo, Kweh, Mercedes F., Arumov, Artavazd, Roberts, Evan R., Yan, Aimin, Basrur, Venkatesha, Elenitoba-Johnson, Kojo S. J., Chen, Xi Steven, Puvvada, Soham D., Lussier, Yves A., Bilbao, Daniel, Lim, Megan S., Schatz, Jonathan H.

“…Rational new strategies are needed to treat tumors resistant to kinase inhibitors. Mechanistic studies of resistance provide fertile ground for development of…”
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